Detailed information NTG1038033

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: ACB339_RS06305
• Genome accession: NZ_CP167023
• Coordinates: 1213791..1214828 (-)
• Length: 345 a.a.
• NCBI ID: WP_010922499.1
• Uniprot ID: A0A4U9I5V9
• Organism: Streptococcus pyogenes strain Isolate 3
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 1208791..1219828

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ACB339_RS06285 (ACB339_06280)	-	1209541..1210167 (+)	627	WP_002989076.1	A24 family peptidase	-
ACB339_RS06290 (ACB339_06285)	rlmN	1210249..1211328 (-)	1080	WP_002992788.1	23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN	-
ACB339_RS06295 (ACB339_06290)	-	1211332..1211952 (-)	621	WP_002992791.1	YutD family protein	-
ACB339_RS06300 (ACB339_06295)	-	1212400..1213377 (-)	978	WP_011054718.1	LacI family DNA-binding transcriptional regulator	-
ACB339_RS06305 (ACB339_06300)	sepM	1213791..1214828 (-)	1038	WP_010922499.1	SepM family pheromone-processing serine protease	Regulator
ACB339_RS06310 (ACB339_06305)	coaD	1214815..1215306 (-)	492	WP_002983821.1	pantetheine-phosphate adenylyltransferase	-
ACB339_RS06315 (ACB339_06310)	rsmD	1215296..1215835 (-)	540	WP_002983819.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
ACB339_RS06320 (ACB339_06315)	asnA	1215958..1216950 (-)	993	WP_002983817.1	aspartate--ammonia ligase	-
ACB339_RS06325 (ACB339_06320)	arcC	1217263..1218213 (-)	951	WP_003051912.1	carbamate kinase	-
ACB339_RS06330 (ACB339_06325)	-	1218233..1219564 (-)	1332	WP_011054719.1	dipeptidase	-

Sequence

Protein

• Length: 345 a.a.
• Molecular weight: 37541.24 Da
• Isoelectric Point: 9.6692

>NTDB_id=1038033 ACB339_RS06305 WP_010922499.1 1213791..1214828(-) (sepM) [Streptococcus pyogenes strain Isolate 3]
MKRLKKIKWWLVGLLALISLLLALFFPLPYYIEMPGGAYDIRTVLQVNGKEDKRKGAYQFVAVGISRASLAQLLYAWLTP
FTEISTAEDTTGGYSDADFLRINQFYMETSQNAAIYQALSLAGKPVTLDYKGVYVLDVNNESTFKGTLHLADTVTGVNGK
QFTSSAELIDYVSHLKLGDEVTVQFTSDNKPKKGVGRIIKLKNGKNGIGIALTDHTSVNSEDTVIFSTKGVGGPSAGLMF
TLDIYDQITKEDLRKGRTIAGTGTIGKDGEVGDIGGAGLKVVAAAEAGADIFFVPNNPVDKEIKKVNPNAISNYEEAKRA
AKRLKTKMKIVPVTTVQEALVYLRK

Nucleotide

• Length: 1038 bp

>NTDB_id=1038033 ACB339_RS06305 WP_010922499.1 1213791..1214828(-) (sepM) [Streptococcus pyogenes strain Isolate 3]
ATGAAAAGACTTAAAAAAATCAAATGGTGGTTAGTGGGTCTGCTAGCTTTAATCTCTTTGTTGCTAGCGTTATTTTTTCC
GCTACCTTATTATATTGAAATGCCTGGAGGCGCTTACGATATTCGGACTGTCTTACAAGTCAATGGCAAAGAAGACAAAC
GAAAAGGAGCTTACCAGTTTGTTGCAGTGGGCATTAGTCGTGCCAGCCTCGCTCAGCTATTATATGCTTGGCTGACACCG
TTTACTGAAATTAGTACAGCAGAAGATACAACAGGCGGATACAGCGATGCTGATTTCCTTCGAATTAATCAATTTTACAT
GGAAACATCACAAAATGCAGCTATTTATCAAGCTTTATCCTTAGCTGGAAAACCAGTTACATTAGATTATAAAGGCGTAT
ATGTTTTAGACGTAAACAACGAATCTACTTTTAAAGGAACGCTACACTTAGCAGATACTGTAACAGGTGTAAATGGTAAA
CAGTTTACTAGTTCAGCAGAACTTATTGACTATGTTTCTCACCTAAAACTAGGGGATGAAGTTACGGTTCAGTTTACGAG
TGATAATAAGCCTAAAAAAGGAGTTGGCCGTATTATCAAACTGAAAAATGGGAAAAATGGGATTGGCATTGCCTTGACTG
ATCATACAAGTGTCAATTCAGAAGACACAGTGATCTTTAGTACTAAAGGAGTAGGAGGACCTAGTGCTGGTCTAATGTTT
ACTCTTGATATATATGATCAAATAACTAAAGAAGATTTACGCAAGGGCCGTACAATTGCAGGTACAGGAACTATTGGCAA
GGATGGCGAAGTAGGAGATATTGGTGGTGCAGGTCTTAAAGTAGTTGCAGCAGCTGAAGCTGGTGCAGATATATTTTTTG
TTCCGAATAATCCTGTTGATAAGGAAATTAAAAAAGTTAATCCAAATGCTATAAGTAATTACGAAGAAGCCAAACGGGCA
GCCAAACGACTAAAGACCAAAATGAAGATTGTTCCTGTTACGACTGTTCAAGAGGCACTGGTTTATCTTCGCAAATAA

Domains

Predicted by InterproScan.

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (233-309)

• PDZ domain (PDZ_2) (129-192)

3D structure

• AlphaFold DB: A0A4U9I5V9

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	69.275	100	0.693