Detailed information    

insolico Bioinformatically predicted

Overview

Name   braS   Type   Regulator
Locus tag   ACCK26_RS13795 Genome accession   NZ_CP168160
Coordinates   2743286..2744173 (-) Length   295 a.a.
NCBI ID   WP_000143425.1    Uniprot ID   A0A389PV50
Organism   Staphylococcus aureus strain CUBIST-33     
Function   promote expression of competence genes (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
ICE 2685285..2744010 2743286..2744173 flank -724


Gene organization within MGE regions


Location: 2685285..2744173
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ACCK26_RS13485 (ACCK26_13485) - 2685335..2685631 (-) 297 WP_000447709.1 DUF4176 domain-containing protein -
  ACCK26_RS13490 (ACCK26_13490) - 2685619..2685987 (-) 369 WP_000066369.1 hypothetical protein -
  ACCK26_RS13495 (ACCK26_13495) - 2686002..2686280 (-) 279 WP_020977619.1 TIGR04197 family type VII secretion effector -
  ACCK26_RS13500 (ACCK26_13500) - 2686621..2687487 (-) 867 WP_001005523.1 fructosamine kinase family protein -
  ACCK26_RS13505 (ACCK26_13505) - 2687705..2688769 (+) 1065 WP_000277419.1 quinone-dependent dihydroorotate dehydrogenase -
  ACCK26_RS13510 (ACCK26_13510) - 2688924..2689199 (+) 276 WP_000159839.1 hypothetical protein -
  ACCK26_RS13515 (ACCK26_13515) - 2689385..2690107 (-) 723 WP_000606210.1 epoxyqueuosine reductase QueH -
  ACCK26_RS13520 (ACCK26_13520) - 2690461..2690910 (+) 450 WP_000125705.1 VOC family protein -
  ACCK26_RS13525 (ACCK26_13525) - 2690991..2691578 (-) 588 WP_000151110.1 TetR/AcrR family transcriptional regulator -
  ACCK26_RS13530 (ACCK26_13530) - 2691556..2691664 (-) 109 Protein_2623 hypothetical protein -
  ACCK26_RS13535 (ACCK26_13535) - 2691721..2693403 (+) 1683 WP_001071595.1 CocE/NonD family hydrolase -
  ACCK26_RS13540 (ACCK26_13540) sasK 2693501..2694136 (-) 636 WP_000755982.1 LPXTG-anchored surface protein SasK -
  ACCK26_RS13545 (ACCK26_13545) - 2694152..2695228 (-) 1077 WP_000161220.1 serine protease -
  ACCK26_RS13550 (ACCK26_13550) panD 2695571..2695954 (-) 384 WP_000621532.1 aspartate 1-decarboxylase -
  ACCK26_RS13555 (ACCK26_13555) panC 2695956..2696807 (-) 852 WP_000163737.1 pantoate--beta-alanine ligase -
  ACCK26_RS13560 (ACCK26_13560) panB 2696800..2697618 (-) 819 WP_000860047.1 3-methyl-2-oxobutanoate hydroxymethyltransferase -
  ACCK26_RS13565 (ACCK26_13565) - 2697691..2698551 (+) 861 WP_000953572.1 oxidoreductase -
  ACCK26_RS13570 (ACCK26_13570) budA 2698637..2699341 (-) 705 WP_000186117.1 acetolactate decarboxylase -
  ACCK26_RS13575 (ACCK26_13575) - 2699619..2700578 (-) 960 WP_000846636.1 L-lactate dehydrogenase -
  ACCK26_RS13580 (ACCK26_13580) - 2701264..2702712 (+) 1449 WP_000534425.1 APC family permease -
  ACCK26_RS13585 (ACCK26_13585) - 2702793..2704130 (-) 1338 WP_031763561.1 aspartate aminotransferase family protein -
  ACCK26_RS13590 (ACCK26_13590) - 2704388..2704804 (+) 417 WP_001237629.1 hypothetical protein -
  ACCK26_RS13595 (ACCK26_13595) - 2704927..2705817 (+) 891 WP_001031409.1 fructose bisphosphate aldolase -
  ACCK26_RS13600 (ACCK26_13600) lqo 2706011..2707507 (-) 1497 WP_001130051.1 L-lactate dehydrogenase (quinone) -
  ACCK26_RS13605 (ACCK26_13605) - 2707803..2708132 (+) 330 WP_001791980.1 hypothetical protein -
  ACCK26_RS13610 (ACCK26_13610) mbcS 2708192..2709790 (-) 1599 WP_001581849.1 acyl-CoA synthetase MbcS -
  ACCK26_RS13615 (ACCK26_13615) - 2709984..2710427 (-) 444 WP_001028775.1 antibiotic biosynthesis monooxygenase -
  ACCK26_RS13620 (ACCK26_13620) - 2710707..2710919 (-) 213 WP_000011688.1 sterile alpha motif-like domain-containing protein -
  ACCK26_RS13625 (ACCK26_13625) betA 2711197..2712906 (-) 1710 WP_000066521.1 choline dehydrogenase -
  ACCK26_RS13630 (ACCK26_13630) betB 2713167..2714657 (-) 1491 WP_000421713.1 betaine-aldehyde dehydrogenase -
  ACCK26_RS13635 (ACCK26_13635) - 2714726..2714821 (+) 96 WP_001789908.1 hypothetical protein -
  ACCK26_RS13640 (ACCK26_13640) - 2714910..2715473 (+) 564 WP_000198598.1 GbsR/MarR family transcriptional regulator -
  ACCK26_RS13645 (ACCK26_13645) - 2715644..2717266 (-) 1623 WP_000711870.1 BCCT family transporter -
  ACCK26_RS13650 (ACCK26_13650) - 2717398..2717559 (+) 162 WP_001791976.1 hypothetical protein -
  ACCK26_RS13655 (ACCK26_13655) - 2717575..2717685 (-) 111 WP_001791975.1 hypothetical protein -
  ACCK26_RS13660 (ACCK26_13660) nrdG 2717785..2718321 (-) 537 WP_000173331.1 anaerobic ribonucleoside-triphosphate reductase activating protein -
  ACCK26_RS13665 (ACCK26_13665) nrdD 2718318..2720168 (-) 1851 WP_001071729.1 anaerobic ribonucleoside-triphosphate reductase -
  ACCK26_RS13670 (ACCK26_13670) - 2720358..2721728 (-) 1371 WP_234771115.1 citrate:proton symporter -
  ACCK26_RS13675 (ACCK26_13675) - 2722050..2722145 (-) 96 WP_001789304.1 hypothetical protein -
  ACCK26_RS13680 (ACCK26_13680) - 2722221..2722826 (-) 606 WP_001057052.1 NAD(P)-binding protein -
  ACCK26_RS13685 (ACCK26_13685) - 2722889..2724769 (-) 1881 WP_000775150.1 assimilatory sulfite reductase (NADPH) flavoprotein subunit -
  ACCK26_RS13690 (ACCK26_13690) - 2724963..2725055 (+) 93 WP_010956583.1 hypothetical protein -
  ACCK26_RS13695 (ACCK26_13695) - 2725163..2725660 (-) 498 WP_001065268.1 glutathione peroxidase -
  ACCK26_RS13700 (ACCK26_13700) - 2725670..2725930 (-) 261 WP_001791974.1 hypothetical protein -
  ACCK26_RS13705 (ACCK26_13705) - 2726312..2726425 (-) 114 Protein_2658 hypothetical protein -
  ACCK26_RS13710 (ACCK26_13710) - 2727247..2727783 (-) 537 WP_078056058.1 IS30 family transposase -
  ACCK26_RS13715 (ACCK26_13715) - 2727764..2728267 (-) 504 WP_000746372.1 transposase -
  ACCK26_RS13720 (ACCK26_13720) - 2728376..2728717 (-) 342 WP_001255377.1 cystatin-like fold lipoprotein -
  ACCK26_RS13725 (ACCK26_13725) - 2728773..2729363 (-) 591 WP_000810443.1 hypothetical protein -
  ACCK26_RS13730 (ACCK26_13730) - 2729370..2730416 (-) 1047 WP_000247474.1 CHAP domain-containing protein -
  ACCK26_RS13735 (ACCK26_13735) - 2730406..2732253 (-) 1848 WP_000681147.1 CD3337/EF1877 family mobilome membrane protein -
  ACCK26_RS13740 (ACCK26_13740) - 2732258..2733616 (-) 1359 WP_001251200.1 FtsK/SpoIIIE domain-containing protein -
  ACCK26_RS13745 (ACCK26_13745) - 2733670..2736165 (-) 2496 WP_373334206.1 ATP-binding protein -
  ACCK26_RS13750 (ACCK26_13750) - 2736200..2736583 (-) 384 WP_000358144.1 TcpE family conjugal transfer membrane protein -
  ACCK26_RS13755 (ACCK26_13755) - 2736595..2736855 (-) 261 WP_000015644.1 TcpD family membrane protein -
  ACCK26_RS13760 (ACCK26_13760) - 2736860..2737915 (-) 1056 WP_000692005.1 conjugal transfer protein -
  ACCK26_RS13765 (ACCK26_13765) - 2737976..2739067 (-) 1092 WP_000172934.1 replication initiation factor domain-containing protein -
  ACCK26_RS13770 (ACCK26_13770) - 2739242..2739544 (-) 303 WP_000386891.1 hypothetical protein -
  ACCK26_RS13775 (ACCK26_13775) - 2739558..2739878 (-) 321 WP_000805733.1 DUF961 family protein -
  ACCK26_RS13780 (ACCK26_13780) - 2740029..2740313 (-) 285 WP_000134550.1 hypothetical protein -
  ACCK26_RS13785 (ACCK26_13785) - 2740426..2742426 (-) 2001 WP_000776751.1 ABC transporter permease -
  ACCK26_RS13790 (ACCK26_13790) - 2742423..2743178 (-) 756 WP_000923760.1 ABC transporter ATP-binding protein -
  ACCK26_RS13795 (ACCK26_13795) braS 2743286..2744173 (-) 888 WP_000143425.1 nisin susceptibility-associated two-component system sensor histidine kinase NsaS Regulator

Sequence

Protein


Download         Length: 295 a.a.        Molecular weight: 34006.28 Da        Isoelectric Point: 6.0874

>NTDB_id=1042851 ACCK26_RS13795 WP_000143425.1 2743286..2744173(-) (braS) [Staphylococcus aureus strain CUBIST-33]
MTFLKSITQEIAIVIVIFALFGLMFYLYHLPLEAYLLALGVILLLLLIFIGIKYLSFVKTISQQQQIENLETALYQLKNE
QIEYKNDVESYFLTWVHQMKTPITAAQLLLERDEPNVVNRVRQEVIQIDNYTSLALSYLKLLNETSDISVTKISINNIIR
PIIMKYSIQFIDQKTKIHYEPCHHEVLTDVRWTSLMIEQLINNALKYARGKDIWIEFDEQSNQLHVKDNGIGISEADLPK
IFDKGYSGYNGQRQSNSSGIGLFIVKQISTHTNHPVSVVSKQNEGTTFTIQFPDE

Nucleotide


Download         Length: 888 bp        

>NTDB_id=1042851 ACCK26_RS13795 WP_000143425.1 2743286..2744173(-) (braS) [Staphylococcus aureus strain CUBIST-33]
ATGACCTTTCTTAAAAGTATTACTCAGGAAATAGCAATAGTCATAGTTATTTTTGCTTTATTTGGCTTAATGTTTTACCT
GTATCATTTGCCATTAGAAGCATATTTACTAGCACTTGGCGTTATTTTATTATTATTACTCATATTCATAGGTATTAAAT
ATTTAAGTTTTGTAAAAACTATAAGCCAACAACAACAAATTGAAAACTTAGAAACTGCGTTGTATCAGCTTAAAAATGAA
CAAATTGAATATAAAAATGATGTAGAGAGCTACTTTTTAACATGGGTACATCAAATGAAAACACCCATTACTGCAGCACA
ACTGTTACTTGAAAGAGATGAGCCTAATGTTGTTAATCGTGTTCGTCAAGAGGTTATTCAAATTGATAACTATACAAGTT
TAGCACTTAGTTATTTAAAGTTATTAAATGAAACTTCTGATATTTCTGTCACTAAAATTTCGATTAATAATATCATTCGC
CCAATTATTATGAAATATTCAATACAGTTTATTGATCAAAAAACAAAAATCCATTATGAACCTTGTCATCACGAAGTATT
AACTGACGTTAGATGGACCTCTTTAATGATAGAACAATTAATAAATAATGCACTTAAGTATGCGAGAGGTAAAGATATAT
GGATTGAATTTGATGAGCAATCCAATCAATTACACGTAAAAGATAATGGTATCGGTATTAGTGAAGCGGACTTGCCTAAA
ATATTTGATAAGGGCTATTCAGGTTATAATGGCCAGCGCCAAAGTAACTCAAGTGGGATTGGTTTATTTATCGTAAAACA
AATTTCAACACACACAAACCATCCTGTTTCAGTCGTATCTAAACAAAATGAGGGTACAACATTTACGATTCAATTTCCAG
ATGAATAA

Domains

Predicted by InterproScan.

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c)

(191-294)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A389PV50

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  braS Staphylococcus aureus N315

100

100

1

Multiple sequence alignment