Detailed information NTG1054113

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: U2B25_RS10305
• Genome accession: NZ_CP169947
• Coordinates: 2070962..2072005 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain BSN57-2
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2065962..2077005

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
U2B25_RS10275 (U2B25_10275)	-	2066383..2067639 (-)	1257	WP_001795108.1	aminopeptidase	-
U2B25_RS10280 (U2B25_10280)	-	2067642..2067842 (-)	201	WP_000180460.1	DUF1128 family protein	-
U2B25_RS10285 (U2B25_10285)	-	2067989..2068453 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
U2B25_RS10290 (U2B25_10290)	-	2068460..2068735 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
U2B25_RS10295 (U2B25_10295)	-	2069013..2070230 (+)	1218	WP_000037075.1	YihY/virulence factor BrkB family protein	-
U2B25_RS10300 (U2B25_10300)	vraR	2070343..2070972 (-)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
U2B25_RS10305 (U2B25_10305)	vraS	2070962..2072005 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
U2B25_RS10310 (U2B25_10310)	liaF	2072002..2072703 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
U2B25_RS10315 (U2B25_10315)	-	2072718..2073104 (-)	387	WP_001110179.1	hypothetical protein	-
U2B25_RS10320 (U2B25_10320)	map	2073321..2074079 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
U2B25_RS10325 (U2B25_10325)	-	2074610..2075596 (+)	987	WP_000999717.1	FUSC family protein	-
U2B25_RS10330 (U2B25_10330)	-	2076027..2076440 (-)	414	WP_001557448.1	hypothetical protein	-
U2B25_RS10335 (U2B25_10335)	-	2076469..2076579 (-)	111	WP_001790257.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=1054113 U2B25_RS10305 WP_001017131.1 2070962..2072005(-) (vraS) [Staphylococcus aureus strain BSN57-2]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=1054113 U2B25_RS10305 WP_001017131.1 2070962..2072005(-) (vraS) [Staphylococcus aureus strain BSN57-2]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTATTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCATACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCTCGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTTTCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1