Detailed information NTG1057005

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: ACFIOL_RS04280
• Genome accession: NZ_CP170416
• Coordinates: 845437..846480 (+)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain t21644
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 840437..851480

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ACFIOL_RS04250	-	840803..840914 (+)	112	Protein_835	hypothetical protein	-
ACFIOL_RS04255	-	840943..841356 (+)	414	WP_001837236.1	hypothetical protein	-
ACFIOL_RS04260	-	841846..842832 (-)	987	WP_000999713.1	FUSC family protein	-
ACFIOL_RS04265	map	843363..844121 (+)	759	WP_000636142.1	type I methionyl aminopeptidase	-
ACFIOL_RS04270	-	844338..844724 (+)	387	WP_001110179.1	hypothetical protein	-
ACFIOL_RS04275	liaF	844739..845440 (+)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
ACFIOL_RS04280	vraS	845437..846480 (+)	1044	WP_001017131.1	sensor histidine kinase	Regulator
ACFIOL_RS04285	vraR	846470..847099 (+)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
ACFIOL_RS04290	-	847211..848422 (-)	1212	WP_000037091.1	YihY/virulence factor BrkB family protein	-
ACFIOL_RS04295	-	848700..848975 (-)	276	WP_000428172.1	YtxH domain-containing protein	-
ACFIOL_RS04300	-	848982..849446 (-)	465	WP_278198359.1	low molecular weight phosphotyrosine protein phosphatase	-
ACFIOL_RS04305	-	849593..849793 (+)	201	WP_000180460.1	DUF1128 family protein	-
ACFIOL_RS04310	-	849796..851052 (+)	1257	WP_001793428.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=1057005 ACFIOL_RS04280 WP_001017131.1 845437..846480(+) (vraS) [Staphylococcus aureus strain t21644]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=1057005 ACFIOL_RS04280 WP_001017131.1 845437..846480(+) (vraS) [Staphylococcus aureus strain t21644]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTATTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCATACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAATTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCTCGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTTTCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCGATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1