Detailed information NTG1050070

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: ACEWY3_RS04605
• Genome accession: NZ_CP169265
• Coordinates: 921347..922390 (+)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain CBC226
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 916347..927390

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ACEWY3_RS04575 (ACEWY3_04575)	-	916717..916827 (+)	111	WP_001790257.1	hypothetical protein	-
ACEWY3_RS04580 (ACEWY3_04580)	-	916856..917269 (+)	414	WP_001549145.1	hypothetical protein	-
ACEWY3_RS04585 (ACEWY3_04585)	-	917700..918686 (-)	987	WP_374150827.1	FUSC family protein	-
ACEWY3_RS04590 (ACEWY3_04590)	map	919273..920031 (+)	759	WP_000636142.1	type I methionyl aminopeptidase	-
ACEWY3_RS04595 (ACEWY3_04595)	-	920248..920634 (+)	387	WP_001110179.1	hypothetical protein	-
ACEWY3_RS04600 (ACEWY3_04600)	liaF	920649..921350 (+)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
ACEWY3_RS04605 (ACEWY3_04605)	vraS	921347..922390 (+)	1044	WP_001017131.1	sensor histidine kinase	Regulator
ACEWY3_RS04610 (ACEWY3_04610)	vraR	922380..923009 (+)	630	WP_000153530.1	two-component system response regulator VraR	Regulator
ACEWY3_RS04615 (ACEWY3_04615)	-	923125..924342 (-)	1218	WP_000037075.1	YihY/virulence factor BrkB family protein	-
ACEWY3_RS04620 (ACEWY3_04620)	-	924620..924895 (-)	276	WP_000428172.1	YtxH domain-containing protein	-
ACEWY3_RS04625 (ACEWY3_04625)	-	924902..925366 (-)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
ACEWY3_RS04630 (ACEWY3_04630)	-	925513..925713 (+)	201	WP_000180461.1	DUF1128 family protein	-
ACEWY3_RS04635 (ACEWY3_04635)	-	925716..926972 (+)	1257	WP_001795438.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=1050070 ACEWY3_RS04605 WP_001017131.1 921347..922390(+) (vraS) [Staphylococcus aureus strain CBC226]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=1050070 ACEWY3_RS04605 WP_001017131.1 921347..922390(+) (vraS) [Staphylococcus aureus strain CBC226]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTTTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
TATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1