Detailed information NTG1041945

Bioinformatically predicted

Overview

• Name: ccrA
• Type: Machinery gene
• Locus tag: ACCK22_RS00485
• Genome accession: NZ_CP168085
• Coordinates: 99813..101162 (-)
• Length: 449 a.a.
• NCBI ID: WP_000815645.1
• Uniprot ID: -
• Organism: Staphylococcus aureus strain CUBIST-27
• Function: promote SCCmec transfer (predicted from homology) Homologous recombination

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type	MGE coordinates	Gene coordinates	Relative position	Distance (bp)
SCCmec	79797..101162	99813..101162	within	0

Gene organization within MGE regions

Location: 79797..101162

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ACCK22_RS00380 (ACCK22_00380)	mecA	79797..81806 (-)	2010	WP_001801873.1	PBP2a family beta-lactam-resistant peptidoglycan transpeptidase MecA	-
ACCK22_RS00385 (ACCK22_00385)	mecR1	81903..83660 (+)	1758	WP_000952923.1	beta-lactam sensor/signal transducer MecR1	-
ACCK22_RS00390 (ACCK22_00390)	mecI	83660..84058 (+)	399	WP_064139837.1	mecA-type methicillin resistance repressor MecI	-
ACCK22_RS00395 (ACCK22_00395)	psm-mec	84116..84184 (-)	69	WP_014532405.1	phenol-soluble modulin PSM-mec	-
ACCK22_RS00400 (ACCK22_00400)	-	84518..85648 (+)	1131	WP_010922808.1	ROK family transcriptional regulator	-
ACCK22_RS00405 (ACCK22_00405)	cstB	85762..87096 (-)	1335	Protein_78	persulfide dioxygenase-sulfurtransferase CstB	-
ACCK22_RS00410 (ACCK22_00410)	-	87129..88193 (-)	1065	WP_000438836.1	DsrE/DsrF/DrsH-like family protein	-
ACCK22_RS00415 (ACCK22_00415)	cstR	88329..88589 (+)	261	WP_000220507.1	persulfide-sensing transcriptional repressor CstR	-
ACCK22_RS00420 (ACCK22_00420)	-	88589..89227 (+)	639	Protein_81	sulfite exporter TauE/SafE family protein	-
ACCK22_RS00425 (ACCK22_00425)	-	89572..90234 (-)	663	WP_001092058.1	class I SAM-dependent methyltransferase	-
ACCK22_RS00430 (ACCK22_00430)	-	90626..90685 (+)	60	WP_010959190.1	erythromycin resistance leader peptide	-
ACCK22_RS00435 (ACCK22_00435)	erm(A)	90768..91499 (+)	732	WP_001072201.1	23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(A)	-
ACCK22_RS00440 (ACCK22_00440)	-	91625..92407 (-)	783	WP_000067268.1	aminoglycoside nucleotidyltransferase ANT(9)-Ia	-
ACCK22_RS00445 (ACCK22_00445)	-	92558..92935 (-)	378	WP_000361059.1	DUF6262 family protein	-
ACCK22_RS00450 (ACCK22_00450)	-	92942..94834 (-)	1893	WP_001557544.1	site-specific integrase	-
ACCK22_RS00455 (ACCK22_00455)	-	94831..95916 (-)	1086	WP_000868132.1	tyrosine-type recombinase/integrase	-
ACCK22_RS00460 (ACCK22_00460)	-	96035..96352 (-)	318	WP_000659050.1	JAB domain-containing protein	-
ACCK22_RS00465 (ACCK22_00465)	-	96373..96879 (-)	507	WP_001092170.1	DUF1643 domain-containing protein	-
ACCK22_RS00470 (ACCK22_00470)	-	96897..97208 (-)	312	WP_000700853.1	DUF960 family protein	-
ACCK22_RS00475 (ACCK22_00475)	-	97295..97645 (-)	351	WP_000859155.1	SAUGI family uracil-DNA glycosylase inhibitor	-
ACCK22_RS00480 (ACCK22_00480)	ccrB	98163..99791 (-)	1629	WP_001186602.1	cassette chromosome recombinase CcrB	Machinery gene
ACCK22_RS00485 (ACCK22_00485)	ccrA	99813..101162 (-)	1350	WP_000815645.1	cassette chromosome recombinase CcrA	Machinery gene

Sequence

Protein

• Length: 449 a.a.
• Molecular weight: 52579.19 Da
• Isoelectric Point: 9.9534

>NTDB_id=1041945 ACCK22_RS00485 WP_000815645.1 99813..101162(-) (ccrA) [Staphylococcus aureus strain CUBIST-27]
MKQVIGYLRQSTMKQQSLAAQKQAIEAIAEKHHIQHINFYSDKQSGRKDNRSGYRQMTQLIQQGQCDILCCYRLNRLHRN
LKNALKLIKLCQTYHVHILSVHDGYFDMDQAFDRFKLNIFISLAELESDNIGEQVRNGLQEKAKQGRLITTHAPFGYEYH
NGAFIINQNESPTVKAVFNYYIKGHGYKKIAQLLEEDNTYINRQPYQVRNIIINPNYCGRVNNQYGQFDNMFPSIVSTSI
YEQAQRLRSQKQIKQTSSDNQLKQKIKCPCCNTTLTNMTVRKKNHTLRYYVCPKNMNASRFVCDFKGINAQTLEDKVLEV
CKDFYQNQRIYTKIKGAIDKRIKRQKNIEKHHTLTQEQLIEKLAQGIIDAETFREQTQSLRQQPQRTTSINGHQIQHTIQ
NIIQKRFTLNILYPYIETIHITKDKNLIGIYFKNEPLNIVNQTMQSSIA

Nucleotide

• Length: 1350 bp

>NTDB_id=1041945 ACCK22_RS00485 WP_000815645.1 99813..101162(-) (ccrA) [Staphylococcus aureus strain CUBIST-27]
ATGAAACAAGTCATAGGCTATTTACGTCAAAGTACGATGAAACAACAATCTCTTGCAGCACAGAAACAGGCTATCGAAGC
AATAGCCGAAAAACATCATATTCAACATATCAACTTTTATAGCGACAAACAATCAGGACGCAAAGATAATCGTAGTGGGT
ATCGACAAATGACGCAATTAATTCAACAAGGGCAATGTGACATATTATGTTGTTATCGTCTTAATAGATTACATCGTAAT
CTGAAAAATGCATTAAAACTCATCAAATTATGTCAAACATACCATGTTCATATCTTAAGCGTACACGATGGTTACTTTGA
TATGGATCAAGCTTTCGACCGATTCAAGCTTAATATTTTTATCAGCTTGGCCGAACTTGAATCAGATAACATTGGAGAAC
AAGTCAGAAATGGGCTTCAAGAAAAAGCAAAGCAAGGTCGATTGATTACAACCCATGCGCCCTTTGGTTACGAATATCAC
AACGGAGCATTCATCATCAATCAAAATGAGTCACCAACGGTAAAGGCTGTATTCAATTATTACATTAAAGGTCATGGTTA
TAAGAAAATTGCACAGTTATTAGAAGAAGATAACACGTATATCAATCGACAACCCTATCAAGTTCGTAACATTATCATCA
ATCCTAATTATTGTGGTCGTGTCAACAATCAATATGGCCAATTCGACAATATGTTTCCTTCTATTGTTTCCACAAGTATA
TATGAGCAAGCGCAGAGACTTCGATCGCAAAAACAAATCAAACAGACATCTTCGGATAACCAACTAAAACAAAAAATCAA
ATGCCCATGTTGTAATACAACACTTACGAATATGACCGTTAGAAAAAAGAATCATACATTACGTTACTACGTCTGTCCTA
AAAACATGAATGCTTCTCGCTTTGTCTGTGATTTTAAAGGCATCAATGCACAAACACTTGAAGATAAAGTATTAGAAGTG
TGCAAAGACTTTTATCAAAATCAACGCATCTACACAAAAATTAAAGGTGCGATTGACAAACGCATCAAAAGACAAAAAAA
CATAGAAAAACATCACACATTGACTCAAGAACAACTGATAGAAAAGTTGGCACAAGGCATCATCGATGCAGAAACGTTCA
GAGAACAAACGCAATCATTACGTCAACAACCGCAACGCACTACATCTATCAATGGACATCAAATACAACACACCATTCAA
AATATTATTCAAAAACGTTTCACGTTAAACATATTGTACCCCTATATTGAAACCATTCACATTACGAAAGATAAAAATCT
TATAGGAATCTATTTCAAAAATGAACCACTCAATATCGTCAATCAAACCATGCAATCATCGATTGCATAA

Domains

Predicted by InterproScan.

• Resolvase, N terminal domain (Resolvase) (4-147)

• Recombinase (Recombinase) (169-250)

• Recombinase zinc beta ribbon domain (Zn_ribbon_recom) (262-322)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
ccrA	Staphylococcus aureus N315	99.777	100	0.998
ccrA	Staphylococcus aureus COL	74.61	100	0.746