Detailed information NTG1057373

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: ACFIOS_RS09255
• Genome accession: NZ_CP170436
• Coordinates: 1905267..1906310 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain t1510
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1900267..1911310

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ACFIOS_RS09225	-	1900689..1901936 (-)	1248	WP_000656302.1	aminopeptidase	-
ACFIOS_RS09230	-	1901948..1902148 (-)	201	WP_000180459.1	DUF1128 family protein	-
ACFIOS_RS09235	-	1902295..1902759 (+)	465	WP_000228668.1	low molecular weight protein-tyrosine-phosphatase	-
ACFIOS_RS09240	-	1902766..1903041 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
ACFIOS_RS09245	-	1903319..1904535 (+)	1217	Protein_1780	YihY/virulence factor BrkB family protein	-
ACFIOS_RS09250	vraR	1904648..1905277 (-)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
ACFIOS_RS09255	vraS	1905267..1906310 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
ACFIOS_RS09260	liaF	1906307..1907008 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
ACFIOS_RS09265	-	1907023..1907409 (-)	387	WP_001110184.1	hypothetical protein	-
ACFIOS_RS09270	map	1907626..1908384 (-)	759	WP_000636137.1	type I methionyl aminopeptidase	-
ACFIOS_RS09275	-	1908915..1909901 (+)	987	WP_000999713.1	FUSC family protein	-
ACFIOS_RS09280	-	1910079..1910492 (-)	414	WP_001622129.1	hypothetical protein	-
ACFIOS_RS09285	-	1910521..1910630 (-)	110	Protein_1788	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=1057373 ACFIOS_RS09255 WP_001017131.1 1905267..1906310(-) (vraS) [Staphylococcus aureus strain t1510]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=1057373 ACFIOS_RS09255 WP_001017131.1 1905267..1906310(-) (vraS) [Staphylococcus aureus strain t1510]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTACCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTCGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1