Detailed information NTG1037978

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: ACB335_RS06150
• Genome accession: NZ_CP167022
• Coordinates: 1212850..1213887 (-)
• Length: 345 a.a.
• NCBI ID: WP_010922499.1
• Uniprot ID: A0A4U9I5V9
• Organism: Streptococcus pyogenes strain Isolate 4
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 1207850..1218887

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ACB335_RS06130 (ACB335_06130)	-	1208592..1209218 (+)	627	WP_002983834.1	A24 family peptidase	-
ACB335_RS06135 (ACB335_06135)	rlmN	1209300..1210379 (-)	1080	WP_031488529.1	23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN	-
ACB335_RS06140 (ACB335_06140)	-	1210383..1211003 (-)	621	WP_002992791.1	YutD family protein	-
ACB335_RS06145 (ACB335_06145)	-	1211451..1212428 (-)	978	WP_031577505.1	LacI family DNA-binding transcriptional regulator	-
ACB335_RS06150 (ACB335_06150)	sepM	1212850..1213887 (-)	1038	WP_010922499.1	SepM family pheromone-processing serine protease	Regulator
ACB335_RS06155 (ACB335_06155)	coaD	1213874..1214365 (-)	492	WP_002983821.1	pantetheine-phosphate adenylyltransferase	-
ACB335_RS06160 (ACB335_06160)	rsmD	1214355..1214894 (-)	540	WP_002983819.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
ACB335_RS06165 (ACB335_06165)	asnA	1215017..1216009 (-)	993	WP_002983817.1	aspartate--ammonia ligase	-
ACB335_RS06170 (ACB335_06170)	arcC	1216322..1217272 (-)	951	WP_010922501.1	carbamate kinase	-
ACB335_RS06175 (ACB335_06175)	-	1217292..1218623 (-)	1332	WP_030126384.1	dipeptidase	-

Sequence

Protein

• Length: 345 a.a.
• Molecular weight: 37541.24 Da
• Isoelectric Point: 9.6692

>NTDB_id=1037978 ACB335_RS06150 WP_010922499.1 1212850..1213887(-) (sepM) [Streptococcus pyogenes strain Isolate 4]
MKRLKKIKWWLVGLLALISLLLALFFPLPYYIEMPGGAYDIRTVLQVNGKEDKRKGAYQFVAVGISRASLAQLLYAWLTP
FTEISTAEDTTGGYSDADFLRINQFYMETSQNAAIYQALSLAGKPVTLDYKGVYVLDVNNESTFKGTLHLADTVTGVNGK
QFTSSAELIDYVSHLKLGDEVTVQFTSDNKPKKGVGRIIKLKNGKNGIGIALTDHTSVNSEDTVIFSTKGVGGPSAGLMF
TLDIYDQITKEDLRKGRTIAGTGTIGKDGEVGDIGGAGLKVVAAAEAGADIFFVPNNPVDKEIKKVNPNAISNYEEAKRA
AKRLKTKMKIVPVTTVQEALVYLRK

Nucleotide

• Length: 1038 bp

>NTDB_id=1037978 ACB335_RS06150 WP_010922499.1 1212850..1213887(-) (sepM) [Streptococcus pyogenes strain Isolate 4]
ATGAAAAGACTTAAAAAAATCAAATGGTGGTTAGTGGGTCTGCTAGCTTTAATCTCTTTATTGCTAGCGTTATTTTTTCC
GCTACCTTATTATATTGAAATGCCTGGAGGCGCTTACGATATTCGGACTGTCTTACAAGTCAATGGCAAAGAAGACAAAC
GAAAAGGAGCTTACCAGTTTGTTGCAGTGGGCATTAGTCGTGCCAGCCTCGCGCAGCTATTATATGCTTGGCTGACACCG
TTTACTGAAATTAGTACAGCAGAAGATACAACAGGCGGATACAGCGATGCTGATTTCCTTCGAATTAATCAATTCTACAT
GGAAACATCACAAAATGCAGCTATTTATCAAGCTTTATCCTTAGCTGGAAAACCAGTTACATTAGATTATAAAGGCGTAT
ATGTTTTAGACGTAAACAACGAATCTACTTTTAAAGGAACGTTACACTTAGCAGATACTGTAACAGGTGTAAATGGTAAA
CAGTTTACTAGTTCAGCAGAACTTATTGACTATGTTTCTCACCTAAAACTAGGGGATGAAGTTACGGTTCAGTTTACGAG
TGATAATAAGCCTAAAAAAGGAGTTGGCCGTATTATCAAACTGAAAAATGGGAAAAATGGGATTGGCATTGCCTTGACTG
ATCATACAAGTGTCAATTCAGAAGACACAGTGATCTTTAGTACTAAAGGAGTAGGAGGACCTAGTGCTGGTCTAATGTTT
ACTCTTGATATATATGATCAAATAACTAAAGAAGATTTACGCAAGGGCCGTACAATTGCAGGTACAGGAACTATTGGCAA
GGATGGCGAAGTAGGAGATATTGGTGGTGCAGGTCTTAAAGTAGTTGCAGCAGCTGAAGCTGGTGCAGATATATTTTTTG
TTCCGAATAATCCTGTTGATAAGGAAATTAAAAAAGTTAATCCAAATGCTATAAGTAATTACGAAGAAGCCAAACGGGCA
GCCAAACGACTAAAGACCAAAATGAAGATTGTTCCTGTTACGACTGTTCAAGAGGCACTGGTTTATCTTCGCAAATAA

Domains

Predicted by InterproScan.

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (233-309)

• PDZ domain (PDZ_2) (129-192)

3D structure

• AlphaFold DB: A0A4U9I5V9

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	69.275	100	0.693