Detailed information
Bioinformatically predicted
Overview
| Name | pepF | Type | Regulator |
| Locus tag | ACB351_RS05725 | Genome accession | NZ_CP167015 |
| Coordinates | 1135596..1137401 (-) | Length | 601 a.a. |
| NCBI ID | WP_011054652.1 | Uniprot ID | - |
| Organism | Streptococcus pyogenes strain Isolate 11 | ||
| Function | degradation of XIP; competence shut-off (predicted from homology) Competence regulation |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| ICE | 1115353..1162400 | 1135596..1137401 | within | 0 |
Gene organization within MGE regions
Location: 1115353..1162400
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| ACB351_RS05645 (ACB351_05645) | - | 1115391..1116665 (-) | 1275 | WP_011284930.1 | polysaccharide deacetylase family protein | - |
| ACB351_RS05650 (ACB351_05650) | - | 1116760..1118187 (-) | 1428 | WP_011284931.1 | NADP-dependent glyceraldehyde-3-phosphate dehydrogenase | - |
| ACB351_RS05655 (ACB351_05655) | ptsP | 1118372..1120105 (-) | 1734 | WP_002984033.1 | phosphoenolpyruvate--protein phosphotransferase | - |
| ACB351_RS05660 (ACB351_05660) | - | 1120110..1120373 (-) | 264 | WP_002984031.1 | phosphocarrier protein HPr | - |
| ACB351_RS05665 (ACB351_05665) | - | 1120766..1120984 (+) | 219 | WP_002989242.1 | redoxin NrdH | - |
| ACB351_RS05670 (ACB351_05670) | nrdE | 1121004..1123163 (+) | 2160 | WP_002993430.1 | class 1b ribonucleoside-diphosphate reductase subunit alpha | - |
| ACB351_RS05675 (ACB351_05675) | nrdF | 1123496..1124455 (+) | 960 | WP_011017933.1 | class 1b ribonucleoside-diphosphate reductase subunit beta | - |
| ACB351_RS05680 (ACB351_05680) | - | 1124517..1125734 (+) | 1218 | WP_371399988.1 | chloride channel protein | - |
| ACB351_RS05685 (ACB351_05685) | - | 1125830..1126986 (+) | 1157 | Protein_1074 | IS3 family transposase | - |
| ACB351_RS05690 (ACB351_05690) | - | 1127080..1127775 (-) | 696 | WP_002989227.1 | CPBP family intramembrane glutamic endopeptidase | - |
| ACB351_RS05695 (ACB351_05695) | - | 1127794..1128555 (-) | 762 | WP_002995753.1 | DUF3169 family protein | - |
| ACB351_RS05700 (ACB351_05700) | - | 1128552..1128767 (-) | 216 | WP_002989220.1 | helix-turn-helix transcriptional regulator | - |
| ACB351_RS05705 (ACB351_05705) | alaS | 1129128..1131746 (-) | 2619 | WP_011284933.1 | alanine--tRNA ligase | - |
| ACB351_RS05710 (ACB351_05710) | prsA | 1132133..1133188 (-) | 1056 | WP_002984003.1 | peptidylprolyl isomerase PrsA | - |
| ACB351_RS05715 (ACB351_05715) | - | 1133251..1133958 (-) | 708 | WP_011284934.1 | O-methyltransferase | - |
| ACB351_RS05720 (ACB351_05720) | - | 1134024..1135220 (-) | 1197 | WP_002995765.1 | OFA family MFS transporter | - |
| ACB351_RS05725 (ACB351_05725) | pepF | 1135596..1137401 (-) | 1806 | WP_011054652.1 | oligoendopeptidase F | Regulator |
| ACB351_RS05730 (ACB351_05730) | - | 1137414..1138376 (-) | 963 | WP_002995771.1 | competence protein CoiA | - |
| ACB351_RS05735 (ACB351_05735) | - | 1138671..1139387 (-) | 717 | WP_002989197.1 | pseudouridine synthase | - |
| ACB351_RS05740 (ACB351_05740) | nagB | 1139506..1140210 (-) | 705 | WP_021340997.1 | glucosamine-6-phosphate deaminase | - |
| ACB351_RS05745 (ACB351_05745) | queA | 1140412..1141440 (+) | 1029 | WP_011284937.1 | tRNA preQ1(34) S-adenosylmethionine ribosyltransferase-isomerase QueA | - |
| ACB351_RS05750 (ACB351_05750) | - | 1141447..1142667 (+) | 1221 | WP_002989189.1 | DUF3114 domain-containing protein | - |
| ACB351_RS05755 (ACB351_05755) | - | 1142781..1143371 (-) | 591 | WP_002989185.1 | serine hydrolase | - |
| ACB351_RS05760 (ACB351_05760) | - | 1143368..1143616 (-) | 249 | WP_002989183.1 | serine hydrolase | - |
| ACB351_RS05765 (ACB351_05765) | - | 1143672..1143827 (-) | 156 | WP_002989180.1 | hypothetical protein | - |
| ACB351_RS05770 (ACB351_05770) | sodA | 1143994..1144599 (-) | 606 | WP_002983977.1 | superoxide dismutase SodA | - |
| ACB351_RS05775 (ACB351_05775) | holA | 1144696..1145736 (-) | 1041 | WP_002989176.1 | DNA polymerase III subunit delta | - |
| ACB351_RS05780 (ACB351_05780) | - | 1145807..1148049 (-) | 2243 | Protein_1093 | DNA internalization-related competence protein ComEC/Rec2 | - |
| ACB351_RS05785 (ACB351_05785) | - | 1148030..1148692 (-) | 663 | WP_002983967.1 | ComEA family DNA-binding protein | - |
| ACB351_RS05790 (ACB351_05790) | - | 1148892..1149632 (-) | 741 | WP_021340996.1 | 1-acyl-sn-glycerol-3-phosphate acyltransferase | - |
| ACB351_RS05795 (ACB351_05795) | - | 1149750..1150526 (+) | 777 | WP_010922438.1 | tRNA1(Val) (adenine(37)-N6)-methyltransferase | - |
| ACB351_RS05800 (ACB351_05800) | - | 1150516..1150794 (+) | 279 | WP_011017953.1 | GIY-YIG nuclease family protein | - |
| ACB351_RS05805 (ACB351_05805) | - | 1150818..1152818 (-) | 2001 | WP_011284942.1 | potassium transporter Kup | - |
| ACB351_RS05810 (ACB351_05810) | - | 1152945..1154564 (-) | 1620 | WP_002989158.1 | DEAD/DEAH box helicase | - |
| ACB351_RS05815 (ACB351_05815) | - | 1154871..1156415 (-) | 1545 | WP_011284943.1 | peptide chain release factor 3 | - |
| ACB351_RS05820 (ACB351_05820) | - | 1156663..1157358 (-) | 696 | WP_011017956.1 | TIGR02206 family membrane protein | - |
| ACB351_RS05825 (ACB351_05825) | murF | 1157438..1158829 (-) | 1392 | WP_010922441.1 | UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase | - |
| ACB351_RS05830 (ACB351_05830) | - | 1159028..1160074 (-) | 1047 | WP_002989146.1 | D-alanine--D-alanine ligase | - |
| ACB351_RS05835 (ACB351_05835) | recR | 1160175..1160771 (-) | 597 | WP_002983939.1 | recombination mediator RecR | - |
| ACB351_RS05840 (ACB351_05840) | - | 1160818..1161009 (-) | 192 | WP_002983936.1 | hypothetical protein | - |
| ACB351_RS05845 (ACB351_05845) | - | 1161569..1162348 (-) | 780 | WP_014407680.1 | formate/nitrite transporter family protein | - |
Sequence
Protein
Download Length: 601 a.a. Molecular weight: 69341.19 Da Isoelectric Point: 4.7093
>NTDB_id=1037589 ACB351_RS05725 WP_011054652.1 1135596..1137401(-) (pepF) [Streptococcus pyogenes strain Isolate 11]
MTDNRSHLEEKYTWDLSTIFATDKDWEAEVSDLATEIDAAKDFSGHLLDSSANLLTITDTYLELARRVEKVYVYAHMKND
QDTTVAKYQEYQAKASGLYAKFSEVFSFYDPEVMALSQEDYQAFLAETPDLKRYHHFFDKLFQTRDHVLSQAEEELLAGA
QEIFNGAEETFSILDNADIVFPVVKNDKGEDVELTHGNFISLMESKDRSIRQAAYEAMYSTYEQFQHTYAKTLQTNVKVQ
NYKARVHKYDSARQAAMAANFIPEAVYDTLLETVNKHLPLLHRYLKLRQEVLGLDDLKMYDVYTPLSETDLAIGYDEALE
KAEKVLAVFGKDYADRVHRAFTERWIDVHVNKGKRSGAYSGGSYDTNAFMLLNWQDTLDNLYTLVHETGHSLHSTFTRET
QPYVYGDYSIFLAEIASTTNENIMTEALLNEVQDEKERFAILNHYLDGFRGTVFRQTQFAEFEHAIHQADQKGEVLTSEY
LNQLYADLNEKYYGLSKKDNHFIQYEWARIPHFYYNYYVYQYATGFAAASYLADKIVHGTQDDIDHYLAYLKSGNSDYPL
EVIAKAGVDMAKGDYLEAAFKVFDERLTELEVLVSKGIHKS
MTDNRSHLEEKYTWDLSTIFATDKDWEAEVSDLATEIDAAKDFSGHLLDSSANLLTITDTYLELARRVEKVYVYAHMKND
QDTTVAKYQEYQAKASGLYAKFSEVFSFYDPEVMALSQEDYQAFLAETPDLKRYHHFFDKLFQTRDHVLSQAEEELLAGA
QEIFNGAEETFSILDNADIVFPVVKNDKGEDVELTHGNFISLMESKDRSIRQAAYEAMYSTYEQFQHTYAKTLQTNVKVQ
NYKARVHKYDSARQAAMAANFIPEAVYDTLLETVNKHLPLLHRYLKLRQEVLGLDDLKMYDVYTPLSETDLAIGYDEALE
KAEKVLAVFGKDYADRVHRAFTERWIDVHVNKGKRSGAYSGGSYDTNAFMLLNWQDTLDNLYTLVHETGHSLHSTFTRET
QPYVYGDYSIFLAEIASTTNENIMTEALLNEVQDEKERFAILNHYLDGFRGTVFRQTQFAEFEHAIHQADQKGEVLTSEY
LNQLYADLNEKYYGLSKKDNHFIQYEWARIPHFYYNYYVYQYATGFAAASYLADKIVHGTQDDIDHYLAYLKSGNSDYPL
EVIAKAGVDMAKGDYLEAAFKVFDERLTELEVLVSKGIHKS
Nucleotide
Download Length: 1806 bp
>NTDB_id=1037589 ACB351_RS05725 WP_011054652.1 1135596..1137401(-) (pepF) [Streptococcus pyogenes strain Isolate 11]
ATGACTGATAATCGCAGCCATTTAGAAGAAAAATACACTTGGGATTTGAGCACTATTTTTGCAACAGATAAGGATTGGGA
AGCTGAAGTCAGTGACTTAGCTACTGAAATTGACGCGGCTAAGGATTTTTCAGGTCATTTACTAGATTCTAGCGCTAATC
TGTTGACAATTACAGATACTTATTTAGAGTTAGCTCGTCGTGTTGAGAAAGTCTATGTTTATGCTCACATGAAAAATGAC
CAAGACACTACTGTTGCCAAGTATCAAGAATACCAAGCTAAGGCTTCAGGCTTGTATGCAAAGTTTAGCGAAGTGTTTTC
ATTCTATGACCCAGAAGTTATGGCATTGAGTCAGGAAGATTACCAAGCTTTTCTTGCGGAAACACCTGATTTAAAAAGGT
ATCATCATTTCTTTGACAAATTGTTCCAGACACGTGACCATGTGCTCAGCCAGGCTGAAGAGGAATTATTAGCAGGAGCC
CAAGAAATTTTCAACGGCGCTGAAGAAACCTTTAGTATTCTTGATAACGCTGATATTGTCTTTCCAGTAGTTAAAAATGA
TAAGGGGGAAGATGTTGAATTAACCCATGGTAACTTCATTAGCCTAATGGAATCTAAGGACCGTAGCATTCGCCAAGCTG
CTTATGAAGCCATGTATAGTACTTATGAACAGTTCCAACATACTTACGCTAAAACCTTGCAAACCAATGTGAAAGTGCAA
AACTATAAGGCGCGTGTTCATAAATACGATTCAGCACGTCAAGCTGCCATGGCTGCTAACTTTATTCCAGAAGCTGTTTA
CGATACCTTGTTAGAAACGGTTAATAAACATTTGCCACTCTTACACCGTTATTTGAAATTGCGTCAAGAGGTTCTTGGTT
TAGACGATTTGAAGATGTATGATGTTTACACACCATTATCTGAAACAGATTTAGCCATTGGTTATGATGAGGCTTTGGAA
AAGGCTGAGAAGGTTTTGGCTGTTTTTGGTAAGGATTACGCGGATCGTGTACATCGTGCTTTTACCGAACGTTGGATTGA
TGTTCACGTCAATAAAGGGAAGCGCTCTGGGGCTTATTCAGGTGGTTCCTATGATACCAATGCCTTCATGCTGTTGAACT
GGCAAGATACACTTGATAATCTTTACACACTTGTCCACGAAACAGGCCACAGTTTGCATTCTACTTTCACTCGTGAAACA
CAGCCTTATGTGTATGGGGATTATAGTATCTTCTTGGCAGAAATTGCATCCACAACGAATGAAAACATCATGACAGAAGC
TCTCTTAAATGAAGTGCAAGATGAGAAAGAACGCTTTGCCATTTTAAACCATTACCTCGATGGTTTCCGTGGAACAGTTT
TCCGTCAAACCCAATTTGCTGAGTTTGAACATGCCATTCATCAAGCTGATCAAAAAGGAGAAGTGTTAACAAGTGAATAC
CTTAACCAGCTATACGCTGATTTAAATGAAAAATATTATGGTTTAAGTAAAAAAGATAATCATTTTATTCAGTATGAATG
GGCACGTATTCCTCATTTCTATTACAATTATTATGTTTACCAATATGCAACAGGGTTTGCAGCTGCAAGCTATTTAGCGG
ATAAGATTGTGCATGGCACACAAGATGATATCGATCATTACTTGGCCTACCTCAAGTCAGGAAATTCTGATTACCCACTT
GAAGTGATTGCTAAAGCAGGCGTTGATATGGCAAAAGGTGATTATTTGGAAGCTGCCTTTAAAGTCTTTGACGAACGTCT
AACAGAACTTGAAGTACTCGTGTCCAAAGGCATACACAAAAGCTAA
ATGACTGATAATCGCAGCCATTTAGAAGAAAAATACACTTGGGATTTGAGCACTATTTTTGCAACAGATAAGGATTGGGA
AGCTGAAGTCAGTGACTTAGCTACTGAAATTGACGCGGCTAAGGATTTTTCAGGTCATTTACTAGATTCTAGCGCTAATC
TGTTGACAATTACAGATACTTATTTAGAGTTAGCTCGTCGTGTTGAGAAAGTCTATGTTTATGCTCACATGAAAAATGAC
CAAGACACTACTGTTGCCAAGTATCAAGAATACCAAGCTAAGGCTTCAGGCTTGTATGCAAAGTTTAGCGAAGTGTTTTC
ATTCTATGACCCAGAAGTTATGGCATTGAGTCAGGAAGATTACCAAGCTTTTCTTGCGGAAACACCTGATTTAAAAAGGT
ATCATCATTTCTTTGACAAATTGTTCCAGACACGTGACCATGTGCTCAGCCAGGCTGAAGAGGAATTATTAGCAGGAGCC
CAAGAAATTTTCAACGGCGCTGAAGAAACCTTTAGTATTCTTGATAACGCTGATATTGTCTTTCCAGTAGTTAAAAATGA
TAAGGGGGAAGATGTTGAATTAACCCATGGTAACTTCATTAGCCTAATGGAATCTAAGGACCGTAGCATTCGCCAAGCTG
CTTATGAAGCCATGTATAGTACTTATGAACAGTTCCAACATACTTACGCTAAAACCTTGCAAACCAATGTGAAAGTGCAA
AACTATAAGGCGCGTGTTCATAAATACGATTCAGCACGTCAAGCTGCCATGGCTGCTAACTTTATTCCAGAAGCTGTTTA
CGATACCTTGTTAGAAACGGTTAATAAACATTTGCCACTCTTACACCGTTATTTGAAATTGCGTCAAGAGGTTCTTGGTT
TAGACGATTTGAAGATGTATGATGTTTACACACCATTATCTGAAACAGATTTAGCCATTGGTTATGATGAGGCTTTGGAA
AAGGCTGAGAAGGTTTTGGCTGTTTTTGGTAAGGATTACGCGGATCGTGTACATCGTGCTTTTACCGAACGTTGGATTGA
TGTTCACGTCAATAAAGGGAAGCGCTCTGGGGCTTATTCAGGTGGTTCCTATGATACCAATGCCTTCATGCTGTTGAACT
GGCAAGATACACTTGATAATCTTTACACACTTGTCCACGAAACAGGCCACAGTTTGCATTCTACTTTCACTCGTGAAACA
CAGCCTTATGTGTATGGGGATTATAGTATCTTCTTGGCAGAAATTGCATCCACAACGAATGAAAACATCATGACAGAAGC
TCTCTTAAATGAAGTGCAAGATGAGAAAGAACGCTTTGCCATTTTAAACCATTACCTCGATGGTTTCCGTGGAACAGTTT
TCCGTCAAACCCAATTTGCTGAGTTTGAACATGCCATTCATCAAGCTGATCAAAAAGGAGAAGTGTTAACAAGTGAATAC
CTTAACCAGCTATACGCTGATTTAAATGAAAAATATTATGGTTTAAGTAAAAAAGATAATCATTTTATTCAGTATGAATG
GGCACGTATTCCTCATTTCTATTACAATTATTATGTTTACCAATATGCAACAGGGTTTGCAGCTGCAAGCTATTTAGCGG
ATAAGATTGTGCATGGCACACAAGATGATATCGATCATTACTTGGCCTACCTCAAGTCAGGAAATTCTGATTACCCACTT
GAAGTGATTGCTAAAGCAGGCGTTGATATGGCAAAAGGTGATTATTTGGAAGCTGCCTTTAAAGTCTTTGACGAACGTCT
AACAGAACTTGAAGTACTCGTGTCCAAAGGCATACACAAAAGCTAA
3D structure
| Source | ID | Structure |
|---|
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| pepF | Streptococcus salivarius strain HSISS4 |
71.215 |
100 |
0.712 |