Detailed information    

insolico Bioinformatically predicted

Overview

Name   clpE   Type   Regulator
Locus tag   U8955_RS01820 Genome accession   NZ_OY769914
Coordinates   328323..330428 (+) Length   701 a.a.
NCBI ID   WP_038804145.1    Uniprot ID   -
Organism   Streptococcus oralis subsp. dentisani isolate Streptococcus dentisani 7746     
Function   repress competence development (at the early growth phase) (predicted from homology)   
Competence regulation

Genomic Context

Location: 323323..335428
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  U8955_RS01805 (SDENT7746_01835) - 323437..324282 (+) 846 WP_038804148.1 undecaprenyl-diphosphate phosphatase -
  U8955_RS01810 (SDENT7746_01840) dinB 324316..325377 (-) 1062 WP_038804147.1 DNA polymerase IV -
  U8955_RS01815 (SDENT7746_01845) pflB 325614..327929 (+) 2316 WP_038804146.1 formate C-acetyltransferase -
  U8955_RS01820 (SDENT7746_01850) clpE 328323..330428 (+) 2106 WP_038804145.1 ATP-dependent Clp protease ATP-binding subunit Regulator
  U8955_RS01825 (SDENT7746_01855) - 330486..330968 (-) 483 WP_000032544.1 S-ribosylhomocysteine lyase -
  U8955_RS01830 (SDENT7746_01860) - 331254..331961 (+) 708 WP_038804144.1 ABC transporter ATP-binding protein -
  U8955_RS01835 (SDENT7746_01865) - 331963..332751 (+) 789 WP_038804143.1 lantibiotic ABC transporter permease -
  U8955_RS01840 (SDENT7746_01870) - 332751..333473 (+) 723 WP_038804142.1 lantibiotic ABC transporter permease -
  U8955_RS01845 (SDENT7746_01875) - 333486..334184 (+) 699 WP_038804141.1 response regulator transcription factor -
  U8955_RS01850 (SDENT7746_01880) - 334151..335182 (+) 1032 WP_038804140.1 sensor histidine kinase -

Sequence

Protein


Download         Length: 701 a.a.        Molecular weight: 77534.33 Da        Isoelectric Point: 4.7655

>NTDB_id=1047482 U8955_RS01820 WP_038804145.1 328323..330428(+) (clpE) [Streptococcus oralis subsp. dentisani isolate Streptococcus dentisani 7746]
MNNNFNNFNNMDDLFNQLMGGMRGYSSENRRYLINGREVTPEEFAHYRATGQLPGNAESDAQMQQHASGMKQDGVLAKLG
RNLTAEAREGKLDPVIGRNKEIQETSEILSRRTKNNPVLVGDAGVGKTAVVEGLAQAIVNGDVPAAIKNKEIISIDISGL
EAGTQYRGSFEENIQNLVSEVKEAGNIILFFDEIHQILGAGSTGGDSGSKGLADILKPALSRGELTVIGATTQDEYRNTI
LKNAALARRFNEVKVNAPSAEDTFKILQGIRDLYQQHHNVILPDEVLKAAVDYSIQYIPQRSLPDKAIDLVDVTAAHLAA
QHPVTDVHAVEREIEAEKDKQEKAVEAEDFEAALNAKTRIAELEKKVENHTEDMKVTASINDVAESVERMTGIPVSQMGA
SDIERLKDMAHRLEHKVIGQDKAVEAVARAIRRNRAGFDEGNRPIGSFLFVGPTGVGKTELAKQLALDMFGTKDAIIRLD
MSEYSDRTAVSKLIGTTAGYVGYDDNSNTLTERVRRNPYSIILLDEIEKADPQVITLLLQVLDDGRLTDGQGNTVNFKNT
VIIATSNAGFGYEVNLTEDADKPELMDRLKPFFRPEFLNRFNAVIEFSHLNKEDLSKIVDLMLAEVNQTLAKKDIDLEVS
QVAKDFITEEGYDEVMGVRPLRRVVEQQIRDKVTDFHLDNLDAKHLEADMENGVLVIREKA

Nucleotide


Download         Length: 2106 bp        

>NTDB_id=1047482 U8955_RS01820 WP_038804145.1 328323..330428(+) (clpE) [Streptococcus oralis subsp. dentisani isolate Streptococcus dentisani 7746]
ATGAATAACAACTTTAATAACTTTAACAACATGGATGATTTGTTTAACCAATTGATGGGTGGTATGCGAGGATACAGTTC
TGAAAACCGTCGCTACTTGATTAATGGACGTGAAGTGACTCCTGAGGAATTTGCTCATTATCGTGCAACTGGTCAATTAC
CAGGAAATGCAGAATCTGATGCGCAAATGCAACAACACGCTTCAGGTATGAAGCAAGATGGTGTCCTTGCTAAACTAGGT
CGTAACTTGACAGCAGAAGCTCGCGAGGGCAAATTGGATCCTGTTATCGGACGAAACAAGGAAATTCAAGAAACATCTGA
AATCCTATCCCGTCGTACCAAGAACAATCCTGTACTTGTAGGAGATGCAGGTGTTGGTAAGACAGCAGTTGTCGAAGGTT
TAGCACAAGCAATTGTGAACGGAGATGTCCCAGCTGCTATTAAGAACAAGGAAATCATTTCCATTGATATCTCAGGTCTT
GAGGCTGGTACTCAATACCGTGGTAGTTTTGAAGAAAACATTCAAAATCTTGTTAGTGAGGTAAAAGAAGCAGGGAATAT
TATCCTCTTCTTTGATGAAATTCACCAAATTCTTGGTGCTGGTAGCACTGGTGGAGACAGTGGCTCCAAGGGGCTTGCGG
ACATTCTCAAGCCAGCTCTCTCTCGTGGTGAGTTGACTGTTATTGGGGCAACGACTCAAGACGAATACCGTAACACCATC
TTGAAGAATGCAGCTCTTGCTCGTCGTTTCAACGAAGTCAAGGTCAATGCTCCATCAGCAGAGGATACCTTTAAAATCCT
TCAAGGGATTCGTGACCTCTATCAACAACATCACAATGTTATCTTGCCAGACGAAGTCTTGAAGGCAGCAGTGGATTATT
CTATCCAATACATTCCACAACGCAGCTTGCCAGATAAGGCTATCGACCTTGTCGATGTAACGGCAGCTCACTTGGCAGCT
CAACATCCTGTAACAGATGTTCATGCTGTTGAACGAGAAATCGAGGCAGAAAAAGACAAGCAAGAAAAAGCTGTTGAGGC
AGAAGATTTTGAAGCAGCTCTTAATGCCAAGACACGCATTGCAGAATTGGAGAAAAAAGTCGAAAACCACACAGAAGACA
TGAAAGTGACTGCAAGCATCAACGATGTGGCTGAATCTGTGGAACGAATGACAGGTATTCCAGTGTCACAAATGGGAGCG
TCAGACATCGAACGTTTGAAAGATATGGCTCATCGTTTGGAACACAAGGTAATCGGCCAAGACAAGGCAGTTGAAGCTGT
AGCTCGTGCTATCCGTCGTAACCGTGCTGGTTTTGATGAAGGCAATCGCCCAATCGGTAGCTTCCTCTTTGTAGGTCCAA
CTGGGGTTGGTAAGACAGAACTTGCTAAGCAATTAGCGCTCGATATGTTTGGAACGAAGGATGCGATTATCCGTTTGGAT
ATGTCTGAATACAGTGACCGCACAGCCGTATCTAAGCTAATTGGTACAACAGCTGGTTATGTTGGGTATGATGACAATAG
CAATACCTTGACAGAACGTGTTCGTCGCAATCCATACTCTATCATTCTCTTGGATGAAATTGAAAAGGCTGATCCTCAAG
TAATCACCCTTCTCCTCCAAGTCTTGGATGACGGTCGTTTGACTGATGGTCAAGGAAATACAGTGAACTTCAAGAACACG
GTCATTATCGCAACATCAAATGCTGGATTTGGCTATGAAGTCAACTTGACAGAAGATGCTGACAAACCAGAATTGATGGA
TCGTTTGAAACCATTCTTCCGCCCAGAGTTCCTTAACCGCTTTAACGCAGTTATCGAGTTCTCACACTTGAATAAGGAAG
ACCTTTCTAAGATTGTGGACTTGATGTTGGCGGAAGTCAACCAAACCTTGGCTAAGAAAGACATTGATTTGGAAGTCAGC
CAAGTAGCTAAGGACTTTATCACAGAAGAAGGTTATGACGAAGTCATGGGTGTTCGTCCACTCCGCCGTGTGGTTGAACA
ACAAATTCGTGATAAGGTGACAGACTTCCACTTGGATAACCTTGATGCTAAACACCTAGAAGCAGATATGGAAAATGGTG
TCTTGGTCATTCGTGAAAAAGCCTAA

Domains

Predicted by InterProScan.

AAA lid domain (AAA_lid_9)

(259-354)

C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small)

(610-680)

ATPase family associated with various cellular activities (AAA) (AAA)

(118-250)

AAA domain (Cdc48 subfamily) (AAA_2)

(443-603)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  clpE Streptococcus mutans UA159

50.466

91.869

0.464
  clpC Lactococcus lactis subsp. cremoris KW2

49.531

91.298

0.452
  clpE Streptococcus pneumoniae Rx1

48.661

90.585

0.441
  clpE Streptococcus pneumoniae D39

48.661

90.585

0.441
  clpE Streptococcus pneumoniae R6

48.661

90.585

0.441
  clpE Streptococcus pneumoniae TIGR4

48.58

90.442

0.439
  clpC Bacillus subtilis subsp. subtilis str. 168

45.146

92.582

0.418
  clpC Streptococcus pneumoniae Rx1

43.109

89.016

0.384
  clpC Streptococcus pneumoniae D39

43.109

89.016

0.384
  clpC Streptococcus pneumoniae TIGR4

42.949

89.016

0.382
  clpC Streptococcus thermophilus LMD-9

42.95

88.017

0.378
  clpC Lactococcus lactis subsp. lactis strain DGCC12653

42.788

88.017

0.377
  clpC Streptococcus thermophilus LMG 18311

42.788

88.017

0.377
  clpC Streptococcus mutans UA159

42.071

88.16

0.371

Multiple sequence alignment