Detailed information NTG1037432

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: ACB355_RS06465
• Genome accession: NZ_CP167011
• Coordinates: 1274009..1275046 (-)
• Length: 345 a.a.
• NCBI ID: WP_010922499.1
• Uniprot ID: A0A4U9I5V9
• Organism: Streptococcus pyogenes strain Isolate 18
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 1269009..1280046

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ACB355_RS06445 (ACB355_06445)	-	1269759..1270385 (+)	627	WP_023079342.1	A24 family peptidase	-
ACB355_RS06450 (ACB355_06450)	rlmN	1270467..1271546 (-)	1080	WP_002992788.1	23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN	-
ACB355_RS06455 (ACB355_06455)	-	1271550..1272170 (-)	621	WP_161737269.1	YutD family protein	-
ACB355_RS06460 (ACB355_06460)	-	1272618..1273595 (-)	978	WP_002994809.1	LacI family DNA-binding transcriptional regulator	-
ACB355_RS06465 (ACB355_06465)	sepM	1274009..1275046 (-)	1038	WP_010922499.1	SepM family pheromone-processing serine protease	Regulator
ACB355_RS06470 (ACB355_06470)	coaD	1275033..1275524 (-)	492	WP_002983821.1	pantetheine-phosphate adenylyltransferase	-
ACB355_RS06475 (ACB355_06475)	rsmD	1275514..1276053 (-)	540	WP_002983819.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
ACB355_RS06480 (ACB355_06480)	asnA	1276176..1277168 (-)	993	WP_010922500.1	aspartate--ammonia ligase	-
ACB355_RS06485 (ACB355_06485)	arcC	1277481..1278431 (-)	951	WP_010922501.1	carbamate kinase	-
ACB355_RS06490 (ACB355_06490)	-	1278451..1279782 (-)	1332	WP_115224608.1	dipeptidase	-

Sequence

Protein

• Length: 345 a.a.
• Molecular weight: 37541.24 Da
• Isoelectric Point: 9.6692

>NTDB_id=1037432 ACB355_RS06465 WP_010922499.1 1274009..1275046(-) (sepM) [Streptococcus pyogenes strain Isolate 18]
MKRLKKIKWWLVGLLALISLLLALFFPLPYYIEMPGGAYDIRTVLQVNGKEDKRKGAYQFVAVGISRASLAQLLYAWLTP
FTEISTAEDTTGGYSDADFLRINQFYMETSQNAAIYQALSLAGKPVTLDYKGVYVLDVNNESTFKGTLHLADTVTGVNGK
QFTSSAELIDYVSHLKLGDEVTVQFTSDNKPKKGVGRIIKLKNGKNGIGIALTDHTSVNSEDTVIFSTKGVGGPSAGLMF
TLDIYDQITKEDLRKGRTIAGTGTIGKDGEVGDIGGAGLKVVAAAEAGADIFFVPNNPVDKEIKKVNPNAISNYEEAKRA
AKRLKTKMKIVPVTTVQEALVYLRK

Nucleotide

• Length: 1038 bp

>NTDB_id=1037432 ACB355_RS06465 WP_010922499.1 1274009..1275046(-) (sepM) [Streptococcus pyogenes strain Isolate 18]
ATGAAAAGACTTAAAAAAATCAAATGGTGGTTAGTGGGTCTGCTAGCTTTAATCTCTTTGTTGCTAGCGTTATTTTTTCC
GCTACCTTATTATATTGAAATGCCTGGAGGCGCTTACGATATTCGGACTGTCTTACAAGTCAATGGCAAAGAAGACAAAC
GAAAAGGAGCTTACCAGTTTGTTGCAGTGGGCATTAGTCGTGCCAGCCTCGCTCAGCTATTATATGCTTGGCTGACACCG
TTTACTGAAATTAGTACAGCAGAAGATACAACAGGCGGATACAGCGATGCTGATTTCCTTCGAATTAATCAATTTTACAT
GGAAACATCACAAAATGCAGCTATTTATCAAGCTTTATCCTTAGCTGGAAAACCAGTTACATTAGATTATAAAGGCGTAT
ATGTTTTAGACGTAAACAACGAATCTACTTTTAAAGGAACGCTACACTTAGCAGATACTGTAACAGGTGTAAATGGTAAA
CAGTTTACTAGTTCAGCAGAACTTATTGACTATGTTTCTCACCTAAAACTAGGGGATGAAGTTACGGTTCAGTTTACGAG
TGATAATAAGCCTAAAAAAGGAGTTGGCCGTATTATCAAACTGAAAAATGGGAAAAATGGGATTGGCATTGCCTTGACTG
ATCATACAAGTGTCAATTCAGAAGACACAGTGATCTTTAGTACTAAAGGAGTAGGAGGACCTAGTGCTGGTCTAATGTTT
ACTCTTGATATATATGATCAAATAACTAAAGAAGATTTACGCAAGGGCCGTACAATTGCAGGTACAGGAACTATTGGCAA
GGATGGCGAAGTAGGAGATATTGGTGGTGCAGGTCTTAAAGTAGTTGCAGCAGCTGAAGCTGGTGCAGATATATTTTTTG
TTCCGAATAATCCTGTTGATAAGGAAATTAAAAAAGTTAATCCAAATGCTATAAGTAATTACGAAGAAGCCAAACGGGCA
GCCAAACGACTAAAGACCAAAATGAAGATTGTTCCTGTTACGACTGTTCAAGAGGCACTGGTTTATCTTCGCAAATAA

Domains

Predicted by InterproScan.

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (233-309)

• PDZ domain (PDZ_2) (129-192)

3D structure

• AlphaFold DB: A0A4U9I5V9

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	69.275	100	0.693