Detailed information NTG1042715

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: ACCK24_RS10320
• Genome accession: NZ_CP168154
• Coordinates: 2072227..2073270 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain CUBIST-6
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2067227..2078270

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ACCK24_RS10290 (ACCK24_10290)	-	2067648..2068904 (-)	1257	WP_001795108.1	aminopeptidase	-
ACCK24_RS10295 (ACCK24_10295)	-	2068907..2069107 (-)	201	WP_000180460.1	DUF1128 family protein	-
ACCK24_RS10300 (ACCK24_10300)	-	2069254..2069718 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
ACCK24_RS10305 (ACCK24_10305)	-	2069725..2070000 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
ACCK24_RS10310 (ACCK24_10310)	-	2070278..2071495 (+)	1218	WP_000037075.1	YihY/virulence factor BrkB family protein	-
ACCK24_RS10315 (ACCK24_10315)	vraR	2071608..2072237 (-)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
ACCK24_RS10320 (ACCK24_10320)	vraS	2072227..2073270 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
ACCK24_RS10325 (ACCK24_10325)	liaF	2073267..2073968 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
ACCK24_RS10330 (ACCK24_10330)	-	2073983..2074369 (-)	387	WP_001110179.1	hypothetical protein	-
ACCK24_RS10335 (ACCK24_10335)	map	2074586..2075344 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
ACCK24_RS10340 (ACCK24_10340)	-	2075874..2076860 (+)	987	WP_000999717.1	aromatic acid exporter family protein	-
ACCK24_RS10345 (ACCK24_10345)	-	2077291..2077704 (-)	414	WP_001557448.1	hypothetical protein	-
ACCK24_RS10350 (ACCK24_10350)	-	2077733..2077843 (-)	111	WP_001790257.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=1042715 ACCK24_RS10320 WP_001017131.1 2072227..2073270(-) (vraS) [Staphylococcus aureus strain CUBIST-6]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=1042715 ACCK24_RS10320 WP_001017131.1 2072227..2073270(-) (vraS) [Staphylococcus aureus strain CUBIST-6]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTATTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCATACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCTCGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTTTCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1