Detailed information NTG1067358

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: ACHZEV_RS11595
• Genome accession: NZ_CP172401
• Coordinates: 2405193..2406236 (+)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain M22.2
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2400193..2411236

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ACHZEV_RS11565 (ACHZEV_11565)	-	2400808..2400918 (+)	111	WP_014937049.1	hypothetical protein	-
ACHZEV_RS11570 (ACHZEV_11570)	-	2400947..2401360 (+)	414	WP_025174370.1	hypothetical protein	-
ACHZEV_RS11575 (ACHZEV_11575)	-	2401549..2402535 (-)	987	WP_000999712.1	aromatic acid exporter family protein	-
ACHZEV_RS11580 (ACHZEV_11580)	map	2403119..2403877 (+)	759	WP_000636145.1	type I methionyl aminopeptidase	-
ACHZEV_RS11585 (ACHZEV_11585)	-	2404094..2404480 (+)	387	WP_001110182.1	hypothetical protein	-
ACHZEV_RS11590 (ACHZEV_11590)	liaF	2404495..2405196 (+)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
ACHZEV_RS11595 (ACHZEV_11595)	vraS	2405193..2406236 (+)	1044	WP_001017131.1	sensor histidine kinase	Regulator
ACHZEV_RS11600 (ACHZEV_11600)	vraR	2406226..2406855 (+)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
ACHZEV_RS11605 (ACHZEV_11605)	-	2406968..2408185 (-)	1218	WP_000037081.1	YihY/virulence factor BrkB family protein	-
ACHZEV_RS11610 (ACHZEV_11610)	-	2408463..2408738 (-)	276	WP_000428172.1	YtxH domain-containing protein	-
ACHZEV_RS11615 (ACHZEV_11615)	-	2408745..2409209 (-)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
ACHZEV_RS11620 (ACHZEV_11620)	-	2409356..2409556 (+)	201	WP_000180460.1	DUF1128 family protein	-
ACHZEV_RS11625 (ACHZEV_11625)	-	2409559..2410815 (+)	1257	WP_074347694.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=1067358 ACHZEV_RS11595 WP_001017131.1 2405193..2406236(+) (vraS) [Staphylococcus aureus strain M22.2]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=1067358 ACHZEV_RS11595 WP_001017131.1 2405193..2406236(+) (vraS) [Staphylococcus aureus strain M22.2]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTTCTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAATTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAATTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGCTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1