Detailed information
Bioinformatically predicted
Overview
| Name | ccrB | Type | Machinery gene |
| Locus tag | ACCK13_RS00435 | Genome accession | NZ_CP167764 |
| Coordinates | 62355..63983 (-) | Length | 542 a.a. |
| NCBI ID | WP_001186602.1 | Uniprot ID | Q9XB94 |
| Organism | Staphylococcus aureus strain CUBIST-10 | ||
| Function | promote SCCmec transfer (predicted from homology) Homologous recombination |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| ICE | 57134..100845 | 62355..63983 | within | 0 |
| SCCmec | 44014..65354 | 62355..63983 | within | 0 |
Gene organization within MGE regions
Location: 44014..100845
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| ACCK13_RS00335 (ACCK13_00335) | mecA | 44014..46023 (-) | 2010 | WP_001801873.1 | PBP2a family beta-lactam-resistant peptidoglycan transpeptidase MecA | - |
| ACCK13_RS00340 (ACCK13_00340) | mecR1 | 46120..47877 (+) | 1758 | WP_000952923.1 | beta-lactam sensor/signal transducer MecR1 | - |
| ACCK13_RS00345 (ACCK13_00345) | mecI | 47877..48248 (+) | 372 | WP_000369214.1 | mecA-type methicillin resistance repressor MecI | - |
| ACCK13_RS00350 (ACCK13_00350) | psm-mec | 48333..48401 (-) | 69 | WP_014532405.1 | phenol-soluble modulin PSM-mec | - |
| ACCK13_RS00355 (ACCK13_00355) | - | 48735..49865 (+) | 1131 | WP_010922808.1 | ROK family transcriptional regulator | - |
| ACCK13_RS00360 (ACCK13_00360) | cstB | 49979..51313 (-) | 1335 | Protein_39 | persulfide dioxygenase-sulfurtransferase CstB | - |
| ACCK13_RS00365 (ACCK13_00365) | - | 51346..52410 (-) | 1065 | WP_000438836.1 | DsrE/DsrF/DrsH-like family protein | - |
| ACCK13_RS00370 (ACCK13_00370) | cstR | 52546..52806 (+) | 261 | WP_000220507.1 | persulfide-sensing transcriptional repressor CstR | - |
| ACCK13_RS00375 (ACCK13_00375) | - | 52806..53444 (+) | 639 | Protein_42 | sulfite exporter TauE/SafE family protein | - |
| ACCK13_RS00380 (ACCK13_00380) | - | 53789..54451 (-) | 663 | WP_001092058.1 | class I SAM-dependent methyltransferase | - |
| ACCK13_RS00385 (ACCK13_00385) | - | 54843..54902 (+) | 60 | WP_010959190.1 | erythromycin resistance leader peptide | - |
| ACCK13_RS00390 (ACCK13_00390) | erm(A) | 54960..55691 (+) | 732 | WP_001072201.1 | 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(A) | - |
| ACCK13_RS00395 (ACCK13_00395) | - | 55817..56599 (-) | 783 | WP_000067268.1 | aminoglycoside nucleotidyltransferase ANT(9)-Ia | - |
| ACCK13_RS00400 (ACCK13_00400) | - | 56750..57127 (-) | 378 | WP_000361059.1 | DUF6262 family protein | - |
| ACCK13_RS00405 (ACCK13_00405) | - | 57134..59026 (-) | 1893 | WP_001557544.1 | site-specific integrase | - |
| ACCK13_RS00410 (ACCK13_00410) | - | 59023..60108 (-) | 1086 | WP_000868132.1 | tyrosine-type recombinase/integrase | - |
| ACCK13_RS00415 (ACCK13_00415) | - | 60227..60544 (-) | 318 | WP_000659050.1 | JAB domain-containing protein | - |
| ACCK13_RS00420 (ACCK13_00420) | - | 60565..61071 (-) | 507 | WP_001092169.1 | DUF1643 domain-containing protein | - |
| ACCK13_RS00425 (ACCK13_00425) | - | 61089..61400 (-) | 312 | WP_000700853.1 | DUF960 family protein | - |
| ACCK13_RS00430 (ACCK13_00430) | - | 61487..61837 (-) | 351 | WP_000859155.1 | SAUGI family uracil-DNA glycosylase inhibitor | - |
| ACCK13_RS00435 (ACCK13_00435) | ccrB | 62355..63983 (-) | 1629 | WP_001186602.1 | cassette chromosome recombinase CcrB | Machinery gene |
| ACCK13_RS00440 (ACCK13_00440) | ccrA | 64005..65354 (-) | 1350 | WP_000815646.1 | cassette chromosome recombinase CcrA | Machinery gene |
| ACCK13_RS00445 (ACCK13_00445) | cch1 | 65588..67381 (-) | 1794 | WP_000195105.1 | cassette chromosome replicative helicase | - |
| ACCK13_RS00450 (ACCK13_00450) | ssb | 67381..67677 (-) | 297 | WP_000273824.1 | cassette chromosome ssDNA-binding protein | - |
| ACCK13_RS00455 (ACCK13_00455) | - | 67870..68916 (-) | 1047 | WP_001060127.1 | hypothetical protein | - |
| ACCK13_RS00460 (ACCK13_00460) | - | 69167..70308 (-) | 1142 | Protein_59 | IS3-like element ISSau4 family transposase | - |
| ACCK13_RS00465 (ACCK13_00465) | - | 70819..71754 (-) | 936 | Protein_60 | YfcC family protein | - |
| ACCK13_RS00470 (ACCK13_00470) | - | 72467..73162 (-) | 696 | WP_000858967.1 | response regulator transcription factor | - |
| ACCK13_RS00475 (ACCK13_00475) | - | 73137..75806 (-) | 2670 | WP_000446429.1 | sensor histidine kinase KdpD | - |
| ACCK13_RS00480 (ACCK13_00480) | kdpF | 75973..76053 (+) | 81 | WP_000631574.1 | K(+)-transporting ATPase subunit F | - |
| ACCK13_RS00485 (ACCK13_00485) | kdpA | 76074..77750 (+) | 1677 | WP_000029430.1 | potassium-transporting ATPase subunit KdpA | - |
| ACCK13_RS00490 (ACCK13_00490) | - | 77769..79790 (+) | 2022 | WP_000852430.1 | K(+)-transporting ATPase subunit B | - |
| ACCK13_RS00495 (ACCK13_00495) | - | 79806..80363 (+) | 558 | WP_001193482.1 | K(+)-transporting ATPase subunit C | - |
| ACCK13_RS00500 (ACCK13_00500) | - | 80908..81777 (-) | 870 | WP_000626133.1 | hypothetical protein | - |
| ACCK13_RS00505 (ACCK13_00505) | - | 81787..82683 (-) | 897 | WP_000411461.1 | DUF927 domain-containing protein | - |
| ACCK13_RS00510 (ACCK13_00510) | - | 83802..84428 (-) | 627 | WP_001176969.1 | hypothetical protein | - |
| ACCK13_RS00515 (ACCK13_00515) | - | 84543..86051 (+) | 1509 | WP_001001347.1 | protein kinase | - |
| ACCK13_RS00520 (ACCK13_00520) | - | 86301..86435 (-) | 135 | WP_001790628.1 | hypothetical protein | - |
| ACCK13_RS00525 (ACCK13_00525) | - | 86399..86491 (+) | 93 | WP_001790000.1 | hypothetical protein | - |
| ACCK13_RS00530 (ACCK13_00530) | - | 86638..88383 (+) | 1746 | WP_000700190.1 | DUF6119 family protein | - |
| ACCK13_RS00535 (ACCK13_00535) | - | 88481..88836 (-) | 356 | Protein_74 | tRNA-dihydrouridine synthase | - |
| ACCK13_RS00540 (ACCK13_00540) | - | 89141..89229 (-) | 89 | Protein_75 | hypothetical protein | - |
| ACCK13_RS00545 (ACCK13_00545) | - | 89327..90082 (-) | 756 | WP_000355845.1 | sulfite exporter TauE/SafE family protein | - |
| ACCK13_RS00550 (ACCK13_00550) | cstR | 90082..90342 (-) | 261 | WP_001105088.1 | persulfide-sensing transcriptional repressor CstR | - |
| ACCK13_RS00555 (ACCK13_00555) | cstA | 90479..91543 (+) | 1065 | WP_000816133.1 | persulfide response sulfurtransferase CstA | - |
| ACCK13_RS00560 (ACCK13_00560) | cstB | 91574..92908 (+) | 1335 | WP_000465472.1 | persulfide dioxygenase-sulfurtransferase CstB | - |
| ACCK13_RS00565 (ACCK13_00565) | sqr | 92927..94120 (+) | 1194 | WP_001033018.1 | type II sulfide:quinone oxidoreductase Sqr | - |
| ACCK13_RS00570 (ACCK13_00570) | - | 94387..94601 (-) | 215 | Protein_81 | universal stress protein | - |
| ACCK13_RS00575 (ACCK13_00575) | - | 94787..95773 (-) | 987 | WP_000662022.1 | tRNA-dihydrouridine synthase | - |
| ACCK13_RS00580 (ACCK13_00580) | - | 96082..96285 (+) | 204 | WP_000389759.1 | DUF6007 family protein | - |
| ACCK13_RS00585 (ACCK13_00585) | - | 96334..96630 (+) | 297 | WP_000201644.1 | TfoX/Sxy family protein | - |
| ACCK13_RS00590 (ACCK13_00590) | - | 96838..97440 (+) | 603 | WP_000908956.1 | hypothetical protein | - |
| ACCK13_RS00595 (ACCK13_00595) | - | 97707..100845 (+) | 3139 | Protein_86 | AAA domain-containing protein | - |
Sequence
Protein
Download Length: 542 a.a. Molecular weight: 62664.84 Da Isoelectric Point: 9.8600
>NTDB_id=1039166 ACCK13_RS00435 WP_001186602.1 62355..63983(-) (ccrB) [Staphylococcus aureus strain CUBIST-10]
MQQLKTKRVGIYVRVSTEMQSTEGYSIDGQINQIKEYCDFHHFEVKDIYADRGISGKSMNRPELQRILKDAKEGYIDCVM
VYKTNRLARNTSDLLKIVEDLHKQNVEFFSLSERMEVNTSSGKLMLQILASFSEFERNNIVENVFMGQTRRAQEGYYQGN
LPLGYDKIPNSKHELMINQHEANIVKYIFESYAKGHGYRKIANALNHKGYVTKKGKPFSISSITYILANPFYIGKIQFAK
YKDWSEKRRKGLNDKPVIAEGKHSPIINQDLWDKVQMRKKQVSQKPQVHGKGTNLLTGIIHCPQCGAPMAASNTTNTLKD
GTKKRIRYYSCSNFRNKGSKVCSANSVRADVIEDYVMKQILEIVKSDKVIQRVVTHVNQENQVDGAALHHDIAYKQQQYD
EVQIKLNNLIKTIEDNPDLTSVIRPSIQKYEKQLNDITNQINQLKNQQNEDKPLFDAKEISKLLQHIFHDIKHIEKSRLK
ALYLSVIDRIDIKKDGNHKKQFYVTLKLNNEIIKQLFNNKQLDEVHLSTSSLFLPQTLYLTI
MQQLKTKRVGIYVRVSTEMQSTEGYSIDGQINQIKEYCDFHHFEVKDIYADRGISGKSMNRPELQRILKDAKEGYIDCVM
VYKTNRLARNTSDLLKIVEDLHKQNVEFFSLSERMEVNTSSGKLMLQILASFSEFERNNIVENVFMGQTRRAQEGYYQGN
LPLGYDKIPNSKHELMINQHEANIVKYIFESYAKGHGYRKIANALNHKGYVTKKGKPFSISSITYILANPFYIGKIQFAK
YKDWSEKRRKGLNDKPVIAEGKHSPIINQDLWDKVQMRKKQVSQKPQVHGKGTNLLTGIIHCPQCGAPMAASNTTNTLKD
GTKKRIRYYSCSNFRNKGSKVCSANSVRADVIEDYVMKQILEIVKSDKVIQRVVTHVNQENQVDGAALHHDIAYKQQQYD
EVQIKLNNLIKTIEDNPDLTSVIRPSIQKYEKQLNDITNQINQLKNQQNEDKPLFDAKEISKLLQHIFHDIKHIEKSRLK
ALYLSVIDRIDIKKDGNHKKQFYVTLKLNNEIIKQLFNNKQLDEVHLSTSSLFLPQTLYLTI
Nucleotide
Download Length: 1629 bp
>NTDB_id=1039166 ACCK13_RS00435 WP_001186602.1 62355..63983(-) (ccrB) [Staphylococcus aureus strain CUBIST-10]
ATGCAACAACTTAAAACAAAACGTGTCGGTATCTATGTACGTGTATCAACAGAAATGCAAAGCACAGAAGGTTATAGTAT
CGACGGACAAATCAATCAAATCAAAGAATACTGTGACTTCCATCATTTTGAAGTTAAAGATATATACGCTGACCGTGGTA
TTTCAGGTAAATCTATGAATCGACCTGAGCTCCAACGTATATTGAAGGATGCGAAAGAAGGCTATATCGACTGTGTTATG
GTCTACAAAACAAACCGATTAGCTCGTAATACATCTGATCTTCTCAAAATTGTCGAAGATTTACACAAACAAAATGTCGA
ATTTTTCAGTTTATCAGAGCGTATGGAAGTCAATACTTCATCGGGTAAGCTCATGTTACAAATACTTGCGAGTTTCTCAG
AATTCGAACGTAATAACATTGTCGAGAATGTATTTATGGGTCAAACGAGACGTGCCCAAGAAGGCTATTATCAAGGCAAT
TTGCCGCTGGGCTATGACAAAATACCTAATAGTAAACATGAACTGATGATTAATCAACATGAAGCTAATATTGTGAAATA
TATATTCGAGTCCTATGCCAAAGGCCATGGCTATCGTAAAATAGCCAATGCATTAAATCACAAAGGCTATGTCACTAAAA
AGGGTAAACCTTTTAGTATTAGTTCTATCACATATATATTAGCTAACCCATTCTATATCGGCAAAATTCAATTTGCGAAA
TACAAAGATTGGAGTGAAAAACGTCGTAAAGGGCTTAATGATAAACCAGTGATAGCTGAAGGTAAGCATTCCCCCATTAT
TAATCAAGATTTATGGGATAAAGTACAAATGCGTAAAAAACAAGTCAGTCAAAAACCCCAAGTCCATGGCAAAGGAACGA
ATCTGCTTACAGGCATTATTCACTGTCCCCAATGTGGCGCACCTATGGCAGCAAGCAATACCACGAATACACTTAAAGAC
GGGACTAAGAAACGTATTCGTTACTATTCATGTAGTAATTTTCGGAACAAGGGTTCCAAAGTATGTTCGGCAAACAGTGT
AAGAGCTGATGTGATTGAAGATTATGTGATGAAGCAAATACTTGAAATAGTCAAAAGTGATAAAGTCATTCAACGCGTAG
TAACACACGTCAATCAAGAAAATCAAGTTGATGGCGCTGCACTTCATCACGATATTGCTTATAAGCAACAACAATATGAT
GAAGTACAAATCAAACTAAATAACTTGATTAAAACCATCGAGGATAATCCGGACTTAACATCAGTAATCAGACCAAGTAT
TCAAAAATATGAAAAGCAACTCAATGACATTACGAATCAAATCAACCAACTCAAAAATCAACAAAATGAAGATAAGCCTT
TATTTGATGCCAAAGAAATCAGTAAACTATTACAACACATCTTTCATGATATTAAGCACATAGAAAAATCTCGACTCAAA
GCATTGTATCTATCAGTGATTGATCGCATTGATATTAAAAAAGATGGTAATCATAAAAAACAATTCTATGTCACACTCAA
ACTTAATAACGAAATCATAAAACAACTTTTCAATAATAAACAACTCGACGAAGTGCATCTCAGCACTTCGTCTTTGTTTT
TGCCCCAAACACTATATCTTACTATTTAG
ATGCAACAACTTAAAACAAAACGTGTCGGTATCTATGTACGTGTATCAACAGAAATGCAAAGCACAGAAGGTTATAGTAT
CGACGGACAAATCAATCAAATCAAAGAATACTGTGACTTCCATCATTTTGAAGTTAAAGATATATACGCTGACCGTGGTA
TTTCAGGTAAATCTATGAATCGACCTGAGCTCCAACGTATATTGAAGGATGCGAAAGAAGGCTATATCGACTGTGTTATG
GTCTACAAAACAAACCGATTAGCTCGTAATACATCTGATCTTCTCAAAATTGTCGAAGATTTACACAAACAAAATGTCGA
ATTTTTCAGTTTATCAGAGCGTATGGAAGTCAATACTTCATCGGGTAAGCTCATGTTACAAATACTTGCGAGTTTCTCAG
AATTCGAACGTAATAACATTGTCGAGAATGTATTTATGGGTCAAACGAGACGTGCCCAAGAAGGCTATTATCAAGGCAAT
TTGCCGCTGGGCTATGACAAAATACCTAATAGTAAACATGAACTGATGATTAATCAACATGAAGCTAATATTGTGAAATA
TATATTCGAGTCCTATGCCAAAGGCCATGGCTATCGTAAAATAGCCAATGCATTAAATCACAAAGGCTATGTCACTAAAA
AGGGTAAACCTTTTAGTATTAGTTCTATCACATATATATTAGCTAACCCATTCTATATCGGCAAAATTCAATTTGCGAAA
TACAAAGATTGGAGTGAAAAACGTCGTAAAGGGCTTAATGATAAACCAGTGATAGCTGAAGGTAAGCATTCCCCCATTAT
TAATCAAGATTTATGGGATAAAGTACAAATGCGTAAAAAACAAGTCAGTCAAAAACCCCAAGTCCATGGCAAAGGAACGA
ATCTGCTTACAGGCATTATTCACTGTCCCCAATGTGGCGCACCTATGGCAGCAAGCAATACCACGAATACACTTAAAGAC
GGGACTAAGAAACGTATTCGTTACTATTCATGTAGTAATTTTCGGAACAAGGGTTCCAAAGTATGTTCGGCAAACAGTGT
AAGAGCTGATGTGATTGAAGATTATGTGATGAAGCAAATACTTGAAATAGTCAAAAGTGATAAAGTCATTCAACGCGTAG
TAACACACGTCAATCAAGAAAATCAAGTTGATGGCGCTGCACTTCATCACGATATTGCTTATAAGCAACAACAATATGAT
GAAGTACAAATCAAACTAAATAACTTGATTAAAACCATCGAGGATAATCCGGACTTAACATCAGTAATCAGACCAAGTAT
TCAAAAATATGAAAAGCAACTCAATGACATTACGAATCAAATCAACCAACTCAAAAATCAACAAAATGAAGATAAGCCTT
TATTTGATGCCAAAGAAATCAGTAAACTATTACAACACATCTTTCATGATATTAAGCACATAGAAAAATCTCGACTCAAA
GCATTGTATCTATCAGTGATTGATCGCATTGATATTAAAAAAGATGGTAATCATAAAAAACAATTCTATGTCACACTCAA
ACTTAATAACGAAATCATAAAACAACTTTTCAATAATAAACAACTCGACGAAGTGCATCTCAGCACTTCGTCTTTGTTTT
TGCCCCAAACACTATATCTTACTATTTAG
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| ccrB | Staphylococcus aureus N315 |
100 |
100 |
1 |