Detailed information NTG1037641

Bioinformatically predicted

Overview

• Name: clpX
• Type: Regulator
• Locus tag: ACB332_RS03460
• Genome accession: NZ_CP167016
• Coordinates: 677492..678721 (+)
• Length: 409 a.a.
• NCBI ID: WP_011888976.1
• Uniprot ID: A2RF17
• Organism: Streptococcus pyogenes strain Isolate 10
• Function: require for competence development (predicted from homology) Competence regulation

Genomic Context

Location: 672492..683721

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ACB332_RS03440 (ACB332_03440)	-	673108..674385 (-)	1278	WP_085634256.1	hydroxymethylglutaryl-CoA reductase, degradative	-
ACB332_RS03445 (ACB332_03445)	-	674372..675547 (-)	1176	WP_129322653.1	hydroxymethylglutaryl-CoA synthase	-
ACB332_RS03450 (ACB332_03450)	-	675756..676595 (+)	840	WP_129322654.1	thymidylate synthase	-
ACB332_RS03455 (ACB332_03455)	-	676675..677172 (+)	498	WP_002984955.1	dihydrofolate reductase	-
ACB332_RS03460 (ACB332_03460)	clpX	677492..678721 (+)	1230	WP_011888976.1	ATP-dependent Clp protease ATP-binding subunit ClpX	Regulator
ACB332_RS03465 (ACB332_03465)	yihA	678731..679330 (+)	600	WP_076639697.1	ribosome biogenesis GTP-binding protein YihA/YsxC	-
ACB332_RS03470 (ACB332_03470)	-	679478..680221 (+)	744	WP_002984942.1	hypothetical protein	-
ACB332_RS03475 (ACB332_03475)	-	680279..682378 (-)	2100	WP_076639696.1	AAA family ATPase	-
ACB332_RS03480 (ACB332_03480)	rpiA	682756..683439 (+)	684	WP_002984936.1	ribose-5-phosphate isomerase RpiA	-

Sequence

Protein

• Length: 409 a.a.
• Molecular weight: 45006.50 Da
• Isoelectric Point: 4.6184

>NTDB_id=1037641 ACB332_RS03460 WP_011888976.1 677492..678721(+) (clpX) [Streptococcus pyogenes strain Isolate 10]
MAGSRTNDIKVYCSFCGKSQDDVKKIIAGNNVFICNECVALSQEIIKEELAEEVLADLTEVPKPKELLDVLNQYVVGQDR
AKRALSVAVYNHYKRVSFTESRDDDDVDLQKSNILMIGPTGSGKTFLAQTLAKSLNVPFAIADATSLTEAGYVGEDVENI
LLKLIQAADYNVERAERGIIYVDEIDKIAKKGENVSITRDVSGEGVQQALLKIIEGTVASVPPQGGRKHPNQEMIQIDTK
NILFIVGGAFDGIEEIVKQRLGEKVIGFGQNSRKIDDNASYMQEIISEDIQKFGLIPEFIGRLPVVAALEQLNTSDLIRI
LTEPRNALVKQYQALLSYDGVELEFDKAALEAIATKAIERKTGARGLRSIIEETMLDIMFEIPSQEDVTKVRITKAAVEG
KSKPVLETA

Nucleotide

• Length: 1230 bp

>NTDB_id=1037641 ACB332_RS03460 WP_011888976.1 677492..678721(+) (clpX) [Streptococcus pyogenes strain Isolate 10]
ATGGCAGGAAGTAGAACTAACGATATTAAAGTATACTGTTCATTTTGTGGTAAAAGCCAGGATGACGTTAAAAAAATTAT
CGCAGGAAATAATGTTTTCATCTGCAATGAATGCGTAGCTTTATCACAAGAAATTATAAAAGAAGAATTGGCTGAAGAAG
TCCTTGCCGATTTGACAGAAGTTCCAAAACCAAAAGAGCTCCTTGATGTTTTAAATCAATATGTGGTTGGTCAAGATCGT
GCTAAACGTGCTTTATCAGTTGCTGTGTACAATCATTATAAGCGTGTCTCGTTTACAGAAAGTCGTGATGACGATGATGT
GGATTTACAAAAGTCTAACATTTTGATGATTGGACCAACAGGTTCAGGAAAAACCTTCTTAGCTCAAACTCTGGCTAAAA
GCCTCAATGTACCATTTGCTATTGCAGATGCAACTTCTTTGACTGAAGCAGGGTATGTTGGAGAAGATGTGGAAAATATT
TTACTCAAACTGATTCAGGCTGCTGACTATAATGTCGAACGAGCAGAGCGTGGTATTATTTATGTTGATGAAATAGATAA
GATTGCTAAAAAAGGTGAGAACGTATCTATCACACGTGATGTATCTGGTGAAGGTGTACAGCAAGCCCTTCTTAAAATTA
TTGAAGGTACGGTAGCAAGTGTTCCCCCACAAGGTGGGCGGAAGCACCCTAATCAAGAAATGATCCAAATTGATACAAAA
AATATCTTGTTTATTGTTGGCGGGGCTTTTGATGGCATCGAGGAGATTGTTAAACAACGTTTAGGTGAAAAAGTTATTGG
TTTTGGTCAAAACAGCCGTAAAATTGATGACAATGCTTCTTATATGCAAGAAATTATTTCAGAAGATATTCAAAAGTTTG
GGCTTATTCCAGAATTTATTGGCCGCTTACCAGTTGTGGCAGCCCTTGAACAACTAAACACATCAGATTTGATTCGAATC
TTAACAGAGCCAAGGAATGCTCTTGTCAAGCAATATCAGGCCCTTCTTTCCTATGATGGGGTTGAATTAGAATTTGATAA
AGCAGCTCTTGAAGCTATCGCAACTAAAGCCATTGAACGTAAGACAGGAGCACGTGGTCTTCGTTCTATTATCGAAGAAA
CGATGCTTGACATCATGTTTGAAATTCCAAGCCAAGAAGATGTCACAAAAGTGCGTATCACCAAGGCTGCTGTCGAAGGC
AAGTCAAAACCCGTTTTAGAGACAGCTTAA

Domains

Predicted by InterproScan.

• AAA domain (Cdc48 subfamily) (AAA_2) (110-305)

• ClpX C4-type zinc finger (zf-C4_ClpX) (12-48)

• C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small) (312-391)

3D structure

• AlphaFold DB: A2RF17

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
clpX	Streptococcus mutans UA159	88.998	100	0.89
clpX	Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819	58.853	98.044	0.577