Detailed information NTG1049107

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: ACCK32_RS10475
• Genome accession: NZ_CP168975
• Coordinates: 2089073..2090116 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain CUBIST-8
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2084073..2095116

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ACCK32_RS10445 (ACCK32_10445)	-	2084491..2085747 (-)	1257	WP_001795438.1	aminopeptidase	-
ACCK32_RS10450 (ACCK32_10450)	-	2085750..2085950 (-)	201	WP_000180461.1	DUF1128 family protein	-
ACCK32_RS10455 (ACCK32_10455)	-	2086097..2086561 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
ACCK32_RS10460 (ACCK32_10460)	-	2086568..2086843 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
ACCK32_RS10465 (ACCK32_10465)	-	2087121..2088338 (+)	1218	WP_000037075.1	YihY/virulence factor BrkB family protein	-
ACCK32_RS10470 (ACCK32_10470)	vraR	2088454..2089083 (-)	630	WP_000153530.1	two-component system response regulator VraR	Regulator
ACCK32_RS10475 (ACCK32_10475)	vraS	2089073..2090116 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
ACCK32_RS10480 (ACCK32_10480)	liaF	2090113..2090814 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
ACCK32_RS10485 (ACCK32_10485)	-	2090829..2091215 (-)	387	WP_001110179.1	hypothetical protein	-
ACCK32_RS10490 (ACCK32_10490)	map	2091432..2092190 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
ACCK32_RS10495 (ACCK32_10495)	-	2092718..2093704 (+)	987	WP_000999713.1	aromatic acid exporter family protein	-
ACCK32_RS10500 (ACCK32_10500)	-	2094077..2094490 (-)	414	WP_001549145.1	hypothetical protein	-
ACCK32_RS10505 (ACCK32_10505)	-	2094519..2094629 (-)	111	WP_001790257.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=1049107 ACCK32_RS10475 WP_001017131.1 2089073..2090116(-) (vraS) [Staphylococcus aureus strain CUBIST-8]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=1049107 ACCK32_RS10475 WP_001017131.1 2089073..2090116(-) (vraS) [Staphylococcus aureus strain CUBIST-8]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTTTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
TATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1