Detailed information NTG1037372

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: ACB333_RS06320
• Genome accession: NZ_CP167010
• Coordinates: 1240158..1241195 (-)
• Length: 345 a.a.
• NCBI ID: WP_010922499.1
• Uniprot ID: A0A4U9I5V9
• Organism: Streptococcus pyogenes strain Isolate 20
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 1235158..1246195

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ACB333_RS06300 (ACB333_06305)	-	1235909..1236535 (+)	627	WP_010922497.1	A24 family peptidase	-
ACB333_RS06305 (ACB333_06310)	rlmN	1236617..1237696 (-)	1080	WP_002992788.1	23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN	-
ACB333_RS06310 (ACB333_06315)	-	1237700..1238320 (-)	621	WP_011285637.1	YutD family protein	-
ACB333_RS06315 (ACB333_06320)	-	1238768..1239744 (-)	977	Protein_1211	LacI family DNA-binding transcriptional regulator	-
ACB333_RS06320 (ACB333_06325)	sepM	1240158..1241195 (-)	1038	WP_010922499.1	SepM family pheromone-processing serine protease	Regulator
ACB333_RS06325 (ACB333_06330)	coaD	1241182..1241673 (-)	492	WP_002983821.1	pantetheine-phosphate adenylyltransferase	-
ACB333_RS06330 (ACB333_06335)	rsmD	1241663..1242202 (-)	540	WP_002983819.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
ACB333_RS06335 (ACB333_06340)	asnA	1242325..1243317 (-)	993	WP_010922500.1	aspartate--ammonia ligase	-
ACB333_RS06340 (ACB333_06345)	arcC	1243630..1244580 (-)	951	WP_010922501.1	carbamate kinase	-
ACB333_RS06345 (ACB333_06350)	-	1244600..1245931 (-)	1332	WP_011285641.1	dipeptidase	-

Sequence

Protein

• Length: 345 a.a.
• Molecular weight: 37541.24 Da
• Isoelectric Point: 9.6692

>NTDB_id=1037372 ACB333_RS06320 WP_010922499.1 1240158..1241195(-) (sepM) [Streptococcus pyogenes strain Isolate 20]
MKRLKKIKWWLVGLLALISLLLALFFPLPYYIEMPGGAYDIRTVLQVNGKEDKRKGAYQFVAVGISRASLAQLLYAWLTP
FTEISTAEDTTGGYSDADFLRINQFYMETSQNAAIYQALSLAGKPVTLDYKGVYVLDVNNESTFKGTLHLADTVTGVNGK
QFTSSAELIDYVSHLKLGDEVTVQFTSDNKPKKGVGRIIKLKNGKNGIGIALTDHTSVNSEDTVIFSTKGVGGPSAGLMF
TLDIYDQITKEDLRKGRTIAGTGTIGKDGEVGDIGGAGLKVVAAAEAGADIFFVPNNPVDKEIKKVNPNAISNYEEAKRA
AKRLKTKMKIVPVTTVQEALVYLRK

Nucleotide

• Length: 1038 bp

>NTDB_id=1037372 ACB333_RS06320 WP_010922499.1 1240158..1241195(-) (sepM) [Streptococcus pyogenes strain Isolate 20]
ATGAAAAGACTTAAAAAAATCAAATGGTGGTTAGTGGGTCTGCTAGCTTTAATCTCTTTGTTGCTAGCGTTATTTTTTCC
GCTACCTTATTATATTGAAATGCCTGGAGGCGCTTACGATATTCGGACTGTCTTACAAGTCAATGGCAAAGAAGACAAAC
GAAAAGGAGCTTACCAGTTTGTTGCAGTGGGCATTAGTCGTGCCAGCCTCGCTCAGCTATTATATGCTTGGCTGACACCG
TTTACTGAAATTAGTACAGCAGAAGATACAACAGGCGGATACAGCGATGCTGATTTCCTTCGAATTAATCAATTTTACAT
GGAAACATCACAAAATGCAGCTATTTATCAAGCTTTATCCTTAGCTGGAAAACCAGTTACATTAGATTATAAAGGCGTAT
ATGTTTTAGACGTAAACAACGAATCTACTTTTAAAGGAACGCTACACTTAGCAGATACTGTAACAGGTGTAAATGGTAAA
CAGTTTACTAGTTCAGCAGAACTTATTGACTATGTTTCTCACCTAAAACTAGGGGATGAAGTTACGGTTCAGTTTACGAG
TGATAATAAGCCTAAAAAAGGAGTTGGCCGTATTATCAAACTGAAAAATGGGAAAAATGGGATTGGCATTGCCTTGACTG
ATCATACAAGTGTCAATTCAGAAGACACAGTGATCTTTAGTACTAAAGGAGTAGGAGGACCTAGTGCTGGTCTAATGTTT
ACTCTTGATATATATGATCAAATAACTAAAGAAGATTTACGCAAGGGCCGTACAATTGCAGGTACAGGAACTATTGGCAA
GGATGGCGAAGTAGGAGATATTGGTGGTGCAGGTCTTAAAGTAGTTGCAGCAGCTGAAGCTGGTGCAGATATATTTTTTG
TTCCGAATAATCCTGTTGATAAGGAAATTAAAAAAGTTAATCCAAATGCTATAAGTAATTACGAAGAAGCCAAACGGGCA
GCCAAACGACTAAAGACCAAAATGAAGATTGTTCCTGTTACGACTGTTCAAGAGGCACTGGTTTATCTTCGCAAATAA

Domains

Predicted by InterproScan.

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (233-309)

• PDZ domain (PDZ_2) (129-192)

3D structure

• AlphaFold DB: A0A4U9I5V9

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	69.275	100	0.693