Detailed information NTG1056714

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: ACFION_RS04285
• Genome accession: NZ_CP170399
• Coordinates: 844757..845800 (+)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain t127
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 839757..850800

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ACFION_RS04255	-	840182..840293 (+)	112	Protein_836	hypothetical protein	-
ACFION_RS04260	-	840322..840735 (+)	414	WP_001837236.1	hypothetical protein	-
ACFION_RS04265	-	841166..842152 (-)	987	WP_000999713.1	FUSC family protein	-
ACFION_RS04270	map	842683..843441 (+)	759	WP_000636142.1	type I methionyl aminopeptidase	-
ACFION_RS04275	-	843658..844044 (+)	387	WP_001110179.1	hypothetical protein	-
ACFION_RS04280	liaF	844059..844760 (+)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
ACFION_RS04285	vraS	844757..845800 (+)	1044	WP_001017131.1	sensor histidine kinase	Regulator
ACFION_RS04290	vraR	845790..846419 (+)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
ACFION_RS04295	-	846531..847742 (-)	1212	WP_000037091.1	YihY/virulence factor BrkB family protein	-
ACFION_RS04300	-	848020..848295 (-)	276	WP_000428172.1	YtxH domain-containing protein	-
ACFION_RS04305	-	848302..848766 (-)	465	WP_278198359.1	low molecular weight phosphotyrosine protein phosphatase	-
ACFION_RS04310	-	848913..849113 (+)	201	WP_000180460.1	DUF1128 family protein	-
ACFION_RS04315	-	849116..850372 (+)	1257	WP_001793428.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=1056714 ACFION_RS04285 WP_001017131.1 844757..845800(+) (vraS) [Staphylococcus aureus strain t127]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=1056714 ACFION_RS04285 WP_001017131.1 844757..845800(+) (vraS) [Staphylococcus aureus strain t127]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTATTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCATACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAATTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCTCGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTTTCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCGATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1