Detailed information    

insolico Bioinformatically predicted

Overview

Name   agrA   Type   Regulator
Locus tag   ACCK12_RS10715 Genome accession   NZ_CP167990
Coordinates   2136400..2137116 (+) Length   238 a.a.
NCBI ID   WP_000688492.1    Uniprot ID   A0A7U7IEW1
Organism   Staphylococcus aureus strain CUBIST-4     
Function   promote expression of competence genes (predicted from homology)   
Competence regulation

Genomic Context

Location: 2131400..2142116
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ACCK12_RS10685 (ACCK12_10685) - 2131619..2132245 (+) 627 WP_000522384.1 nitroreductase family protein -
  ACCK12_RS10690 (ACCK12_10690) - 2132606..2133391 (+) 786 WP_000867960.1 carbon-nitrogen family hydrolase -
  ACCK12_RS10695 (ACCK12_10695) - 2133988..2134122 (-) 135 WP_001549197.1 delta-lysin family phenol-soluble modulin -
  ACCK12_RS10700 (ACCK12_10700) agrB 2134358..2134927 (+) 570 WP_001105707.1 accessory gene regulator AgrB -
  ACCK12_RS10705 (ACCK12_10705) agrD 2134924..2135064 (+) 141 WP_001093929.1 cyclic lactone autoinducer peptide AgrD -
  ACCK12_RS10710 (ACCK12_10710) agrC 2135089..2136381 (+) 1293 WP_001549202.1 quorum-sensing sensor histidine kinase AgrC -
  ACCK12_RS10715 (ACCK12_10715) agrA 2136400..2137116 (+) 717 WP_000688492.1 quorum-sensing response regulator AgrA Regulator
  ACCK12_RS10720 (ACCK12_10720) - 2137188..2137295 (+) 108 WP_001790167.1 hypothetical protein -
  ACCK12_RS10725 (ACCK12_10725) - 2137483..2138443 (-) 961 Protein_2079 carbohydrate kinase -
  ACCK12_RS10730 (ACCK12_10730) - 2138440..2139924 (-) 1485 WP_000141414.1 sucrose-6-phosphate hydrolase -
  ACCK12_RS10735 (ACCK12_10735) - 2140073..2141023 (-) 951 WP_000790330.1 LacI family DNA-binding transcriptional regulator -

Sequence

Protein


Download         Length: 238 a.a.        Molecular weight: 27905.90 Da        Isoelectric Point: 6.0927

>NTDB_id=1040952 ACCK12_RS10715 WP_000688492.1 2136400..2137116(+) (agrA) [Staphylococcus aureus strain CUBIST-4]
MKIFICEDDPKQRENMVTIIKNYIMIEEKPMEIALATDNPYEVLEQAKNMNDIGCYFLDIQLSTDINGIKLGSEIRKHDP
VGNIIFVTSHSELTYLTFVYKVAAMDFIFKDDPAELRTRIIDCLETAHTRLQLLSKDNSVETIELKRGSNSVYVQYDDIM
FFESSTKSHRLIAHLDNRQIEFYGNLKELSQLDDRFFRCHNSFVVNRHNIESIDSKERIVYFKNKEHCYASVRNVKKI

Nucleotide


Download         Length: 717 bp        

>NTDB_id=1040952 ACCK12_RS10715 WP_000688492.1 2136400..2137116(+) (agrA) [Staphylococcus aureus strain CUBIST-4]
ATGAAAATTTTCATTTGCGAAGACGATCCAAAACAAAGAGAAAACATGGTTACCATTATTAAAAATTATATAATGATAGA
AGAAAAGCCTATGGAAATTGCCCTCGCAACTGATAATCCTTATGAGGTGCTTGAGCAAGCTAAAAATATGAATGACATAG
GCTGTTACTTTTTAGATATTCAACTTTCAACTGATATTAATGGTATCAAATTAGGCAGTGAAATTCGTAAGCATGACCCA
GTTGGTAACATTATTTTCGTTACGAGTCACAGTGAACTTACCTATTTAACATTTGTCTACAAAGTTGCAGCGATGGATTT
TATTTTTAAAGATGATCCAGCTGAATTAAGAACTCGAATTATAGACTGTTTAGAAACTGCACATACACGCTTACAATTGT
TGTCTAAAGATAATAGCGTTGAAACGATTGAATTAAAACGTGGCAGTAATTCAGTGTATGTTCAATATGATGATATTATG
TTTTTTGAATCATCAACAAAATCTCACAGACTCATTGCCCATTTAGATAACCGTCAAATTGAATTTTATGGTAATTTAAA
AGAACTGAGTCAATTAGATGATCGTTTCTTTAGATGTCATAATAGCTTTGTCGTCAATCGCCATAATATTGAATCTATAG
ATTCGAAAGAGCGAATTGTCTATTTTAAAAATAAAGAACACTGCTATGCATCGGTGAGAAACGTTAAAAAAATATAA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(3-120)

LytTr DNA-binding domain (LytTR)

(151-237)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A7U7IEW1

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  agrA Staphylococcus aureus N315

100

100

1

Multiple sequence alignment