Detailed information NTG1056949

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: ACFIOE_RS09395
• Genome accession: NZ_CP170411
• Coordinates: 1919830..1920873 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain t002
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1914830..1925873

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ACFIOE_RS09365	-	1915251..1916507 (-)	1257	WP_001795108.1	aminopeptidase	-
ACFIOE_RS09370	-	1916510..1916710 (-)	201	WP_000180460.1	DUF1128 family protein	-
ACFIOE_RS09375	-	1916857..1917321 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
ACFIOE_RS09380	-	1917328..1917603 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
ACFIOE_RS09385	-	1917881..1919098 (+)	1218	WP_000037075.1	YihY/virulence factor BrkB family protein	-
ACFIOE_RS09390	vraR	1919211..1919840 (-)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
ACFIOE_RS09395	vraS	1919830..1920873 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
ACFIOE_RS09400	liaF	1920870..1921571 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
ACFIOE_RS09405	-	1921586..1921972 (-)	387	WP_001110179.1	hypothetical protein	-
ACFIOE_RS09410	map	1922189..1922947 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
ACFIOE_RS09415	-	1923478..1924464 (+)	987	WP_000999717.1	FUSC family protein	-
ACFIOE_RS09420	-	1924895..1925308 (-)	414	WP_001557448.1	hypothetical protein	-
ACFIOE_RS09425	-	1925337..1925447 (-)	111	WP_001790257.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=1056949 ACFIOE_RS09395 WP_001017131.1 1919830..1920873(-) (vraS) [Staphylococcus aureus strain t002]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=1056949 ACFIOE_RS09395 WP_001017131.1 1919830..1920873(-) (vraS) [Staphylococcus aureus strain t002]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTATTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCATACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCTCGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTTTCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1