Detailed information NTG1038196

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: V2K10_RS06180
• Genome accession: NZ_CP167067
• Coordinates: 1216293..1217330 (-)
• Length: 345 a.a.
• NCBI ID: WP_002989068.1
• Uniprot ID: Q1JKX2
• Organism: Streptococcus pyogenes strain Isolate 21
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 1211293..1222330

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
V2K10_RS06155 (V2K10_006155)	-	1211297..1211824 (-)	528	WP_002983837.1	Dps family protein	-
V2K10_RS06160 (V2K10_006160)	-	1212052..1212678 (+)	627	WP_002989076.1	A24 family peptidase	-
V2K10_RS06165 (V2K10_006165)	rlmN	1212760..1213839 (-)	1080	WP_002989074.1	23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN	-
V2K10_RS06170 (V2K10_006170)	-	1213843..1214463 (-)	621	WP_032461520.1	YutD family protein	-
V2K10_RS06175 (V2K10_006175)	-	1214911..1215888 (-)	978	WP_002989070.1	LacI family DNA-binding transcriptional regulator	-
V2K10_RS06180 (V2K10_006180)	sepM	1216293..1217330 (-)	1038	WP_002989068.1	SepM family pheromone-processing serine protease	Regulator
V2K10_RS06185 (V2K10_006185)	coaD	1217317..1217808 (-)	492	WP_002983821.1	pantetheine-phosphate adenylyltransferase	-
V2K10_RS06190 (V2K10_006190)	rsmD	1217798..1218337 (-)	540	WP_002983819.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
V2K10_RS06195 (V2K10_006195)	asnA	1218460..1219452 (-)	993	WP_002983817.1	aspartate--ammonia ligase	-
V2K10_RS06200 (V2K10_006200)	arcC	1219766..1220716 (-)	951	WP_002989065.1	carbamate kinase	-
V2K10_RS06205 (V2K10_006205)	-	1220736..1222067 (-)	1332	WP_002989063.1	dipeptidase	-

Sequence

Protein

• Length: 345 a.a.
• Molecular weight: 37527.17 Da
• Isoelectric Point: 9.5788

>NTDB_id=1038196 V2K10_RS06180 WP_002989068.1 1216293..1217330(-) (sepM) [Streptococcus pyogenes strain Isolate 21]
MKRLNKIKWWLVGLLALISLLLALFFPLPYYIEMPGGAYDIRTVLQVNGKEDKRKGAYQFVAVGISRASLAQLLYAWLTP
FTEISTAEDTTGGYSDADFLRINQFYMETSQNAAIYQALSLAGKPVTLDYKGVYVLDVNNESTFKGTLHLADTVTGVNGK
QFTSSAELIDYVSHLKLGDEVTVQFTSDNKPKKGVGRIIKLKNGKNGIGIALTDHTSVNSEDTVIFSTKGVGGPSAGLMF
TLDIYDQITKEDLRKGRTIAGTGTIGKDGEVGDIGGAGLKVVAAAEAGADIFFVPNNPVDKEIKKVNPNAISNYEEAKRA
AKRLKTKMKIVPVTTVQEALVYLRK

Nucleotide

• Length: 1038 bp

>NTDB_id=1038196 V2K10_RS06180 WP_002989068.1 1216293..1217330(-) (sepM) [Streptococcus pyogenes strain Isolate 21]
ATGAAAAGACTTAACAAAATCAAATGGTGGTTAGTGGGTCTGCTAGCTTTAATCTCTTTGTTGCTAGCGTTATTTTTTCC
GCTACCTTATTATATTGAAATGCCTGGAGGCGCTTACGATATTCGGACTGTCTTACAAGTCAATGGCAAAGAAGACAAAC
GAAAAGGAGCTTACCAGTTTGTTGCAGTGGGCATTAGTCGTGCCAGCCTCGCTCAGCTATTATATGCTTGGCTGACACCG
TTTACTGAAATTAGTACAGCAGAAGATACAACAGGCGGATACAGCGATGCTGATTTCCTTCGAATTAATCAATTTTACAT
GGAAACATCACAAAATGCAGCTATTTATCAAGCTTTATCCTTAGCTGGAAAACCAGTTACATTAGATTATAAAGGCGTAT
ATGTTTTAGACGTAAACAACGAATCTACTTTTAAAGGAACGTTACACTTAGCAGATACTGTAACAGGTGTAAATGGTAAA
CAGTTTACTAGTTCAGCAGAACTTATTGACTATGTTTCTCACCTAAAACTAGGGGATGAAGTTACGGTTCAGTTTACGAG
TGATAATAAGCCTAAAAAAGGAGTTGGCCGTATTATCAAACTGAAAAATGGGAAAAATGGGATTGGCATTGCCTTGACTG
ATCATACAAGTGTCAATTCAGAAGACACAGTGATCTTTAGTACTAAAGGAGTAGGAGGACCTAGTGCTGGTCTAATGTTT
ACTCTTGATATATATGATCAAATAACTAAAGAAGATTTACGCAAGGGCCGTACAATTGCAGGTACAGGAACTATTGGCAA
GGATGGCGAAGTAGGAGATATTGGTGGTGCAGGTCTTAAAGTAGTTGCAGCAGCTGAAGCTGGTGCAGATATATTTTTTG
TTCCGAATAATCCTGTTGATAAGGAAATTAAAAAAGTTAATCCAAATGCTATAAGTAATTACGAAGAAGCCAAACGGGCA
GCCAAACGACTAAAGACCAAAATGAAGATTGTTCCTGTTACGACTGTTCAAGAGGCACTGGTTTATCTTCGCAAATAG

Domains

Predicted by InterproScan.

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (233-309)

• PDZ domain (PDZ_2) (129-192)

3D structure

• AlphaFold DB: Q1JKX2

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	68.986	100	0.69