Detailed information    

insolico Bioinformatically predicted

Overview

Name   clpC   Type   Regulator
Locus tag   AABA19_RS10630 Genome accession   NZ_AP028609
Coordinates   2072954..2075386 (-) Length   810 a.a.
NCBI ID   WP_050251270.1    Uniprot ID   -
Organism   Streptococcus pneumoniae strain Sep4     
Function   degradation of ComW (predicted from homology)   
Competence regulation

Genomic Context

Location: 2067954..2080386
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  AABA19_RS10610 (TKY121806_20550) pspC 2067981..2069951 (-) 1971 WP_338170914.1 pneumococcal surface protein PspC, choline-binding form -
  AABA19_RS10615 (TKY121806_20560) - 2070030..2070557 (-) 528 WP_000241929.1 isoprenylcysteine carboxyl methyltransferase family protein -
  AABA19_RS10620 (TKY121806_20570) hk06 2070652..2071983 (-) 1332 WP_000594663.1 two-component system sensor histidine kinase HK06 -
  AABA19_RS10625 (TKY121806_20580) rr06 2071980..2072633 (-) 654 WP_001024075.1 two-component system response regulator RR06 -
  AABA19_RS10630 (TKY121806_20590) clpC 2072954..2075386 (-) 2433 WP_050251270.1 ATP-dependent Clp protease ATP-binding subunit Regulator
  AABA19_RS10635 (TKY121806_20600) - 2075388..2075846 (-) 459 WP_001211279.1 CtsR family transcriptional regulator -
  AABA19_RS10640 (TKY121806_20610) - 2075965..2076693 (-) 729 WP_000136224.1 ABC transporter ATP-binding protein -
  AABA19_RS10645 (TKY121806_20620) - 2076693..2077700 (-) 1008 WP_000754546.1 ABC transporter substrate-binding protein -
  AABA19_RS10650 (TKY121806_20630) - 2077739..2078497 (-) 759 WP_001245129.1 ABC transporter permease -
  AABA19_RS10655 (TKY121806_20640) - 2078460..2078750 (-) 291 WP_000647661.1 thiamine-binding protein -
  AABA19_RS10660 (TKY121806_20650) cbpD 2079006..2080124 (-) 1119 WP_338170921.1 choline binding-anchored murein hydrolase CbpD -

Sequence

Protein


Download         Length: 810 a.a.        Molecular weight: 90199.97 Da        Isoelectric Point: 5.8610

>NTDB_id=106475 AABA19_RS10630 WP_050251270.1 2072954..2075386(-) (clpC) [Streptococcus pneumoniae strain Sep4]
MNYSKALNECIESAYMVAGHFGARYLESWHLLIAMSNHSYSVAGATLNDYPYEMDRLEEVALELTETDYSQDETFTELPF
SRRLQVLFDEAEYVASVVHAKVLGTEHVLYAILHDGNALATRILERAGFSYEDKKDQVKIAALRRNLEERAGWTREDLKA
LRQRHRTVADKQNSMANMMGMPQTPSGGLEDYTHDLTEQARSGKLEPVIGRDKEISRMIQILSRKTKNNPVLVGDAGVGK
TALALGLAQRIASGDVPAEMAKMRVLELDLMNVVAGTRFRGDFEERMNNIIKDIEEDGQVILFIDELHTIMGSGSGIDST
LDAANILKPALARGTLRTVGATTQEEYQKHIEKDAALSRRFAKVTIEEPSVADSMTILQGLKATYEKHHRVQITDEAVET
AVKMAHRYLTSRHLPDSAIDLLDEAAATVQNKAKHVKADDSDLSPADKALMDGKWKQAAQLIAKEEEVPVYKDLVTESDI
LTTLSRLSGIPVQKLTQTDAKKYLNLEAELHKRVIGQDQAVSSISRAIRRNQSGIRSHKRPIGSFMFLGPTGVGKTELAK
ALAEVLFDDESALIRFDMSEYMEKFAASRLNGAPPGYVGYEEGGELTEKVRNKPYSVLLFDEVEKAHPDIFNVLLQVLDD
GVLTDSKGRKVDFSNTIIIMTSNLGATALRDDKTVGFGAKDIRFDQENMEKRMFEELKKAYRPEFINRIDEKVVFHSLSS
DHMQEVVKIMVKPLVASLAEKCIDLKLQASALKLLANQGYDPEMGARPLRRTLQTEVEDKLAELLIKGDLVAGSTLKIGV
KAGQLKFDIA

Nucleotide


Download         Length: 2433 bp        

>NTDB_id=106475 AABA19_RS10630 WP_050251270.1 2072954..2075386(-) (clpC) [Streptococcus pneumoniae strain Sep4]
ATGAACTATTCAAAAGCATTGAATGAATGTATCGAAAGTGCCTACATGGTTGCTGGACATTTTGGAGCTCGTTATCTAGA
GTCTTGGCACTTGTTGATTGCCATGTCTAATCACAGTTATAGTGTAGCAGGGGCAACTTTAAATGATTATCCGTATGAGA
TGGACCGTTTAGAAGAGGTGGCTTTGGAACTGACTGAAACGGACTATAGCCAGGATGAAACCTTTACGGAATTGCCGTTC
TCCCGTCGTTTGCAGGTTCTTTTTGATGAAGCAGAGTATGTAGCGTCAGTGGTCCATGCTAAGGTACTAGGGACAGAGCA
CGTCCTCTATGCGATTTTGCATGATGGCAATGCCTTGGCGACTCGTATCTTGGAGAGGGCTGGTTTTTCTTATGAAGACA
AGAAAGATCAGGTCAAGATTGCTGCTCTTCGTCGAAATTTAGAAGAACGGGCAGGCTGGACTCGTGAAGATCTCAAGGCT
TTACGCCAACGCCATCGTACAGTAGCTGACAAGCAAAATTCTATGGCCAATATGATGGGCATGCCGCAGACTCCTAGTGG
TGGTCTCGAGGACTATACGCATGATTTGACAGAGCAAGCGCGTTCTGGCAAGTTAGAACCAGTCATCGGTCGGGACAAGG
AAATCTCACGTATGATTCAAATCTTGAGCCGTAAGACTAAGAACAACCCTGTCTTGGTTGGGGATGCTGGTGTCGGGAAA
ACAGCTCTGGCCCTTGGTCTTGCCCAGCGTATTGCTAGTGGTGACGTGCCTGCGGAAATGGCTAAGATGCGCGTGTTAGA
ACTTGATTTGATGAATGTCGTTGCAGGGACACGCTTCCGTGGTGACTTTGAAGAACGCATGAATAATATCATCAAGGATA
TTGAAGAAGATGGCCAAGTCATCCTCTTTATCGATGAACTCCACACCATCATGGGTTCTGGTAGCGGGATTGATTCGACT
CTGGATGCGGCCAATATCTTGAAACCAGCCTTGGCGCGTGGAACTTTGAGAACGGTTGGTGCCACCACTCAGGAAGAATA
TCAAAAACATATCGAAAAAGATGCGGCTCTTTCTCGTCGTTTCGCTAAAGTGACGATTGAAGAACCAAGTGTGGCAGATA
GTATGACTATTTTACAAGGTTTGAAGGCGACTTATGAGAAACATCACCGTGTACAAATCACAGATGAAGCGGTTGAAACA
GCGGTTAAGATGGCTCATCGTTATTTAACCAGTCGTCACTTGCCAGACTCTGCTATCGACCTCTTGGATGAGGCGGCAGC
AACAGTGCAAAATAAGGCAAAGCATGTAAAAGCAGACGATTCAGATTTGAGTCCAGCTGACAAGGCCCTGATGGATGGCA
AGTGGAAACAGGCAGCCCAGCTAATCGCAAAAGAAGAGGAAGTGCCTGTCTACAAAGACTTGGTGACAGAGTCTGATATT
TTGACCACCTTGAGTCGCTTGTCAGGAATCCCAGTTCAAAAACTGACTCAAACGGATGCTAAGAAGTATTTAAATCTTGA
AGCAGAACTCCATAAACGGGTTATCGGTCAAGATCAAGCTGTTTCAAGTATTAGTCGTGCGATTCGCCGTAATCAGTCAG
GAATTCGCAGTCACAAGCGTCCGATCGGTTCCTTTATGTTCCTAGGACCCACAGGTGTCGGTAAGACCGAGTTGGCCAAG
GCTTTGGCAGAAGTTCTCTTTGATGACGAATCAGCCCTTATCCGCTTTGATATGAGTGAGTATATGGAGAAATTCGCAGC
CAGCCGTCTAAATGGAGCTCCTCCAGGCTATGTGGGTTACGAAGAAGGTGGGGAGTTGACAGAGAAGGTTCGCAATAAAC
CCTATTCCGTTCTCCTCTTTGATGAGGTAGAGAAGGCTCACCCAGATATCTTTAATGTTCTCTTGCAGGTTCTGGATGAC
GGTGTCTTGACAGATAGCAAGGGACGCAAGGTCGATTTTTCAAATACCATTATCATTATGACATCGAACCTAGGTGCGAC
TGCTCTTCGTGATGATAAGACTGTTGGTTTTGGGGCTAAGGATATTCGTTTTGACCAGGAAAATATGGAAAAACGCATGT
TTGAAGAACTGAAAAAAGCTTATAGACCGGAATTCATCAACCGTATTGATGAGAAGGTGGTCTTCCATAGCCTATCTAGT
GACCATATGCAGGAAGTGGTGAAGATTATGGTCAAGCCTTTAGTTGCAAGTTTGGCTGAAAAATGCATTGACTTGAAATT
ACAAGCTTCAGCTCTGAAATTGTTAGCAAATCAAGGATATGACCCAGAGATGGGAGCTCGCCCACTTCGCAGAACCCTGC
AAACAGAAGTGGAGGACAAGTTGGCAGAACTTCTTATCAAGGGAGATTTAGTGGCAGGCAGCACACTTAAGATTGGTGTC
AAAGCAGGCCAGTTAAAATTTGATATTGCATAA

Domains

Predicted by InterproScan.

AAA lid domain (AAA_lid_9)

(370-444)

Clp amino terminal domain, pathogenicity island component (Clp_N)

(103-139)

AAA domain (Cdc48 subfamily) (AAA_2)

(540-711)

C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small)

(718-797)

ATPase family associated with various cellular activities (AAA) (AAA)

(231-362)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  clpC Streptococcus pneumoniae D39

99.506

100

0.995
  clpC Streptococcus pneumoniae TIGR4

99.506

100

0.995
  clpC Streptococcus pneumoniae Rx1

99.506

100

0.995
  clpC Streptococcus mutans UA159

66.667

100

0.669
  clpC Streptococcus thermophilus LMD-9

65.971

100

0.663
  clpC Streptococcus thermophilus LMG 18311

65.848

100

0.662
  clpC Lactococcus lactis subsp. lactis strain DGCC12653

48.678

100

0.5
  clpC Bacillus subtilis subsp. subtilis str. 168

45.117

99.877

0.451
  clpE Streptococcus mutans UA159

49.194

76.543

0.377
  clpE Streptococcus pneumoniae Rx1

47.134

77.531

0.365
  clpE Streptococcus pneumoniae D39

47.134

77.531

0.365
  clpE Streptococcus pneumoniae R6

47.134

77.531

0.365
  clpE Streptococcus pneumoniae TIGR4

47.134

77.531

0.365
  clpC Lactococcus lactis subsp. cremoris KW2

47.115

77.037

0.363

Multiple sequence alignment