Detailed information NTG1057220

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: ACFIOD_RS04350
• Genome accession: NZ_CP170429
• Coordinates: 838810..839853 (+)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain t1531
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 833810..844853

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ACFIOD_RS04320	-	834236..834346 (+)	111	WP_001790257.1	hypothetical protein	-
ACFIOD_RS04325	-	834375..834788 (+)	414	WP_001557448.1	hypothetical protein	-
ACFIOD_RS04330	-	835219..836205 (-)	987	WP_000999717.1	FUSC family protein	-
ACFIOD_RS04335	map	836736..837494 (+)	759	WP_000636142.1	type I methionyl aminopeptidase	-
ACFIOD_RS04340	-	837711..838097 (+)	387	WP_001110179.1	hypothetical protein	-
ACFIOD_RS04345	liaF	838112..838813 (+)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
ACFIOD_RS04350	vraS	838810..839853 (+)	1044	WP_001017131.1	sensor histidine kinase	Regulator
ACFIOD_RS04355	vraR	839843..840472 (+)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
ACFIOD_RS04360	-	840585..841802 (-)	1218	WP_000037075.1	YihY/virulence factor BrkB family protein	-
ACFIOD_RS04365	-	842080..842355 (-)	276	WP_000428172.1	YtxH domain-containing protein	-
ACFIOD_RS04370	-	842362..842826 (-)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
ACFIOD_RS04375	-	842973..843173 (+)	201	WP_000180460.1	DUF1128 family protein	-
ACFIOD_RS04380	-	843176..844432 (+)	1257	WP_001795108.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=1057220 ACFIOD_RS04350 WP_001017131.1 838810..839853(+) (vraS) [Staphylococcus aureus strain t1531]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=1057220 ACFIOD_RS04350 WP_001017131.1 838810..839853(+) (vraS) [Staphylococcus aureus strain t1531]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTATTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCATACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCTCGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTTTCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1