Detailed information
Bioinformatically predicted
Overview
| Name | pepF | Type | Regulator |
| Locus tag | ACB343_RS05740 | Genome accession | NZ_CP167012 |
| Coordinates | 1135605..1137410 (-) | Length | 601 a.a. |
| NCBI ID | WP_011054652.1 | Uniprot ID | - |
| Organism | Streptococcus pyogenes strain Isolate 17 | ||
| Function | degradation of XIP; competence shut-off (predicted from homology) Competence regulation |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| ICE | 1115362..1162409 | 1135605..1137410 | within | 0 |
Gene organization within MGE regions
Location: 1115362..1162409
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| ACB343_RS05660 (ACB343_05660) | - | 1115400..1116674 (-) | 1275 | WP_011284930.1 | polysaccharide deacetylase family protein | - |
| ACB343_RS05665 (ACB343_05665) | - | 1116769..1118196 (-) | 1428 | WP_011284931.1 | NADP-dependent glyceraldehyde-3-phosphate dehydrogenase | - |
| ACB343_RS05670 (ACB343_05670) | ptsP | 1118381..1120114 (-) | 1734 | WP_002984033.1 | phosphoenolpyruvate--protein phosphotransferase | - |
| ACB343_RS05675 (ACB343_05675) | - | 1120119..1120382 (-) | 264 | WP_002984031.1 | phosphocarrier protein HPr | - |
| ACB343_RS05680 (ACB343_05680) | - | 1120775..1120993 (+) | 219 | WP_002989242.1 | redoxin NrdH | - |
| ACB343_RS05685 (ACB343_05685) | nrdE | 1121013..1123172 (+) | 2160 | WP_002993430.1 | class 1b ribonucleoside-diphosphate reductase subunit alpha | - |
| ACB343_RS05690 (ACB343_05690) | nrdF | 1123505..1124464 (+) | 960 | WP_011017933.1 | class 1b ribonucleoside-diphosphate reductase subunit beta | - |
| ACB343_RS05695 (ACB343_05695) | - | 1124526..1125743 (+) | 1218 | WP_371399988.1 | chloride channel protein | - |
| ACB343_RS05700 (ACB343_05700) | - | 1125839..1126995 (+) | 1157 | Protein_1077 | IS3 family transposase | - |
| ACB343_RS05705 (ACB343_05705) | - | 1127089..1127784 (-) | 696 | WP_002989227.1 | CPBP family intramembrane glutamic endopeptidase | - |
| ACB343_RS05710 (ACB343_05710) | - | 1127803..1128564 (-) | 762 | WP_002995753.1 | DUF3169 family protein | - |
| ACB343_RS05715 (ACB343_05715) | - | 1128561..1128776 (-) | 216 | WP_002989220.1 | helix-turn-helix transcriptional regulator | - |
| ACB343_RS05720 (ACB343_05720) | alaS | 1129137..1131755 (-) | 2619 | WP_011284933.1 | alanine--tRNA ligase | - |
| ACB343_RS05725 (ACB343_05725) | prsA | 1132142..1133197 (-) | 1056 | WP_002984003.1 | peptidylprolyl isomerase PrsA | - |
| ACB343_RS05730 (ACB343_05730) | - | 1133260..1133967 (-) | 708 | WP_011284934.1 | O-methyltransferase | - |
| ACB343_RS05735 (ACB343_05735) | - | 1134033..1135229 (-) | 1197 | WP_002995765.1 | OFA family MFS transporter | - |
| ACB343_RS05740 (ACB343_05740) | pepF | 1135605..1137410 (-) | 1806 | WP_011054652.1 | oligoendopeptidase F | Regulator |
| ACB343_RS05745 (ACB343_05745) | - | 1137423..1138385 (-) | 963 | WP_002995771.1 | competence protein CoiA | - |
| ACB343_RS05750 (ACB343_05750) | - | 1138680..1139396 (-) | 717 | WP_002989197.1 | pseudouridine synthase | - |
| ACB343_RS05755 (ACB343_05755) | nagB | 1139515..1140219 (-) | 705 | WP_021340997.1 | glucosamine-6-phosphate deaminase | - |
| ACB343_RS05760 (ACB343_05760) | queA | 1140421..1141449 (+) | 1029 | WP_011284937.1 | tRNA preQ1(34) S-adenosylmethionine ribosyltransferase-isomerase QueA | - |
| ACB343_RS05765 (ACB343_05765) | - | 1141456..1142676 (+) | 1221 | WP_002989189.1 | DUF3114 domain-containing protein | - |
| ACB343_RS05770 (ACB343_05770) | - | 1142790..1143380 (-) | 591 | WP_002989185.1 | serine hydrolase | - |
| ACB343_RS05775 (ACB343_05775) | - | 1143377..1143625 (-) | 249 | WP_002989183.1 | serine hydrolase | - |
| ACB343_RS05780 (ACB343_05780) | - | 1143681..1143836 (-) | 156 | WP_002989180.1 | hypothetical protein | - |
| ACB343_RS05785 (ACB343_05785) | sodA | 1144003..1144608 (-) | 606 | WP_002983977.1 | superoxide dismutase SodA | - |
| ACB343_RS05790 (ACB343_05790) | holA | 1144705..1145745 (-) | 1041 | WP_002989176.1 | DNA polymerase III subunit delta | - |
| ACB343_RS05795 (ACB343_05795) | - | 1145816..1148058 (-) | 2243 | Protein_1096 | DNA internalization-related competence protein ComEC/Rec2 | - |
| ACB343_RS05800 (ACB343_05800) | - | 1148039..1148701 (-) | 663 | WP_002983967.1 | ComEA family DNA-binding protein | - |
| ACB343_RS05805 (ACB343_05805) | - | 1148901..1149641 (-) | 741 | WP_021340996.1 | 1-acyl-sn-glycerol-3-phosphate acyltransferase | - |
| ACB343_RS05810 (ACB343_05810) | - | 1149759..1150535 (+) | 777 | WP_010922438.1 | tRNA1(Val) (adenine(37)-N6)-methyltransferase | - |
| ACB343_RS05815 (ACB343_05815) | - | 1150525..1150803 (+) | 279 | WP_011017953.1 | GIY-YIG nuclease family protein | - |
| ACB343_RS05820 (ACB343_05820) | - | 1150827..1152827 (-) | 2001 | WP_011284942.1 | potassium transporter Kup | - |
| ACB343_RS05825 (ACB343_05825) | - | 1152954..1154573 (-) | 1620 | WP_002989158.1 | DEAD/DEAH box helicase | - |
| ACB343_RS05830 (ACB343_05830) | - | 1154880..1156424 (-) | 1545 | WP_011284943.1 | peptide chain release factor 3 | - |
| ACB343_RS05835 (ACB343_05835) | - | 1156672..1157367 (-) | 696 | WP_011017956.1 | TIGR02206 family membrane protein | - |
| ACB343_RS05840 (ACB343_05840) | murF | 1157447..1158838 (-) | 1392 | WP_010922441.1 | UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase | - |
| ACB343_RS05845 (ACB343_05845) | - | 1159037..1160083 (-) | 1047 | WP_002989146.1 | D-alanine--D-alanine ligase | - |
| ACB343_RS05850 (ACB343_05850) | recR | 1160184..1160780 (-) | 597 | WP_002983939.1 | recombination mediator RecR | - |
| ACB343_RS05855 (ACB343_05855) | - | 1160827..1161018 (-) | 192 | WP_002983936.1 | hypothetical protein | - |
| ACB343_RS05860 (ACB343_05860) | - | 1161578..1162357 (-) | 780 | WP_014407680.1 | formate/nitrite transporter family protein | - |
Sequence
Protein
Download Length: 601 a.a. Molecular weight: 69341.19 Da Isoelectric Point: 4.7093
>NTDB_id=1037482 ACB343_RS05740 WP_011054652.1 1135605..1137410(-) (pepF) [Streptococcus pyogenes strain Isolate 17]
MTDNRSHLEEKYTWDLSTIFATDKDWEAEVSDLATEIDAAKDFSGHLLDSSANLLTITDTYLELARRVEKVYVYAHMKND
QDTTVAKYQEYQAKASGLYAKFSEVFSFYDPEVMALSQEDYQAFLAETPDLKRYHHFFDKLFQTRDHVLSQAEEELLAGA
QEIFNGAEETFSILDNADIVFPVVKNDKGEDVELTHGNFISLMESKDRSIRQAAYEAMYSTYEQFQHTYAKTLQTNVKVQ
NYKARVHKYDSARQAAMAANFIPEAVYDTLLETVNKHLPLLHRYLKLRQEVLGLDDLKMYDVYTPLSETDLAIGYDEALE
KAEKVLAVFGKDYADRVHRAFTERWIDVHVNKGKRSGAYSGGSYDTNAFMLLNWQDTLDNLYTLVHETGHSLHSTFTRET
QPYVYGDYSIFLAEIASTTNENIMTEALLNEVQDEKERFAILNHYLDGFRGTVFRQTQFAEFEHAIHQADQKGEVLTSEY
LNQLYADLNEKYYGLSKKDNHFIQYEWARIPHFYYNYYVYQYATGFAAASYLADKIVHGTQDDIDHYLAYLKSGNSDYPL
EVIAKAGVDMAKGDYLEAAFKVFDERLTELEVLVSKGIHKS
MTDNRSHLEEKYTWDLSTIFATDKDWEAEVSDLATEIDAAKDFSGHLLDSSANLLTITDTYLELARRVEKVYVYAHMKND
QDTTVAKYQEYQAKASGLYAKFSEVFSFYDPEVMALSQEDYQAFLAETPDLKRYHHFFDKLFQTRDHVLSQAEEELLAGA
QEIFNGAEETFSILDNADIVFPVVKNDKGEDVELTHGNFISLMESKDRSIRQAAYEAMYSTYEQFQHTYAKTLQTNVKVQ
NYKARVHKYDSARQAAMAANFIPEAVYDTLLETVNKHLPLLHRYLKLRQEVLGLDDLKMYDVYTPLSETDLAIGYDEALE
KAEKVLAVFGKDYADRVHRAFTERWIDVHVNKGKRSGAYSGGSYDTNAFMLLNWQDTLDNLYTLVHETGHSLHSTFTRET
QPYVYGDYSIFLAEIASTTNENIMTEALLNEVQDEKERFAILNHYLDGFRGTVFRQTQFAEFEHAIHQADQKGEVLTSEY
LNQLYADLNEKYYGLSKKDNHFIQYEWARIPHFYYNYYVYQYATGFAAASYLADKIVHGTQDDIDHYLAYLKSGNSDYPL
EVIAKAGVDMAKGDYLEAAFKVFDERLTELEVLVSKGIHKS
Nucleotide
Download Length: 1806 bp
>NTDB_id=1037482 ACB343_RS05740 WP_011054652.1 1135605..1137410(-) (pepF) [Streptococcus pyogenes strain Isolate 17]
ATGACTGATAATCGCAGCCATTTAGAAGAAAAATACACTTGGGATTTGAGCACTATTTTTGCAACAGATAAGGATTGGGA
AGCTGAAGTCAGTGACTTAGCTACTGAAATTGACGCGGCTAAGGATTTTTCAGGTCATTTACTAGATTCTAGCGCTAATC
TGTTGACAATTACAGATACTTATTTAGAGTTAGCTCGTCGTGTTGAGAAAGTCTATGTTTATGCTCACATGAAAAATGAC
CAAGACACTACTGTTGCCAAGTATCAAGAATACCAAGCTAAGGCTTCAGGCTTGTATGCAAAGTTTAGCGAAGTGTTTTC
ATTCTATGACCCAGAAGTTATGGCATTGAGTCAGGAAGATTACCAAGCTTTTCTTGCGGAAACACCTGATTTAAAAAGGT
ATCATCATTTCTTTGACAAATTGTTCCAGACACGTGACCATGTGCTCAGCCAGGCTGAAGAGGAATTATTAGCAGGAGCC
CAAGAAATTTTCAACGGCGCTGAAGAAACCTTTAGTATTCTTGATAACGCTGATATTGTCTTTCCAGTAGTTAAAAATGA
TAAGGGGGAAGATGTTGAATTAACCCATGGTAACTTCATTAGCCTAATGGAATCTAAGGACCGTAGCATTCGCCAAGCTG
CTTATGAAGCCATGTATAGTACTTATGAACAGTTCCAACATACTTACGCTAAAACCTTGCAAACCAATGTGAAAGTGCAA
AACTATAAGGCGCGTGTTCATAAATACGATTCAGCACGTCAAGCTGCCATGGCTGCTAACTTTATTCCAGAAGCTGTTTA
CGATACCTTGTTAGAAACGGTTAATAAACATTTGCCACTCTTACACCGTTATTTGAAATTGCGTCAAGAGGTTCTTGGTT
TAGACGATTTGAAGATGTATGATGTTTACACACCATTATCTGAAACAGATTTAGCCATTGGTTATGATGAGGCTTTGGAA
AAGGCTGAGAAGGTTTTGGCTGTTTTTGGTAAGGATTACGCGGATCGTGTACATCGTGCTTTTACCGAACGTTGGATTGA
TGTTCACGTCAATAAAGGGAAGCGCTCTGGGGCTTATTCAGGTGGTTCCTATGATACCAATGCCTTCATGCTGTTGAACT
GGCAAGATACACTTGATAATCTTTACACACTTGTCCACGAAACAGGCCACAGTTTGCATTCTACTTTCACTCGTGAAACA
CAGCCTTATGTGTATGGGGATTATAGTATCTTCTTGGCAGAAATTGCATCCACAACGAATGAAAACATCATGACAGAAGC
TCTCTTAAATGAAGTGCAAGATGAGAAAGAACGCTTTGCCATTTTAAACCATTACCTCGATGGTTTCCGTGGAACAGTTT
TCCGTCAAACCCAATTTGCTGAGTTTGAACATGCCATTCATCAAGCTGATCAAAAAGGAGAAGTGTTAACAAGTGAATAC
CTTAACCAGCTATACGCTGATTTAAATGAAAAATATTATGGTTTAAGTAAAAAAGATAATCATTTTATTCAGTATGAATG
GGCACGTATTCCTCATTTCTATTACAATTATTATGTTTACCAATATGCAACAGGGTTTGCAGCTGCAAGCTATTTAGCGG
ATAAGATTGTGCATGGCACACAAGATGATATCGATCATTACTTGGCCTACCTCAAGTCAGGAAATTCTGATTACCCACTT
GAAGTGATTGCTAAAGCAGGCGTTGATATGGCAAAAGGTGATTATTTGGAAGCTGCCTTTAAAGTCTTTGACGAACGTCT
AACAGAACTTGAAGTACTCGTGTCCAAAGGCATACACAAAAGCTAA
ATGACTGATAATCGCAGCCATTTAGAAGAAAAATACACTTGGGATTTGAGCACTATTTTTGCAACAGATAAGGATTGGGA
AGCTGAAGTCAGTGACTTAGCTACTGAAATTGACGCGGCTAAGGATTTTTCAGGTCATTTACTAGATTCTAGCGCTAATC
TGTTGACAATTACAGATACTTATTTAGAGTTAGCTCGTCGTGTTGAGAAAGTCTATGTTTATGCTCACATGAAAAATGAC
CAAGACACTACTGTTGCCAAGTATCAAGAATACCAAGCTAAGGCTTCAGGCTTGTATGCAAAGTTTAGCGAAGTGTTTTC
ATTCTATGACCCAGAAGTTATGGCATTGAGTCAGGAAGATTACCAAGCTTTTCTTGCGGAAACACCTGATTTAAAAAGGT
ATCATCATTTCTTTGACAAATTGTTCCAGACACGTGACCATGTGCTCAGCCAGGCTGAAGAGGAATTATTAGCAGGAGCC
CAAGAAATTTTCAACGGCGCTGAAGAAACCTTTAGTATTCTTGATAACGCTGATATTGTCTTTCCAGTAGTTAAAAATGA
TAAGGGGGAAGATGTTGAATTAACCCATGGTAACTTCATTAGCCTAATGGAATCTAAGGACCGTAGCATTCGCCAAGCTG
CTTATGAAGCCATGTATAGTACTTATGAACAGTTCCAACATACTTACGCTAAAACCTTGCAAACCAATGTGAAAGTGCAA
AACTATAAGGCGCGTGTTCATAAATACGATTCAGCACGTCAAGCTGCCATGGCTGCTAACTTTATTCCAGAAGCTGTTTA
CGATACCTTGTTAGAAACGGTTAATAAACATTTGCCACTCTTACACCGTTATTTGAAATTGCGTCAAGAGGTTCTTGGTT
TAGACGATTTGAAGATGTATGATGTTTACACACCATTATCTGAAACAGATTTAGCCATTGGTTATGATGAGGCTTTGGAA
AAGGCTGAGAAGGTTTTGGCTGTTTTTGGTAAGGATTACGCGGATCGTGTACATCGTGCTTTTACCGAACGTTGGATTGA
TGTTCACGTCAATAAAGGGAAGCGCTCTGGGGCTTATTCAGGTGGTTCCTATGATACCAATGCCTTCATGCTGTTGAACT
GGCAAGATACACTTGATAATCTTTACACACTTGTCCACGAAACAGGCCACAGTTTGCATTCTACTTTCACTCGTGAAACA
CAGCCTTATGTGTATGGGGATTATAGTATCTTCTTGGCAGAAATTGCATCCACAACGAATGAAAACATCATGACAGAAGC
TCTCTTAAATGAAGTGCAAGATGAGAAAGAACGCTTTGCCATTTTAAACCATTACCTCGATGGTTTCCGTGGAACAGTTT
TCCGTCAAACCCAATTTGCTGAGTTTGAACATGCCATTCATCAAGCTGATCAAAAAGGAGAAGTGTTAACAAGTGAATAC
CTTAACCAGCTATACGCTGATTTAAATGAAAAATATTATGGTTTAAGTAAAAAAGATAATCATTTTATTCAGTATGAATG
GGCACGTATTCCTCATTTCTATTACAATTATTATGTTTACCAATATGCAACAGGGTTTGCAGCTGCAAGCTATTTAGCGG
ATAAGATTGTGCATGGCACACAAGATGATATCGATCATTACTTGGCCTACCTCAAGTCAGGAAATTCTGATTACCCACTT
GAAGTGATTGCTAAAGCAGGCGTTGATATGGCAAAAGGTGATTATTTGGAAGCTGCCTTTAAAGTCTTTGACGAACGTCT
AACAGAACTTGAAGTACTCGTGTCCAAAGGCATACACAAAAGCTAA
3D structure
| Source | ID | Structure |
|---|
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| pepF | Streptococcus salivarius strain HSISS4 |
71.215 |
100 |
0.712 |