Detailed information NTG1038144

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: ACB345_RS05665
• Genome accession: NZ_CP167025
• Coordinates: 1142238..1143275 (-)
• Length: 345 a.a.
• NCBI ID: WP_010922499.1
• Uniprot ID: A0A4U9I5V9
• Organism: Streptococcus pyogenes strain Isolate
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 1137238..1148275

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ACB345_RS05645 (ACB345_05645)	-	1137980..1138606 (+)	627	WP_002983834.1	A24 family peptidase	-
ACB345_RS05650 (ACB345_05650)	rlmN	1138688..1139767 (-)	1080	WP_031488529.1	23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN	-
ACB345_RS05655 (ACB345_05655)	-	1139771..1140391 (-)	621	WP_002992791.1	YutD family protein	-
ACB345_RS05660 (ACB345_05660)	-	1140839..1141816 (-)	978	WP_031577505.1	LacI family DNA-binding transcriptional regulator	-
ACB345_RS05665 (ACB345_05665)	sepM	1142238..1143275 (-)	1038	WP_010922499.1	SepM family pheromone-processing serine protease	Regulator
ACB345_RS05670 (ACB345_05670)	coaD	1143262..1143753 (-)	492	WP_002983821.1	pantetheine-phosphate adenylyltransferase	-
ACB345_RS05675 (ACB345_05675)	rsmD	1143743..1144282 (-)	540	WP_002983819.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
ACB345_RS05680 (ACB345_05680)	asnA	1144405..1145397 (-)	993	WP_002983817.1	aspartate--ammonia ligase	-
ACB345_RS05685 (ACB345_05685)	arcC	1145710..1146660 (-)	951	WP_010922501.1	carbamate kinase	-
ACB345_RS05690 (ACB345_05690)	-	1146680..1148011 (-)	1332	WP_030126384.1	dipeptidase	-

Sequence

Protein

• Length: 345 a.a.
• Molecular weight: 37541.24 Da
• Isoelectric Point: 9.6692

>NTDB_id=1038144 ACB345_RS05665 WP_010922499.1 1142238..1143275(-) (sepM) [Streptococcus pyogenes strain Isolate]
MKRLKKIKWWLVGLLALISLLLALFFPLPYYIEMPGGAYDIRTVLQVNGKEDKRKGAYQFVAVGISRASLAQLLYAWLTP
FTEISTAEDTTGGYSDADFLRINQFYMETSQNAAIYQALSLAGKPVTLDYKGVYVLDVNNESTFKGTLHLADTVTGVNGK
QFTSSAELIDYVSHLKLGDEVTVQFTSDNKPKKGVGRIIKLKNGKNGIGIALTDHTSVNSEDTVIFSTKGVGGPSAGLMF
TLDIYDQITKEDLRKGRTIAGTGTIGKDGEVGDIGGAGLKVVAAAEAGADIFFVPNNPVDKEIKKVNPNAISNYEEAKRA
AKRLKTKMKIVPVTTVQEALVYLRK

Nucleotide

• Length: 1038 bp

>NTDB_id=1038144 ACB345_RS05665 WP_010922499.1 1142238..1143275(-) (sepM) [Streptococcus pyogenes strain Isolate]
ATGAAAAGACTTAAAAAAATCAAATGGTGGTTAGTGGGTCTGCTAGCTTTAATCTCTTTATTGCTAGCGTTATTTTTTCC
GCTACCTTATTATATTGAAATGCCTGGAGGCGCTTACGATATTCGGACTGTCTTACAAGTCAATGGCAAAGAAGACAAAC
GAAAAGGAGCTTACCAGTTTGTTGCAGTGGGCATTAGTCGTGCCAGCCTCGCGCAGCTATTATATGCTTGGCTGACACCG
TTTACTGAAATTAGTACAGCAGAAGATACAACAGGCGGATACAGCGATGCTGATTTCCTTCGAATTAATCAATTCTACAT
GGAAACATCACAAAATGCAGCTATTTATCAAGCTTTATCCTTAGCTGGAAAACCAGTTACATTAGATTATAAAGGCGTAT
ATGTTTTAGACGTAAACAACGAATCTACTTTTAAAGGAACGTTACACTTAGCAGATACTGTAACAGGTGTAAATGGTAAA
CAGTTTACTAGTTCAGCAGAACTTATTGACTATGTTTCTCACCTAAAACTAGGGGATGAAGTTACGGTTCAGTTTACGAG
TGATAATAAGCCTAAAAAAGGAGTTGGCCGTATTATCAAACTGAAAAATGGGAAAAATGGGATTGGCATTGCCTTGACTG
ATCATACAAGTGTCAATTCAGAAGACACAGTGATCTTTAGTACTAAAGGAGTAGGAGGACCTAGTGCTGGTCTAATGTTT
ACTCTTGATATATATGATCAAATAACTAAAGAAGATTTACGCAAGGGCCGTACAATTGCAGGTACAGGAACTATTGGCAA
GGATGGCGAAGTAGGAGATATTGGTGGTGCAGGTCTTAAAGTAGTTGCAGCAGCTGAAGCTGGTGCAGATATATTTTTTG
TTCCGAATAATCCTGTTGATAAGGAAATTAAAAAAGTTAATCCAAATGCTATAAGTAATTACGAAGAAGCCAAACGGGCA
GCCAAACGACTAAAGACCAAAATGAAGATTGTTCCTGTTACGACTGTTCAAGAGGCACTGGTTTATCTTCGCAAATAA

Domains

Predicted by InterproScan.

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (233-309)

• PDZ domain (PDZ_2) (129-192)

3D structure

• AlphaFold DB: A0A4U9I5V9

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	69.275	100	0.693