Detailed information NTG1056590

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: ACFIOJ_RS04255
• Genome accession: NZ_CP170391
• Coordinates: 832370..833413 (+)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain t21642
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 827370..838413

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ACFIOJ_RS04225	-	827661..827771 (+)	111	WP_001790257.1	hypothetical protein	-
ACFIOJ_RS04230	-	827800..828213 (+)	414	WP_410534037.1	hypothetical protein	-
ACFIOJ_RS04235	-	828666..829652 (-)	987	WP_410533695.1	FUSC family protein	-
ACFIOJ_RS04240	map	830296..831054 (+)	759	WP_000636142.1	type I methionyl aminopeptidase	-
ACFIOJ_RS04245	-	831271..831657 (+)	387	WP_001110179.1	hypothetical protein	-
ACFIOJ_RS04250	liaF	831672..832373 (+)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
ACFIOJ_RS04255	vraS	832370..833413 (+)	1044	WP_001017131.1	sensor histidine kinase	Regulator
ACFIOJ_RS04260	vraR	833403..834032 (+)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
ACFIOJ_RS04265	-	834142..835359 (-)	1218	WP_000037088.1	YihY/virulence factor BrkB family protein	-
ACFIOJ_RS04270	-	835637..835912 (-)	276	WP_000428172.1	YtxH domain-containing protein	-
ACFIOJ_RS04275	-	835919..836383 (-)	465	WP_054189636.1	low molecular weight protein-tyrosine-phosphatase	-
ACFIOJ_RS04280	-	836530..836730 (+)	201	WP_000180460.1	DUF1128 family protein	-
ACFIOJ_RS04285	-	836733..837989 (+)	1257	WP_077446664.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=1056590 ACFIOJ_RS04255 WP_001017131.1 832370..833413(+) (vraS) [Staphylococcus aureus strain t21642]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=1056590 ACFIOJ_RS04255 WP_001017131.1 832370..833413(+) (vraS) [Staphylococcus aureus strain t21642]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACGGTTGGTATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAACGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACAAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTCCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCACTTGGTTTAAAAG
ACAAATCATTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1