Detailed information NTG1050235

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: ACEY2J_RS00470
• Genome accession: NZ_CP169293
• Coordinates: 82561..83604 (+)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain NSA 739
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 77561..88604

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ACEY2J_RS00440 (ACEY2J_00440)	-	77872..77982 (+)	111	WP_001790257.1	hypothetical protein	-
ACEY2J_RS00445 (ACEY2J_00445)	-	78011..78424 (+)	414	WP_001549145.1	hypothetical protein	-
ACEY2J_RS00450 (ACEY2J_00450)	-	78914..79900 (-)	987	WP_000999713.1	aromatic acid exporter family protein	-
ACEY2J_RS00455 (ACEY2J_00455)	map	80487..81245 (+)	759	WP_000636142.1	type I methionyl aminopeptidase	-
ACEY2J_RS00460 (ACEY2J_00460)	-	81462..81848 (+)	387	WP_001110179.1	hypothetical protein	-
ACEY2J_RS00465 (ACEY2J_00465)	liaF	81863..82564 (+)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
ACEY2J_RS00470 (ACEY2J_00470)	vraS	82561..83604 (+)	1044	WP_001017131.1	sensor histidine kinase	Regulator
ACEY2J_RS00475 (ACEY2J_00475)	vraR	83594..84223 (+)	630	WP_000153530.1	two-component system response regulator VraR	Regulator
ACEY2J_RS00480 (ACEY2J_00480)	-	84339..85556 (-)	1218	WP_000037075.1	YihY/virulence factor BrkB family protein	-
ACEY2J_RS00485 (ACEY2J_00485)	-	85834..86109 (-)	276	WP_000428172.1	YtxH domain-containing protein	-
ACEY2J_RS00490 (ACEY2J_00490)	-	86116..86580 (-)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
ACEY2J_RS00495 (ACEY2J_00495)	-	86727..86927 (+)	201	WP_000180461.1	DUF1128 family protein	-
ACEY2J_RS00500 (ACEY2J_00500)	-	86930..88186 (+)	1257	WP_001795438.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=1050235 ACEY2J_RS00470 WP_001017131.1 82561..83604(+) (vraS) [Staphylococcus aureus strain NSA 739]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=1050235 ACEY2J_RS00470 WP_001017131.1 82561..83604(+) (vraS) [Staphylococcus aureus strain NSA 739]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTTTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
TATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1