Detailed information NTG1045536

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: D712_RS09750
• Genome accession: NZ_CP168754
• Coordinates: 1985731..1986774 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain D712
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1980731..1991774

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
D712_RS09720 (D712_009720)	-	1981152..1982408 (-)	1257	WP_001795108.1	aminopeptidase	-
D712_RS09725 (D712_009725)	-	1982411..1982611 (-)	201	WP_000180460.1	DUF1128 family protein	-
D712_RS09730 (D712_009730)	-	1982758..1983222 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
D712_RS09735 (D712_009735)	-	1983229..1983504 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
D712_RS09740 (D712_009740)	-	1983782..1984999 (+)	1218	WP_000037075.1	YihY/virulence factor BrkB family protein	-
D712_RS09745 (D712_009745)	vraR	1985112..1985741 (-)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
D712_RS09750 (D712_009750)	vraS	1985731..1986774 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
D712_RS09755 (D712_009755)	liaF	1986771..1987472 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
D712_RS09760 (D712_009760)	-	1987487..1987873 (-)	387	WP_001110179.1	hypothetical protein	-
D712_RS09765 (D712_009765)	map	1988090..1988848 (-)	759	WP_000636140.1	type I methionyl aminopeptidase	-
D712_RS09770 (D712_009770)	-	1989379..1990365 (+)	987	WP_000999717.1	aromatic acid exporter family protein	-
D712_RS09775 (D712_009775)	-	1990796..1991209 (-)	414	WP_001557448.1	hypothetical protein	-
D712_RS09780 (D712_009780)	-	1991238..1991348 (-)	111	WP_001790257.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=1045536 D712_RS09750 WP_001017131.1 1985731..1986774(-) (vraS) [Staphylococcus aureus strain D712]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=1045536 D712_RS09750 WP_001017131.1 1985731..1986774(-) (vraS) [Staphylococcus aureus strain D712]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTATTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCATACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCTCGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTTTCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1