Detailed information
Bioinformatically predicted
Overview
| Name | ccrA | Type | Machinery gene |
| Locus tag | ACCK19_RS00225 | Genome accession | NZ_CP168091 |
| Coordinates | 52425..53774 (-) | Length | 449 a.a. |
| NCBI ID | WP_000815638.1 | Uniprot ID | Q53IL8 |
| Organism | Staphylococcus aureus strain CUBIST-16 | ||
| Function | promote SCCmec transfer (predicted from homology) Homologous recombination |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| ICE | 27508..83341 | 52425..53774 | within | 0 |
| SCCmec | 44011..61171 | 52425..53774 | within | 0 |
Gene organization within MGE regions
Location: 27508..83341
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| ACCK19_RS00115 (ACCK19_00115) | - | 28773..29561 (+) | 789 | WP_001104172.1 | two-component system regulatory protein YycI | - |
| ACCK19_RS00120 (ACCK19_00120) | - | 29951..30751 (+) | 801 | WP_000088648.1 | MBL fold metallo-hydrolase | - |
| ACCK19_RS00125 (ACCK19_00125) | adsA | 30979..33301 (+) | 2323 | Protein_22 | LPXTG-anchored adenosine synthase AdsA | - |
| ACCK19_RS00130 (ACCK19_00130) | rlmH | 33669..34148 (+) | 480 | WP_000704775.1 | 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH | - |
| ACCK19_RS00135 (ACCK19_00135) | - | 34470..35726 (+) | 1257 | WP_000566670.1 | MrcB family domain-containing protein | - |
| ACCK19_RS00140 (ACCK19_00140) | - | 36141..36380 (+) | 240 | WP_001282728.1 | hypothetical protein | - |
| ACCK19_RS00145 (ACCK19_00145) | - | 36412..37086 (-) | 675 | WP_001106057.1 | IS6-like element IS257 family transposase | - |
| ACCK19_RS00150 (ACCK19_00150) | - | 37177..38160 (-) | 984 | Protein_27 | protein rep | - |
| ACCK19_RS00155 (ACCK19_00155) | mobV | 38405..39667 (-) | 1263 | WP_000119405.1 | MobV family relaxase | - |
| ACCK19_RS00160 (ACCK19_00160) | bleO | 40174..40578 (-) | 405 | WP_001242578.1 | bleomycin binding protein | - |
| ACCK19_RS00165 (ACCK19_00165) | aadD1 | 40795..41565 (-) | 771 | WP_001795128.1 | aminoglycoside O-nucleotidyltransferase ANT(4')-Ia | - |
| ACCK19_RS00170 (ACCK19_00170) | - | 41758..42432 (-) | 675 | WP_001106057.1 | IS6-like element IS257 family transposase | - |
| ACCK19_RS00175 (ACCK19_00175) | - | 42697..43440 (+) | 744 | WP_000958858.1 | glycerophosphoryl diester phosphodiesterase | - |
| ACCK19_RS00180 (ACCK19_00180) | - | 43537..43965 (+) | 429 | WP_000872606.1 | MaoC family dehydratase | - |
| ACCK19_RS00185 (ACCK19_00185) | mecA | 44011..46020 (-) | 2010 | WP_001801873.1 | PBP2a family beta-lactam-resistant peptidoglycan transpeptidase MecA | - |
| ACCK19_RS00190 (ACCK19_00190) | - | 46117..47103 (+) | 987 | WP_001549960.1 | beta-lactam sensor/signal transducer MecR1 | - |
| ACCK19_RS00195 (ACCK19_00195) | - | 47090..47334 (+) | 245 | Protein_36 | type I restriction enzyme endonuclease domain-containing protein | - |
| ACCK19_RS00200 (ACCK19_00200) | - | 47325..48932 (-) | 1608 | Protein_37 | IS1182 family transposase | - |
| ACCK19_RS00205 (ACCK19_00205) | - | 48984..49490 (-) | 507 | WP_001092188.1 | DUF1643 domain-containing protein | - |
| ACCK19_RS00210 (ACCK19_00210) | - | 49505..49816 (-) | 312 | WP_000700851.1 | DUF960 family protein | - |
| ACCK19_RS00215 (ACCK19_00215) | - | 49903..50253 (-) | 351 | WP_000849672.1 | SAUGI family uracil-DNA glycosylase inhibitor | - |
| ACCK19_RS00220 (ACCK19_00220) | ccrB | 50775..52403 (-) | 1629 | Protein_41 | cassette chromosome recombinase CcrB | - |
| ACCK19_RS00225 (ACCK19_00225) | ccrA | 52425..53774 (-) | 1350 | WP_000815638.1 | cassette chromosome recombinase CcrA | Machinery gene |
| ACCK19_RS00230 (ACCK19_00230) | cch1 | 54008..55801 (-) | 1794 | WP_000195099.1 | cassette chromosome replicative helicase | - |
| ACCK19_RS00235 (ACCK19_00235) | ssb | 55801..56094 (-) | 294 | WP_000182688.1 | cassette chromosome ssDNA-binding protein | - |
| ACCK19_RS00240 (ACCK19_00240) | - | 56250..57317 (+) | 1068 | WP_001099283.1 | hypothetical protein | - |
| ACCK19_RS00245 (ACCK19_00245) | - | 57335..58849 (+) | 1515 | WP_000627204.1 | protein kinase | - |
| ACCK19_RS00250 (ACCK19_00250) | - | 58849..58998 (+) | 150 | WP_000369743.1 | hypothetical protein | - |
| ACCK19_RS00255 (ACCK19_00255) | - | 59300..61171 (+) | 1872 | WP_000666921.1 | zinc-ribbon domain-containing protein | - |
| ACCK19_RS00260 (ACCK19_00260) | - | 61164..62795 (+) | 1632 | WP_001036765.1 | hypothetical protein | - |
| ACCK19_RS00265 (ACCK19_00265) | - | 63189..63323 (-) | 135 | WP_001790628.1 | hypothetical protein | - |
| ACCK19_RS00270 (ACCK19_00270) | - | 63287..63379 (+) | 93 | WP_001790000.1 | hypothetical protein | - |
| ACCK19_RS00275 (ACCK19_00275) | - | 63664..64836 (+) | 1173 | WP_000195429.1 | IS256-like element IS256 family transposase | - |
| ACCK19_RS00280 (ACCK19_00280) | - | 64888..66605 (+) | 1718 | Protein_53 | DUF6119 family protein | - |
| ACCK19_RS00285 (ACCK19_00285) | - | 66699..67157 (-) | 459 | Protein_54 | tRNA-dihydrouridine synthase | - |
| ACCK19_RS00290 (ACCK19_00290) | - | 67167..67268 (-) | 102 | WP_001791873.1 | hypothetical protein | - |
| ACCK19_RS00295 (ACCK19_00295) | - | 67366..68121 (-) | 756 | WP_000355845.1 | sulfite exporter TauE/SafE family protein | - |
| ACCK19_RS00300 (ACCK19_00300) | cstR | 68121..68381 (-) | 261 | WP_001105087.1 | persulfide-sensing transcriptional repressor CstR | - |
| ACCK19_RS00305 (ACCK19_00305) | cstA | 68518..69585 (+) | 1068 | WP_000816129.1 | persulfide response sulfurtransferase CstA | - |
| ACCK19_RS00310 (ACCK19_00310) | cstB | 69616..70950 (+) | 1335 | WP_000465472.1 | persulfide dioxygenase-sulfurtransferase CstB | - |
| ACCK19_RS00315 (ACCK19_00315) | sqr | 70969..71601 (+) | 633 | Protein_60 | type II sulfide:quinone oxidoreductase Sqr | - |
| ACCK19_RS00320 (ACCK19_00320) | blaZ | 71903..72748 (-) | 846 | WP_205007973.1 | penicillin-hydrolyzing class A beta-lactamase BlaZ | - |
| ACCK19_RS00325 (ACCK19_00325) | blaR1 | 72855..74612 (+) | 1758 | WP_001096374.1 | beta-lactam sensor/signal transducer BlaR1 | - |
| ACCK19_RS00330 (ACCK19_00330) | blaI | 74602..74982 (+) | 381 | WP_001284656.1 | penicillinase repressor BlaI | - |
| ACCK19_RS00335 (ACCK19_00335) | - | 75246..75839 (+) | 594 | WP_000690636.1 | recombinase family protein | - |
| ACCK19_RS00340 (ACCK19_00340) | - | 75811..77253 (+) | 1443 | WP_000790709.1 | Mu transposase C-terminal domain-containing protein | - |
| ACCK19_RS00345 (ACCK19_00345) | - | 77246..78061 (+) | 816 | WP_000160701.1 | AAA family ATPase | - |
| ACCK19_RS00350 (ACCK19_00350) | sqr | 78148..78714 (+) | 567 | Protein_67 | type II sulfide:quinone oxidoreductase Sqr | - |
| ACCK19_RS00355 (ACCK19_00355) | - | 78981..79195 (-) | 215 | Protein_68 | universal stress protein | - |
| ACCK19_RS00360 (ACCK19_00360) | - | 79381..80367 (-) | 987 | WP_000662031.1 | tRNA-dihydrouridine synthase | - |
| ACCK19_RS00365 (ACCK19_00365) | - | 80676..80879 (+) | 204 | WP_000398679.1 | DUF6007 family protein | - |
| ACCK19_RS00370 (ACCK19_00370) | - | 80928..81224 (+) | 297 | WP_000201640.1 | TfoX/Sxy family protein | - |
| ACCK19_RS00375 (ACCK19_00375) | - | 81296..82516 (-) | 1221 | WP_000130764.1 | MFS transporter | - |
| ACCK19_RS00380 (ACCK19_00380) | - | 82509..83059 (-) | 551 | Protein_73 | flavodoxin family protein | - |
Sequence
Protein
Download Length: 449 a.a. Molecular weight: 52636.23 Da Isoelectric Point: 9.9639
>NTDB_id=1042075 ACCK19_RS00225 WP_000815638.1 52425..53774(-) (ccrA) [Staphylococcus aureus strain CUBIST-16]
MKQVIGYLRQSTMKQQSLAAQKQAIEAIAEKHHIQHINFYSDKQSGRKDNRSGYRQITQLIQQGQCDILCCYRLNRLHRN
LKNALKLIKLCQTYHVHILSVHDGYFDMDQAFDRLKLNIFISLAELESDNIGEQVRNGLQEKAKQGRLITTHAPFGYDYH
HGTFIINQNESPTVKAVFNYYIKGHGYKKIAQLLEEDNTYINRQPYQVRNIIINPNYCGRVNNQYGQFDNMFPSIVSTSI
YEQAQRLRSQKQTKQTSSDNQLKQKIKCPCCNATLTNMTIRKKNHTLRYYVCPKNMNASRFVCDFKGINAQTLEDKVLEV
CRDFYQNQRIYTKIKSAIDKRIKRQRNIEKHHTLTQEQLIEKLAQGIIDAETFREQTQSLRQQPQRTTSINGHQIQHIIQ
NIIQKRFTLNILYPYIETIHITKDKNLIGIYFKNEPLNIVNQTMQSSIA
MKQVIGYLRQSTMKQQSLAAQKQAIEAIAEKHHIQHINFYSDKQSGRKDNRSGYRQITQLIQQGQCDILCCYRLNRLHRN
LKNALKLIKLCQTYHVHILSVHDGYFDMDQAFDRLKLNIFISLAELESDNIGEQVRNGLQEKAKQGRLITTHAPFGYDYH
HGTFIINQNESPTVKAVFNYYIKGHGYKKIAQLLEEDNTYINRQPYQVRNIIINPNYCGRVNNQYGQFDNMFPSIVSTSI
YEQAQRLRSQKQTKQTSSDNQLKQKIKCPCCNATLTNMTIRKKNHTLRYYVCPKNMNASRFVCDFKGINAQTLEDKVLEV
CRDFYQNQRIYTKIKSAIDKRIKRQRNIEKHHTLTQEQLIEKLAQGIIDAETFREQTQSLRQQPQRTTSINGHQIQHIIQ
NIIQKRFTLNILYPYIETIHITKDKNLIGIYFKNEPLNIVNQTMQSSIA
Nucleotide
Download Length: 1350 bp
>NTDB_id=1042075 ACCK19_RS00225 WP_000815638.1 52425..53774(-) (ccrA) [Staphylococcus aureus strain CUBIST-16]
ATGAAACAAGTCATAGGCTATTTACGTCAAAGTACGATGAAACAACAATCTCTTGCAGCACAGAAACAAGCTATCGAAGC
AATAGCCGAAAAACATCATATTCAACATATCAACTTTTATAGCGACAAACAATCAGGTCGCAAAGATAATCGTAGTGGGT
ATCGACAAATAACACAATTAATTCAACAAGGACAGTGTGACATATTATGCTGTTATCGTCTTAATAGGTTGCATCGTAAT
CTGAAAAATGCATTAAAACTCATCAAATTATGTCAAACGTACCATGTTCATATCTTAAGCGTACATGATGGTTACTTTGA
TATGGATCAAGCTTTCGACCGACTCAAGCTTAATATCTTCATCAGTTTAGCCGAACTTGAATCGGATAACATTGGAGAAC
AAGTCAGAAATGGGCTTCAAGAAAAAGCAAAGCAAGGTCGATTGATTACAACACATGCACCTTTTGGTTACGATTATCAC
CACGGAACATTCATCATCAATCAAAATGAGTCACCAACGGTAAAGGCTGTATTCAATTATTACATTAAAGGCCATGGTTA
TAAGAAAATTGCACAGTTATTAGAAGAAGATAACACGTATATCAATCGACAACCCTATCAAGTTCGTAACATTATCATCA
ATCCTAATTATTGTGGTCGTGTCAACAATCAATATGGCCAATTCGACAATATGTTTCCTTCTATTGTTTCCACAAGTATA
TATGAGCAAGCGCAGAGACTTCGATCGCAAAAACAAACCAAACAGACATCTTCGGATAATCAACTCAAACAAAAAATCAA
ATGCCCATGTTGTAATGCAACACTTACAAATATGACCATTAGAAAAAAGAATCATACATTACGTTACTACGTCTGTCCTA
AAAACATGAATGCTTCACGCTTTGTCTGTGATTTTAAAGGCATCAATGCACAAACACTTGAAGATAAAGTATTAGAAGTG
TGCCGAGACTTTTATCAAAATCAACGCATCTACACAAAAATTAAAAGTGCGATTGACAAACGCATCAAAAGACAAAGAAA
CATAGAAAAACATCACACATTGACTCAAGAACAACTGATAGAAAAGTTGGCACAAGGCATCATTGATGCAGAAACGTTCA
GAGAGCAAACACAATCATTACGTCAACAACCGCAACGCACTACATCTATCAATGGGCATCAAATACAACACATCATTCAA
AATATTATTCAAAAACGTTTCACGTTAAACATATTGTACCCCTATATTGAAACCATTCACATTACGAAAGATAAAAATCT
TATAGGAATCTATTTCAAAAATGAACCACTCAATATTGTCAATCAAACCATGCAATCATCGATTGCATAA
ATGAAACAAGTCATAGGCTATTTACGTCAAAGTACGATGAAACAACAATCTCTTGCAGCACAGAAACAAGCTATCGAAGC
AATAGCCGAAAAACATCATATTCAACATATCAACTTTTATAGCGACAAACAATCAGGTCGCAAAGATAATCGTAGTGGGT
ATCGACAAATAACACAATTAATTCAACAAGGACAGTGTGACATATTATGCTGTTATCGTCTTAATAGGTTGCATCGTAAT
CTGAAAAATGCATTAAAACTCATCAAATTATGTCAAACGTACCATGTTCATATCTTAAGCGTACATGATGGTTACTTTGA
TATGGATCAAGCTTTCGACCGACTCAAGCTTAATATCTTCATCAGTTTAGCCGAACTTGAATCGGATAACATTGGAGAAC
AAGTCAGAAATGGGCTTCAAGAAAAAGCAAAGCAAGGTCGATTGATTACAACACATGCACCTTTTGGTTACGATTATCAC
CACGGAACATTCATCATCAATCAAAATGAGTCACCAACGGTAAAGGCTGTATTCAATTATTACATTAAAGGCCATGGTTA
TAAGAAAATTGCACAGTTATTAGAAGAAGATAACACGTATATCAATCGACAACCCTATCAAGTTCGTAACATTATCATCA
ATCCTAATTATTGTGGTCGTGTCAACAATCAATATGGCCAATTCGACAATATGTTTCCTTCTATTGTTTCCACAAGTATA
TATGAGCAAGCGCAGAGACTTCGATCGCAAAAACAAACCAAACAGACATCTTCGGATAATCAACTCAAACAAAAAATCAA
ATGCCCATGTTGTAATGCAACACTTACAAATATGACCATTAGAAAAAAGAATCATACATTACGTTACTACGTCTGTCCTA
AAAACATGAATGCTTCACGCTTTGTCTGTGATTTTAAAGGCATCAATGCACAAACACTTGAAGATAAAGTATTAGAAGTG
TGCCGAGACTTTTATCAAAATCAACGCATCTACACAAAAATTAAAAGTGCGATTGACAAACGCATCAAAAGACAAAGAAA
CATAGAAAAACATCACACATTGACTCAAGAACAACTGATAGAAAAGTTGGCACAAGGCATCATTGATGCAGAAACGTTCA
GAGAGCAAACACAATCATTACGTCAACAACCGCAACGCACTACATCTATCAATGGGCATCAAATACAACACATCATTCAA
AATATTATTCAAAAACGTTTCACGTTAAACATATTGTACCCCTATATTGAAACCATTCACATTACGAAAGATAAAAATCT
TATAGGAATCTATTTCAAAAATGAACCACTCAATATTGTCAATCAAACCATGCAATCATCGATTGCATAA
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| ccrA | Staphylococcus aureus N315 |
97.55 |
100 |
0.976 |
| ccrA | Staphylococcus aureus COL |
75.501 |
100 |
0.755 |