Detailed information NTG1052208

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: ACE2AN_RS09035
• Genome accession: NZ_CP169564
• Coordinates: 1788061..1789098 (-)
• Length: 345 a.a.
• NCBI ID: WP_000727277.1
• Uniprot ID: A0A0B7LHQ0
• Organism: Streptococcus pneumoniae strain 6_2F1
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 1783061..1794098

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ACE2AN_RS09010	-	1783800..1785131 (-)	1332	WP_000390039.1	hemolysin family protein	-
ACE2AN_RS09015	endA	1785422..1786246 (-)	825	WP_050199562.1	DNA-entry nuclease EndA	Machinery gene
ACE2AN_RS09020	-	1786285..1786473 (-)	189	WP_001036519.1	DNA-directed RNA polymerase subunit beta	-
ACE2AN_RS09025	murA	1786466..1787749 (-)	1284	WP_000358028.1	UDP-N-acetylglucosamine 1-carboxyvinyltransferase	-
ACE2AN_RS09030	-	1787773..1788003 (-)	231	WP_000250393.1	DUF1146 family protein	-
ACE2AN_RS09035	sepM	1788061..1789098 (-)	1038	WP_000727277.1	SepM family pheromone-processing serine protease	Regulator
ACE2AN_RS09040	coaD	1789082..1789570 (-)	489	WP_375060530.1	pantetheine-phosphate adenylyltransferase	-
ACE2AN_RS09045	rsmD	1789560..1790099 (-)	540	WP_000706963.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
ACE2AN_RS09050	asnA	1790164..1791156 (-)	993	WP_000747993.1	aspartate--ammonia ligase	-
ACE2AN_RS09055	-	1791268..1791951 (-)	684	WP_001016913.1	Bax inhibitor-1/YccA family protein	-
ACE2AN_RS09060	-	1792007..1792747 (-)	741	WP_000152693.1	RNA methyltransferase	-
ACE2AN_RS09065	-	1792781..1793059 (+)	279	WP_001174613.1	acylphosphatase	-
ACE2AN_RS09070	yidC	1793137..1794063 (+)	927	WP_000835942.1	membrane protein insertase YidC	-

Sequence

Protein

• Length: 345 a.a.
• Molecular weight: 37537.57 Da
• Isoelectric Point: 5.0724

>NTDB_id=1052208 ACE2AN_RS09035 WP_000727277.1 1788061..1789098(-) (sepM) [Streptococcus pneumoniae strain 6_2F1]
MKKKIRWPLYVIAALIVTFLAFVVPLPYYIEVPGGSEDIRQVLKVNDTEDKEAGAYQFVTVGVQHATLAHMIYAWLTPFT
DIRSAQETTGGSSDVEFMRINQFYMQTSQNMAKYQGLKTAGKDIELKYFGVYVLNVTDNSTFKGILNISDTVTAVNDQTF
DSSKDLIDYVSSQKLGDSVKVTYEEDGQTKSAEGKIITLENGKNGIGIGLIDRTEVISNVPISFSTAGIGGPSAGLMFSL
AIYTQIAHPDLRNGRIVAGTGTIDRDGNVGDIGGIDKKVVASARAGAAIFFAPDNPVSEEEQKAHPDAKNNYQTALEAAK
TIKTDMKIVPVKTLQDAIDYLKNNP

Nucleotide

• Length: 1038 bp

>NTDB_id=1052208 ACE2AN_RS09035 WP_000727277.1 1788061..1789098(-) (sepM) [Streptococcus pneumoniae strain 6_2F1]
ATGAAAAAAAAGATTAGATGGCCCTTATACGTCATTGCGGCCTTGATTGTGACTTTCTTGGCATTTGTAGTGCCCTTGCC
TTATTATATAGAGGTTCCAGGTGGTTCGGAAGATATTCGCCAAGTCCTTAAAGTAAATGACACAGAAGATAAGGAAGCTG
GTGCCTATCAATTCGTTACGGTTGGTGTTCAACATGCTACTTTAGCTCATATGATTTATGCTTGGTTGACACCTTTTACA
GATATTCGTAGTGCTCAGGAGACTACAGGTGGTTCTTCCGATGTTGAATTTATGCGAATCAATCAATTCTACATGCAAAC
ATCACAAAATATGGCCAAGTATCAAGGTCTAAAAACAGCTGGTAAGGATATCGAACTCAAGTACTTTGGGGTTTATGTCT
TGAATGTGACGGATAATTCAACCTTTAAAGGGATTCTCAATATCTCTGATACGGTCACAGCAGTCAATGATCAGACCTTT
GATAGTTCCAAAGACTTGATTGATTACGTCAGTTCTCAAAAATTAGGGGACTCCGTCAAGGTCACCTATGAAGAGGATGG
GCAAACCAAGTCTGCAGAAGGAAAGATTATCACCTTGGAAAATGGAAAAAATGGGATTGGAATCGGCTTGATTGATCGTA
CAGAGGTAATCAGCAATGTCCCAATTAGCTTTTCAACAGCTGGTATTGGCGGCCCAAGTGCTGGTCTCATGTTTAGTCTA
GCTATCTATACTCAAATAGCTCACCCAGATCTTCGTAATGGTCGTATTGTTGCCGGTACAGGTACCATTGACCGCGATGG
TAATGTGGGAGACATTGGAGGTATTGATAAGAAGGTTGTAGCTTCGGCTAGGGCAGGTGCTGCTATTTTCTTTGCTCCTG
ATAACCCTGTTAGCGAAGAAGAACAAAAGGCGCATCCGGACGCGAAAAACAACTACCAAACAGCCCTAGAAGCGGCTAAA
ACAATCAAGACGGATATGAAAATCGTGCCCGTTAAAACCCTACAAGATGCGATTGATTACTTGAAAAACAATCCCTAA

Domains

Predicted by InterproScan.

• PDZ domain (PDZ_2) (130-193)

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (230-296)

3D structure

• AlphaFold DB: A0A0B7LHQ0

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	59.649	99.13	0.591