Detailed information NTG1042117

Bioinformatically predicted

Overview

• Name: ccrA
• Type: Machinery gene
• Locus tag: ACCK25_RS00415
• Genome accession: NZ_CP168096
• Coordinates: 58659..60008 (-)
• Length: 449 a.a.
• NCBI ID: WP_000815646.1
• Uniprot ID: Q9XB96
• Organism: Staphylococcus aureus strain CUBIST-51
• Function: promote SCCmec transfer (predicted from homology) Homologous recombination

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type	MGE coordinates	Gene coordinates	Relative position	Distance (bp)
SCCmec	38668..60008	58659..60008	within	0

Gene organization within MGE regions

Location: 38668..60008

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ACCK25_RS00310 (ACCK25_00310)	mecA	38668..40677 (-)	2010	WP_001801873.1	PBP2a family beta-lactam-resistant peptidoglycan transpeptidase MecA	-
ACCK25_RS00315 (ACCK25_00315)	mecR1	40774..42531 (+)	1758	WP_000952923.1	beta-lactam sensor/signal transducer MecR1	-
ACCK25_RS00320 (ACCK25_00320)	mecI	42531..42902 (+)	372	WP_000369214.1	mecA-type methicillin resistance repressor MecI	-
ACCK25_RS00325 (ACCK25_00325)	psm-mec	42987..43055 (-)	69	WP_014532405.1	phenol-soluble modulin PSM-mec	-
ACCK25_RS00330 (ACCK25_00330)	-	43389..44519 (+)	1131	WP_010922808.1	ROK family transcriptional regulator	-
ACCK25_RS00335 (ACCK25_00335)	cstB	44633..45967 (-)	1335	Protein_34	persulfide dioxygenase-sulfurtransferase CstB	-
ACCK25_RS00340 (ACCK25_00340)	-	46000..47064 (-)	1065	WP_000438836.1	DsrE/DsrF/DrsH-like family protein	-
ACCK25_RS00345 (ACCK25_00345)	cstR	47200..47460 (+)	261	WP_000220507.1	persulfide-sensing transcriptional repressor CstR	-
ACCK25_RS00350 (ACCK25_00350)	-	47460..48098 (+)	639	Protein_37	sulfite exporter TauE/SafE family protein	-
ACCK25_RS00355 (ACCK25_00355)	-	48443..49105 (-)	663	WP_001092058.1	class I SAM-dependent methyltransferase	-
ACCK25_RS00360 (ACCK25_00360)	-	49497..49556 (+)	60	WP_010959190.1	erythromycin resistance leader peptide	-
ACCK25_RS00365 (ACCK25_00365)	erm(A)	49614..50345 (+)	732	WP_001072201.1	23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(A)	-
ACCK25_RS00370 (ACCK25_00370)	-	50471..51253 (-)	783	WP_000067268.1	aminoglycoside nucleotidyltransferase ANT(9)-Ia	-
ACCK25_RS00375 (ACCK25_00375)	-	51404..51781 (-)	378	WP_000361059.1	DUF6262 family protein	-
ACCK25_RS00380 (ACCK25_00380)	-	51788..53680 (-)	1893	WP_001557544.1	site-specific integrase	-
ACCK25_RS00385 (ACCK25_00385)	-	53677..54762 (-)	1086	WP_000868132.1	tyrosine-type recombinase/integrase	-
ACCK25_RS00390 (ACCK25_00390)	-	54881..55198 (-)	318	WP_000659050.1	JAB domain-containing protein	-
ACCK25_RS00395 (ACCK25_00395)	-	55219..55725 (-)	507	WP_347323094.1	DUF1643 domain-containing protein	-
ACCK25_RS00400 (ACCK25_00400)	-	55743..56054 (-)	312	WP_000700853.1	DUF960 family protein	-
ACCK25_RS00405 (ACCK25_00405)	-	56141..56491 (-)	351	WP_000859155.1	SAUGI family uracil-DNA glycosylase inhibitor	-
ACCK25_RS00410 (ACCK25_00410)	ccrB	57009..58637 (-)	1629	WP_001186602.1	cassette chromosome recombinase CcrB	Machinery gene
ACCK25_RS00415 (ACCK25_00415)	ccrA	58659..60008 (-)	1350	WP_000815646.1	cassette chromosome recombinase CcrA	Machinery gene

Sequence

Protein

• Length: 449 a.a.
• Molecular weight: 52607.20 Da
• Isoelectric Point: 9.9585

>NTDB_id=1042117 ACCK25_RS00415 WP_000815646.1 58659..60008(-) (ccrA) [Staphylococcus aureus strain CUBIST-51]
MKQVIGYLRQSTMKQQSLAAQKQAIEAIAEKHHIQHINFYSDKQSGRKDNRSGYRQMTQLIQQGQCDILCCYRLNRLHRN
LKNALKLIKLCQTYHVHILSVHDGYFDMDQAFDRFKLNIFISLAELESDNIGEQVRNGLQEKAKQGRLITTHAPFGYEYH
NGAFIINQNESPTVKAVFNYYIKGHGYKKIAQLLEEDNTYINRQPYQVRNIIINPNYCGRVNNQYGQFDNMFPSIVSTSI
YEQAQRLRSQKQIKQTSSDNQLKQKIKCPCCNTTLTNMTVRKKNHTLRYYVCPKNMNASRFVCDFKGINAQTLEDKVLEV
CKDFYQNQRIYTKIKGAIDKRIKRQRNIEKHHTLTQEQLIEKLAQGIIDAETFREQTQSLRQQPQRTTSINGHQIQHTIQ
NIIQKRFTLNILYPYIETIHITKDKNLIGIYFKNEPLNIVNQTMQSSIA

Nucleotide

• Length: 1350 bp

>NTDB_id=1042117 ACCK25_RS00415 WP_000815646.1 58659..60008(-) (ccrA) [Staphylococcus aureus strain CUBIST-51]
ATGAAACAAGTCATAGGCTATTTACGTCAAAGTACGATGAAACAACAATCTCTTGCAGCACAGAAACAGGCTATCGAAGC
AATAGCCGAAAAACATCATATTCAACATATCAACTTTTATAGCGACAAACAATCAGGACGCAAAGATAATCGTAGTGGGT
ATCGACAAATGACGCAATTAATTCAACAAGGGCAATGTGACATATTATGTTGTTATCGTCTTAATAGATTACATCGTAAT
CTGAAAAATGCATTAAAACTCATCAAATTATGTCAAACATACCATGTTCATATCTTAAGCGTACACGATGGTTACTTTGA
TATGGATCAAGCTTTCGACCGATTCAAGCTTAATATTTTTATCAGCTTGGCCGAACTTGAATCAGATAACATTGGAGAAC
AAGTCAGAAATGGGCTTCAAGAAAAAGCAAAGCAAGGTCGATTGATTACAACCCATGCGCCCTTTGGTTACGAATATCAC
AACGGAGCATTCATCATCAATCAAAATGAGTCACCAACGGTAAAGGCTGTATTCAATTATTACATTAAAGGTCATGGTTA
TAAGAAAATTGCACAGTTATTAGAAGAAGATAACACGTATATCAATCGACAACCCTATCAAGTTCGTAACATTATCATCA
ATCCTAATTATTGTGGTCGTGTCAACAATCAATATGGCCAATTCGACAATATGTTTCCTTCTATTGTTTCCACAAGTATA
TATGAGCAAGCGCAGAGACTTCGATCGCAAAAACAAATCAAACAGACATCTTCGGATAACCAACTAAAACAAAAAATCAA
ATGCCCATGTTGTAATACAACACTTACGAATATGACCGTTAGAAAAAAGAATCATACATTACGTTACTACGTCTGTCCTA
AAAACATGAATGCTTCTCGCTTTGTCTGTGATTTTAAAGGCATCAATGCACAAACACTTGAAGATAAAGTATTAGAAGTG
TGCAAAGACTTTTATCAAAATCAACGCATCTACACAAAAATTAAAGGTGCGATTGACAAACGCATCAAAAGACAAAGAAA
CATAGAAAAACATCACACATTGACTCAAGAACAACTGATAGAAAAGTTGGCACAAGGCATCATCGATGCAGAAACGTTCA
GAGAACAAACGCAATCATTACGTCAACAACCGCAACGCACTACATCTATCAATGGACATCAAATACAACACACCATTCAA
AATATTATTCAAAAACGTTTCACGTTAAACATATTGTACCCCTATATTGAAACCATTCACATTACGAAAGATAAAAATCT
TATAGGAATCTATTTCAAAAATGAACCACTCAATATCGTCAATCAAACCATGCAATCATCGATTGCATAA

Domains

Predicted by InterproScan.

• Recombinase (Recombinase) (169-250)

• Recombinase zinc beta ribbon domain (Zn_ribbon_recom) (262-322)

• Resolvase, N terminal domain (Resolvase) (4-147)

3D structure

• AlphaFold DB: Q9XB96

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
ccrA	Staphylococcus aureus N315	100	100	1
ccrA	Staphylococcus aureus COL	74.833	100	0.748