Detailed information NTG1038085

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: ACB338_RS06390
• Genome accession: NZ_CP167024
• Coordinates: 1243829..1244866 (-)
• Length: 345 a.a.
• NCBI ID: WP_010922499.1
• Uniprot ID: A0A4U9I5V9
• Organism: Streptococcus pyogenes strain Isolate
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 1238829..1249866

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ACB338_RS06370 (ACB338_06375)	-	1239580..1240206 (+)	627	WP_010922497.1	A24 family peptidase	-
ACB338_RS06375 (ACB338_06380)	rlmN	1240288..1241367 (-)	1080	WP_002992788.1	23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN	-
ACB338_RS06380 (ACB338_06385)	-	1241371..1241991 (-)	621	WP_011285637.1	YutD family protein	-
ACB338_RS06385 (ACB338_06390)	-	1242439..1243415 (-)	977	Protein_1212	LacI family DNA-binding transcriptional regulator	-
ACB338_RS06390 (ACB338_06395)	sepM	1243829..1244866 (-)	1038	WP_010922499.1	SepM family pheromone-processing serine protease	Regulator
ACB338_RS06395 (ACB338_06400)	coaD	1244853..1245344 (-)	492	WP_002983821.1	pantetheine-phosphate adenylyltransferase	-
ACB338_RS06400 (ACB338_06405)	rsmD	1245334..1245873 (-)	540	WP_002983819.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
ACB338_RS06405 (ACB338_06410)	asnA	1245996..1246988 (-)	993	WP_010922500.1	aspartate--ammonia ligase	-
ACB338_RS06410 (ACB338_06415)	arcC	1247301..1248251 (-)	951	WP_010922501.1	carbamate kinase	-
ACB338_RS06415 (ACB338_06420)	-	1248271..1249602 (-)	1332	WP_011285641.1	dipeptidase	-

Sequence

Protein

• Length: 345 a.a.
• Molecular weight: 37541.24 Da
• Isoelectric Point: 9.6692

>NTDB_id=1038085 ACB338_RS06390 WP_010922499.1 1243829..1244866(-) (sepM) [Streptococcus pyogenes strain Isolate]
MKRLKKIKWWLVGLLALISLLLALFFPLPYYIEMPGGAYDIRTVLQVNGKEDKRKGAYQFVAVGISRASLAQLLYAWLTP
FTEISTAEDTTGGYSDADFLRINQFYMETSQNAAIYQALSLAGKPVTLDYKGVYVLDVNNESTFKGTLHLADTVTGVNGK
QFTSSAELIDYVSHLKLGDEVTVQFTSDNKPKKGVGRIIKLKNGKNGIGIALTDHTSVNSEDTVIFSTKGVGGPSAGLMF
TLDIYDQITKEDLRKGRTIAGTGTIGKDGEVGDIGGAGLKVVAAAEAGADIFFVPNNPVDKEIKKVNPNAISNYEEAKRA
AKRLKTKMKIVPVTTVQEALVYLRK

Nucleotide

• Length: 1038 bp

>NTDB_id=1038085 ACB338_RS06390 WP_010922499.1 1243829..1244866(-) (sepM) [Streptococcus pyogenes strain Isolate]
ATGAAAAGACTTAAAAAAATCAAATGGTGGTTAGTGGGTCTGCTAGCTTTAATCTCTTTGTTGCTAGCGTTATTTTTTCC
GCTACCTTATTATATTGAAATGCCTGGAGGCGCTTACGATATTCGGACTGTCTTACAAGTCAATGGCAAAGAAGACAAAC
GAAAAGGAGCTTACCAGTTTGTTGCAGTGGGCATTAGTCGTGCCAGCCTCGCTCAGCTATTATATGCTTGGCTGACACCG
TTTACTGAAATTAGTACAGCAGAAGATACAACAGGCGGATACAGCGATGCTGATTTCCTTCGAATTAATCAATTTTACAT
GGAAACATCACAAAATGCAGCTATTTATCAAGCTTTATCCTTAGCTGGAAAACCAGTTACATTAGATTATAAAGGCGTAT
ATGTTTTAGACGTAAACAACGAATCTACTTTTAAAGGAACGCTACACTTAGCAGATACTGTAACAGGTGTAAATGGTAAA
CAGTTTACTAGTTCAGCAGAACTTATTGACTATGTTTCTCACCTAAAACTAGGGGATGAAGTTACGGTTCAGTTTACGAG
TGATAATAAGCCTAAAAAAGGAGTTGGCCGTATTATCAAACTGAAAAATGGGAAAAATGGGATTGGCATTGCCTTGACTG
ATCATACAAGTGTCAATTCAGAAGACACAGTGATCTTTAGTACTAAAGGAGTAGGAGGACCTAGTGCTGGTCTAATGTTT
ACTCTTGATATATATGATCAAATAACTAAAGAAGATTTACGCAAGGGCCGTACAATTGCAGGTACAGGAACTATTGGCAA
GGATGGCGAAGTAGGAGATATTGGTGGTGCAGGTCTTAAAGTAGTTGCAGCAGCTGAAGCTGGTGCAGATATATTTTTTG
TTCCGAATAATCCTGTTGATAAGGAAATTAAAAAAGTTAATCCAAATGCTATAAGTAATTACGAAGAAGCCAAACGGGCA
GCCAAACGACTAAAGACCAAAATGAAGATTGTTCCTGTTACGACTGTTCAAGAGGCACTGGTTTATCTTCGCAAATAA

Domains

Predicted by InterproScan.

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (233-309)

• PDZ domain (PDZ_2) (129-192)

3D structure

• AlphaFold DB: A0A4U9I5V9

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	69.275	100	0.693