Detailed information NTG1037540

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: ACB359_RS05665
• Genome accession: NZ_CP167013
• Coordinates: 1142314..1143351 (-)
• Length: 345 a.a.
• NCBI ID: WP_010922499.1
• Uniprot ID: A0A4U9I5V9
• Organism: Streptococcus pyogenes strain Isolate 16
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 1137314..1148351

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ACB359_RS05645 (ACB359_05645)	-	1138056..1138682 (+)	627	WP_002983834.1	A24 family peptidase	-
ACB359_RS05650 (ACB359_05650)	rlmN	1138764..1139843 (-)	1080	WP_031488529.1	23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN	-
ACB359_RS05655 (ACB359_05655)	-	1139847..1140467 (-)	621	WP_002992791.1	YutD family protein	-
ACB359_RS05660 (ACB359_05660)	-	1140915..1141892 (-)	978	WP_371399854.1	LacI family DNA-binding transcriptional regulator	-
ACB359_RS05665 (ACB359_05665)	sepM	1142314..1143351 (-)	1038	WP_010922499.1	SepM family pheromone-processing serine protease	Regulator
ACB359_RS05670 (ACB359_05670)	coaD	1143338..1143829 (-)	492	WP_002983821.1	pantetheine-phosphate adenylyltransferase	-
ACB359_RS05675 (ACB359_05675)	rsmD	1143819..1144358 (-)	540	WP_002983819.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
ACB359_RS05680 (ACB359_05680)	asnA	1144481..1145473 (-)	993	WP_002983817.1	aspartate--ammonia ligase	-
ACB359_RS05685 (ACB359_05685)	arcC	1145786..1146736 (-)	951	WP_010922501.1	carbamate kinase	-
ACB359_RS05690 (ACB359_05690)	-	1146756..1148087 (-)	1332	WP_030126384.1	dipeptidase	-

Sequence

Protein

• Length: 345 a.a.
• Molecular weight: 37541.24 Da
• Isoelectric Point: 9.6692

>NTDB_id=1037540 ACB359_RS05665 WP_010922499.1 1142314..1143351(-) (sepM) [Streptococcus pyogenes strain Isolate 16]
MKRLKKIKWWLVGLLALISLLLALFFPLPYYIEMPGGAYDIRTVLQVNGKEDKRKGAYQFVAVGISRASLAQLLYAWLTP
FTEISTAEDTTGGYSDADFLRINQFYMETSQNAAIYQALSLAGKPVTLDYKGVYVLDVNNESTFKGTLHLADTVTGVNGK
QFTSSAELIDYVSHLKLGDEVTVQFTSDNKPKKGVGRIIKLKNGKNGIGIALTDHTSVNSEDTVIFSTKGVGGPSAGLMF
TLDIYDQITKEDLRKGRTIAGTGTIGKDGEVGDIGGAGLKVVAAAEAGADIFFVPNNPVDKEIKKVNPNAISNYEEAKRA
AKRLKTKMKIVPVTTVQEALVYLRK

Nucleotide

• Length: 1038 bp

>NTDB_id=1037540 ACB359_RS05665 WP_010922499.1 1142314..1143351(-) (sepM) [Streptococcus pyogenes strain Isolate 16]
ATGAAAAGACTTAAAAAAATCAAATGGTGGTTAGTGGGTCTGCTAGCTTTAATCTCTTTATTGCTAGCGTTATTTTTTCC
GCTACCTTATTATATTGAAATGCCTGGAGGCGCTTACGATATTCGGACTGTCTTACAAGTCAATGGCAAAGAAGACAAAC
GAAAAGGAGCTTACCAGTTTGTTGCAGTGGGCATTAGTCGTGCCAGCCTCGCGCAGCTATTATATGCTTGGCTGACACCG
TTTACTGAAATTAGTACAGCAGAAGATACAACAGGCGGATACAGCGATGCTGATTTCCTTCGAATTAATCAATTCTACAT
GGAAACATCACAAAATGCAGCTATTTATCAAGCTTTATCCTTAGCTGGAAAACCAGTTACATTAGATTATAAAGGCGTAT
ATGTTTTAGACGTAAACAACGAATCTACTTTTAAAGGAACGTTACACTTAGCAGATACTGTAACAGGTGTAAATGGTAAA
CAGTTTACTAGTTCAGCAGAACTTATTGACTATGTTTCTCACCTAAAACTAGGGGATGAAGTTACGGTTCAGTTTACGAG
TGATAATAAGCCTAAAAAAGGAGTTGGCCGTATTATCAAACTGAAAAATGGGAAAAATGGGATTGGCATTGCCTTGACTG
ATCATACAAGTGTCAATTCAGAAGACACAGTGATCTTTAGTACTAAAGGAGTAGGAGGACCTAGTGCTGGTCTAATGTTT
ACTCTTGATATATATGATCAAATAACTAAAGAAGATTTACGCAAGGGCCGTACAATTGCAGGTACAGGAACTATTGGCAA
GGATGGCGAAGTAGGAGATATTGGTGGTGCAGGTCTTAAAGTAGTTGCAGCAGCTGAAGCTGGTGCAGATATATTTTTTG
TTCCGAATAATCCTGTTGATAAGGAAATTAAAAAAGTTAATCCAAATGCTATAAGTAATTACGAAGAAGCCAAACGGGCA
GCCAAACGACTAAAGACCAAAATGAAGATTGTTCCTGTTACGACTGTTCAAGAGGCACTGGTTTATCTTCGCAAATAA

Domains

Predicted by InterproScan.

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (233-309)

• PDZ domain (PDZ_2) (129-192)

3D structure

• AlphaFold DB: A0A4U9I5V9

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	69.275	100	0.693