Detailed information NTG1037912

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: ACB363_RS03215
• Genome accession: NZ_CP167021
• Coordinates: 616308..617345 (+)
• Length: 345 a.a.
• NCBI ID: WP_002983824.1
• Uniprot ID: A0A4U9C0Q7
• Organism: Streptococcus pyogenes strain Isolate 5
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 611308..622345

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ACB363_RS03190 (ACB363_03190)	-	611572..612903 (+)	1332	WP_011054719.1	dipeptidase	-
ACB363_RS03195 (ACB363_03195)	arcC	612923..613873 (+)	951	WP_011528820.1	carbamate kinase	-
ACB363_RS03200 (ACB363_03200)	asnA	614186..615178 (+)	993	WP_002983817.1	aspartate--ammonia ligase	-
ACB363_RS03205 (ACB363_03205)	rsmD	615301..615840 (+)	540	WP_002983819.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
ACB363_RS03210 (ACB363_03210)	coaD	615830..616321 (+)	492	WP_002983821.1	pantetheine-phosphate adenylyltransferase	-
ACB363_RS03215 (ACB363_03215)	sepM	616308..617345 (+)	1038	WP_002983824.1	SepM family pheromone-processing serine protease	Regulator
ACB363_RS03220 (ACB363_03220)	-	617759..618736 (+)	978	WP_002994809.1	LacI family DNA-binding transcriptional regulator	-
ACB363_RS03225 (ACB363_03225)	-	619184..619804 (+)	621	WP_002992791.1	YutD family protein	-
ACB363_RS03230 (ACB363_03230)	rlmN	619808..620887 (+)	1080	WP_002992788.1	23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN	-
ACB363_RS03235 (ACB363_03235)	-	620969..621596 (-)	628	Protein_587	prepilin peptidase	-

Sequence

Protein

• Length: 345 a.a.
• Molecular weight: 37555.27 Da
• Isoelectric Point: 9.6692

>NTDB_id=1037912 ACB363_RS03215 WP_002983824.1 616308..617345(+) (sepM) [Streptococcus pyogenes strain Isolate 5]
MKRLKKIKWWLVGLLALISLLLALFFPLPYYIEMPGGAYDIRTVLQVNGKEDKRKGAYQFVAVGISRASLAQLLYAWLTP
FTEISTAEDTTGGYSDADFLRINQFYMETSQNAAIYQALSLAGKPVTLDYKGVYVLDVNNESTFKGTLHLADTVTGVNGK
QFTSSAELIDYVSHLKLGDEVTIQFTSDNKPKKGVGRIIKLKNGKNGIGIALTDHTSVNSEDTVIFSTKGVGGPSAGLMF
TLDIYDQITKEDLRKGRTIAGTGTIGKDGEVGDIGGAGLKVVAAAEAGADIFFVPNNPVDKEIKKVNPNAISNYEEAKRA
AKRLKTKMKIVPVTTVQEALVYLRK

Nucleotide

• Length: 1038 bp

>NTDB_id=1037912 ACB363_RS03215 WP_002983824.1 616308..617345(+) (sepM) [Streptococcus pyogenes strain Isolate 5]
ATGAAAAGACTTAAAAAAATCAAATGGTGGTTAGTGGGTCTGCTAGCTTTAATCTCTTTGTTGCTAGCGTTATTTTTTCC
GCTACCTTATTATATTGAAATGCCTGGAGGCGCTTACGATATTCGGACTGTCTTACAAGTCAATGGCAAAGAAGACAAAC
GAAAAGGAGCTTACCAGTTTGTTGCAGTGGGCATTAGTCGTGCCAGCCTCGCTCAGCTATTATATGCTTGGCTGACACCG
TTTACTGAAATTAGTACAGCAGAAGATACAACAGGCGGATACAGCGATGCTGATTTCCTTCGAATTAATCAATTTTACAT
GGAAACATCACAAAATGCAGCTATTTATCAAGCTTTATCCTTAGCTGGAAAACCAGTTACATTAGATTATAAAGGCGTAT
ATGTTTTAGACGTAAACAACGAATCTACTTTTAAAGGAACGTTACACTTAGCAGATACTGTAACAGGTGTAAATGGTAAA
CAGTTTACTAGTTCAGCAGAACTTATTGACTATGTTTCTCACCTAAAACTAGGGGATGAAGTTACGATTCAGTTTACGAG
TGATAATAAGCCTAAAAAAGGAGTTGGCCGTATTATCAAACTGAAAAATGGGAAAAATGGGATTGGCATTGCCTTGACTG
ATCATACAAGTGTCAATTCAGAAGACACAGTGATCTTTAGTACTAAAGGAGTAGGAGGACCTAGTGCTGGTCTAATGTTT
ACTCTTGATATATATGATCAAATAACTAAAGAAGATTTACGCAAGGGCCGTACAATTGCAGGTACAGGAACTATTGGCAA
GGATGGCGAAGTAGGAGATATTGGTGGTGCAGGTCTTAAAGTAGTTGCAGCAGCTGAAGCTGGTGCAGATATATTTTTTG
TTCCGAATAATCCTGTTGATAAGGAAATTAAAAAAGTTAATCCAAATGCTATAAGTAATTACGAAGAAGCCAAACGGGCA
GCCAAACGACTAAAGACCAAAATGAAGATTGTTCCTGTTACGACTGTTCAAGAGGCACTGGTTTATCTTCGCAAATAA

Domains

Predicted by InterproScan.

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (233-309)

• PDZ domain (PDZ_2) (129-192)

3D structure

• AlphaFold DB: A0A4U9C0Q7

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	68.986	100	0.69