Detailed information    

insolico Bioinformatically predicted

Overview

Name   comM   Type   Regulator
Locus tag   AABA16_RS09025 Genome accession   NZ_AP028610
Coordinates   1748583..1749203 (-) Length   206 a.a.
NCBI ID   WP_000839908.1    Uniprot ID   A0A0B7M636
Organism   Streptococcus pneumoniae strain Sep5     
Function   fratricide immunity (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Genomic island 1737003..1760272 1748583..1749203 within 0


Gene organization within MGE regions


Location: 1737003..1760272
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  AABA16_RS08955 (TKY124516_17510) - 1737003..1737263 (-) 261 WP_001209196.1 hypothetical protein -
  AABA16_RS08960 (TKY124516_17520) - 1737322..1737873 (-) 552 WP_001111264.1 hypothetical protein -
  AABA16_RS08965 (TKY124516_17530) - 1737863..1738853 (-) 991 Protein_1753 hypothetical protein -
  AABA16_RS08970 (TKY124516_17550) - 1739261..1739686 (-) 426 WP_000204060.1 hypothetical protein -
  AABA16_RS08975 (TKY124516_17560) - 1739820..1740173 (-) 354 WP_001829107.1 hypothetical protein -
  AABA16_RS08980 (TKY124516_17570) - 1740219..1740425 (-) 207 WP_000366087.1 hypothetical protein -
  AABA16_RS08985 (TKY124516_17580) - 1740412..1740573 (-) 162 WP_000289348.1 helix-turn-helix transcriptional regulator -
  AABA16_RS08990 (TKY124516_17590) lytA 1740951..1741907 (-) 957 WP_000405240.1 N-acetylmuramoyl-L-alanine amidase LytA -
  AABA16_RS08995 (TKY124516_17600) - 1742283..1743653 (-) 1371 WP_001036285.1 MATE family efflux transporter -
  AABA16_RS09000 (TKY124516_17610) recA 1743960..1745126 (-) 1167 WP_001085462.1 recombinase RecA Machinery gene
  AABA16_RS09005 (TKY124516_17620) cinA 1745181..1746437 (-) 1257 WP_000642709.1 competence/damage-inducible protein A Machinery gene
  AABA16_RS09010 (TKY124516_17630) - 1746522..1747538 (-) 1017 WP_000239278.1 LCP family protein -
  AABA16_RS09015 (TKY124516_17640) - 1747546..1748064 (-) 519 WP_000455535.1 GNAT family N-acetyltransferase -
  AABA16_RS09020 (TKY124516_17650) tsaE 1748054..1748497 (-) 444 WP_000288232.1 tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex ATPase subunit type 1 TsaE -
  AABA16_RS09025 (TKY124516_17660) comM 1748583..1749203 (-) 621 WP_000839908.1 hypothetical protein Regulator
  AABA16_RS09030 (TKY124516_17670) - 1749586..1750449 (-) 864 WP_001093618.1 helix-turn-helix transcriptional regulator -
  AABA16_RS09035 (TKY124516_17680) - 1750641..1750811 (+) 171 WP_001227862.1 PhrA family quorum-sensing system peptide -
  AABA16_RS09040 (TKY124516_17690) pneA1 1750914..1751138 (+) 225 WP_000181086.1 two-peptide bacteriocin subunit PneA1 -
  AABA16_RS09045 (TKY124516_17700) pneA2 1751145..1751333 (+) 189 WP_000786759.1 two-peptide bacteriocin subunit PneA2 -
  AABA16_RS09050 (TKY124516_17710) lanM 1751450..1754440 (+) 2991 WP_000875571.1 type 2 lanthipeptide synthetase LanM -
  AABA16_RS09055 (TKY124516_17720) - 1754790..1755494 (+) 705 WP_001033170.1 flavodoxin family protein -
  AABA16_RS09060 (TKY124516_17730) - 1755475..1756404 (+) 930 WP_000912954.1 M50 family metallopeptidase -
  AABA16_RS09065 (TKY124516_17740) - 1756401..1758509 (+) 2109 WP_000701298.1 peptidase domain-containing ABC transporter -
  AABA16_RS09070 (TKY124516_17750) - 1758533..1760272 (+) 1740 WP_054381205.1 S8 family serine peptidase -

Sequence

Protein


Download         Length: 206 a.a.        Molecular weight: 23552.72 Da        Isoelectric Point: 10.1254

>NTDB_id=106532 AABA16_RS09025 WP_000839908.1 1748583..1749203(-) (comM) [Streptococcus pneumoniae strain Sep5]
MKSMRILFLLALIQISLSSCFLWKECILSFKQSTAFFIGSMVFVSGICAGVNYLYTRKQEVHSVLASKKSVKLFYSMLLL
INLLGAVLVLSDNLFIKNTLQQELVDFLLPSFFFLFGLDLLIFLPLKKYVRDFLAMLDRKKTVLVTILATLLFLRNPMTI
VSLLIYIGLGLFFAAYLVPNSVKKEVSFYGHIFRDLVLVIVTLIFF

Nucleotide


Download         Length: 621 bp        

>NTDB_id=106532 AABA16_RS09025 WP_000839908.1 1748583..1749203(-) (comM) [Streptococcus pneumoniae strain Sep5]
ATGAAATCAATGAGAATCTTATTTTTGTTAGCTTTAATTCAAATCAGTTTGAGTAGCTGTTTCCTATGGAAGGAATGCAT
CTTGTCCTTTAAACAAAGTACAGCTTTTTTCATCGGAAGCATGGTTTTCGTTTCAGGAATCTGTGCTGGAGTAAATTATC
TTTATACCCGTAAGCAAGAAGTCCATAGTGTCCTAGCCAGTAAGAAGTCGGTGAAGCTTTTTTACAGTATGTTACTCTTA
ATTAATTTGTTAGGAGCTGTTCTTGTTTTGTCAGATAACTTGTTCATCAAAAATACGCTGCAGCAAGAATTAGTTGACTT
TTTATTGCCATCCTTCTTTTTCCTATTTGGGCTAGATTTGCTGATTTTTTTACCCTTGAAAAAATACGTGCGCGATTTTC
TTGCTATGCTAGACAGAAAAAAGACAGTGTTGGTGACTATTTTAGCAACACTTCTTTTCTTAAGAAATCCAATGACCATT
GTCTCACTTCTGATTTATATTGGACTGGGCTTGTTTTTTGCAGCCTATCTTGTCCCAAATTCGGTTAAGAAGGAAGTTTC
CTTTTATGGTCATATTTTCCGAGATCTTGTATTGGTCATTGTTACGCTCATTTTCTTTTAG

Domains


No domain identified.



Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A0B7M636

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comM Streptococcus pneumoniae D39

100

100

1
  comM Streptococcus pneumoniae R6

100

100

1
  comM Streptococcus pneumoniae TIGR4

100

100

1
  comM Streptococcus mitis NCTC 12261

38.974

94.66

0.369
  comM Streptococcus mitis SK321

38.974

94.66

0.369

Multiple sequence alignment