Detailed information NTG1037650

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: ACB332_RS05905
• Genome accession: NZ_CP167016
• Coordinates: 1179087..1180124 (-)
• Length: 345 a.a.
• NCBI ID: WP_010922499.1
• Uniprot ID: A0A4U9I5V9
• Organism: Streptococcus pyogenes strain Isolate 10
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 1174087..1185124

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ACB332_RS05885 (ACB332_05885)	-	1174837..1175463 (+)	627	WP_002983834.1	A24 family peptidase	-
ACB332_RS05890 (ACB332_05890)	rlmN	1175545..1176624 (-)	1080	WP_020905325.1	23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN	-
ACB332_RS05895 (ACB332_05895)	-	1176628..1177248 (-)	621	WP_002992791.1	YutD family protein	-
ACB332_RS05900 (ACB332_05900)	-	1177696..1178673 (-)	978	WP_002994809.1	LacI family DNA-binding transcriptional regulator	-
ACB332_RS05905 (ACB332_05905)	sepM	1179087..1180124 (-)	1038	WP_010922499.1	SepM family pheromone-processing serine protease	Regulator
ACB332_RS05910 (ACB332_05910)	coaD	1180111..1180602 (-)	492	WP_002983821.1	pantetheine-phosphate adenylyltransferase	-
ACB332_RS05915 (ACB332_05915)	rsmD	1180592..1181131 (-)	540	WP_002983819.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
ACB332_RS05920 (ACB332_05920)	asnA	1181254..1182246 (-)	993	WP_020905328.1	aspartate--ammonia ligase	-
ACB332_RS05925 (ACB332_05925)	arcC	1182559..1183509 (-)	951	WP_010922501.1	carbamate kinase	-
ACB332_RS05930 (ACB332_05930)	-	1183529..1184860 (-)	1332	WP_011054719.1	dipeptidase	-

Sequence

Protein

• Length: 345 a.a.
• Molecular weight: 37541.24 Da
• Isoelectric Point: 9.6692

>NTDB_id=1037650 ACB332_RS05905 WP_010922499.1 1179087..1180124(-) (sepM) [Streptococcus pyogenes strain Isolate 10]
MKRLKKIKWWLVGLLALISLLLALFFPLPYYIEMPGGAYDIRTVLQVNGKEDKRKGAYQFVAVGISRASLAQLLYAWLTP
FTEISTAEDTTGGYSDADFLRINQFYMETSQNAAIYQALSLAGKPVTLDYKGVYVLDVNNESTFKGTLHLADTVTGVNGK
QFTSSAELIDYVSHLKLGDEVTVQFTSDNKPKKGVGRIIKLKNGKNGIGIALTDHTSVNSEDTVIFSTKGVGGPSAGLMF
TLDIYDQITKEDLRKGRTIAGTGTIGKDGEVGDIGGAGLKVVAAAEAGADIFFVPNNPVDKEIKKVNPNAISNYEEAKRA
AKRLKTKMKIVPVTTVQEALVYLRK

Nucleotide

• Length: 1038 bp

>NTDB_id=1037650 ACB332_RS05905 WP_010922499.1 1179087..1180124(-) (sepM) [Streptococcus pyogenes strain Isolate 10]
ATGAAAAGACTTAAAAAAATCAAATGGTGGTTAGTGGGTCTGCTAGCTTTAATCTCTTTGTTGCTAGCGTTATTTTTTCC
GCTACCTTATTATATTGAAATGCCTGGAGGCGCTTACGATATTCGGACTGTCTTACAAGTCAATGGCAAAGAAGACAAAC
GAAAAGGAGCTTACCAGTTTGTTGCAGTGGGCATTAGTCGTGCCAGCCTCGCTCAGCTATTATATGCTTGGCTGACACCG
TTTACTGAAATTAGTACAGCAGAAGATACAACAGGCGGATACAGCGATGCTGATTTCCTTCGAATTAATCAATTTTACAT
GGAAACATCACAAAATGCAGCTATTTATCAAGCTTTATCCTTAGCTGGAAAACCAGTTACATTAGATTATAAAGGCGTAT
ATGTTTTAGATGTAAACAACGAATCTACTTTTAAAGGAACGTTACACTTAGCAGATACTGTAACAGGTGTAAATGGTAAA
CAGTTTACTAGTTCAGCAGAACTTATTGACTATGTTTCTCACCTAAAACTAGGGGATGAAGTTACGGTTCAGTTTACGAG
TGATAATAAGCCTAAAAAAGGAGTTGGCCGTATTATCAAACTGAAAAATGGGAAAAATGGGATTGGCATTGCCTTGACTG
ATCATACAAGTGTCAATTCAGAAGACACAGTGATCTTTAGTACTAAAGGAGTAGGAGGACCTAGTGCTGGTCTAATGTTT
ACTCTTGATATATATGATCAAATAACTAAAGAAGATTTACGCAAGGGCCGTACAATTGCAGGTACAGGAACTATTGGCAA
GGATGGCGAAGTAGGAGATATTGGTGGTGCAGGTCTTAAAGTAGTTGCAGCAGCTGAAGCTGGTGCAGATATATTTTTTG
TTCCGAATAATCCTGTTGATAAGGAAATTAAAAAAGTTAATCCAAATGCTATAAGTAATTACGAAGAAGCCAAACGGGCA
GCCAAACGACTAAAGACCAAAATGAAGATTGTTCCTGTTACGACTGTTCAAGAGGCACTGGTTTATCTTCGCAAATAA

Domains

Predicted by InterproScan.

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (233-309)

• PDZ domain (PDZ_2) (129-192)

3D structure

• AlphaFold DB: A0A4U9I5V9

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	69.275	100	0.693