Detailed information NTG1042150

Bioinformatically predicted

Overview

• Name: agrA
• Type: Regulator
• Locus tag: ACCK25_RS10225
• Genome accession: NZ_CP168096
• Coordinates: 2059336..2060052 (+)
• Length: 238 a.a.
• NCBI ID: WP_000688492.1
• Uniprot ID: A0A7U7IEW1
• Organism: Staphylococcus aureus strain CUBIST-51
• Function: promote expression of competence genes (predicted from homology) Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type	MGE coordinates	Gene coordinates	Relative position	Distance (bp)
IS/Tn	2057667..2058986	2059336..2060052	flank	350

Gene organization within MGE regions

Location: 2057667..2060052

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ACCK25_RS10215 (ACCK25_10215)	-	2057667..2058986 (+)	1320	WP_001557163.1	ISL3-like element IS1181 family transposase	-
ACCK25_RS10220 (ACCK25_10220)	-	2059057..2059317 (+)	261	Protein_1945	GHKL domain-containing protein	-
ACCK25_RS10225 (ACCK25_10225)	agrA	2059336..2060052 (+)	717	WP_000688492.1	quorum-sensing response regulator AgrA	Regulator

Sequence

Protein

• Length: 238 a.a.
• Molecular weight: 27905.90 Da
• Isoelectric Point: 6.0927

>NTDB_id=1042150 ACCK25_RS10225 WP_000688492.1 2059336..2060052(+) (agrA) [Staphylococcus aureus strain CUBIST-51]
MKIFICEDDPKQRENMVTIIKNYIMIEEKPMEIALATDNPYEVLEQAKNMNDIGCYFLDIQLSTDINGIKLGSEIRKHDP
VGNIIFVTSHSELTYLTFVYKVAAMDFIFKDDPAELRTRIIDCLETAHTRLQLLSKDNSVETIELKRGSNSVYVQYDDIM
FFESSTKSHRLIAHLDNRQIEFYGNLKELSQLDDRFFRCHNSFVVNRHNIESIDSKERIVYFKNKEHCYASVRNVKKI

Nucleotide

• Length: 717 bp

>NTDB_id=1042150 ACCK25_RS10225 WP_000688492.1 2059336..2060052(+) (agrA) [Staphylococcus aureus strain CUBIST-51]
ATGAAAATTTTCATTTGCGAAGACGATCCAAAACAAAGAGAAAACATGGTTACCATTATTAAAAATTATATAATGATAGA
AGAAAAGCCTATGGAAATTGCCCTCGCAACTGATAATCCTTATGAGGTGCTTGAGCAAGCTAAAAATATGAATGACATAG
GCTGTTACTTTTTAGATATTCAACTTTCAACTGATATTAATGGTATCAAATTAGGCAGTGAAATTCGTAAGCATGACCCA
GTTGGTAACATTATTTTCGTTACGAGTCACAGTGAACTTACCTATTTAACATTTGTCTACAAAGTTGCAGCGATGGATTT
TATTTTTAAAGATGATCCAGCAGAATTAAGAACTCGAATTATAGATTGTTTAGAAACTGCACATACACGCTTACAATTGT
TGTCTAAAGATAATAGCGTTGAAACGATTGAATTAAAACGTGGCAGTAATTCAGTGTATGTTCAATATGATGATATTATG
TTTTTTGAATCATCAACAAAATCTCACAGACTCATTGCCCATTTAGATAACCGTCAAATTGAATTTTATGGTAATTTAAA
AGAACTGAGTCAATTAGATGATCGTTTCTTTAGATGTCATAATAGCTTTGTCGTCAATCGCCATAATATTGAATCTATAG
ATTCGAAAGAGCGAATTGTCTATTTTAAAAATAAAGAACACTGCTATGCATCGGTGAGAAACGTTAAAAAAATATAA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (3-120)

• LytTr DNA-binding domain (LytTR) (151-237)

3D structure

• AlphaFold DB: A0A7U7IEW1

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
agrA	Staphylococcus aureus N315	100	100	1