Detailed information NTG1037207

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: ACB342_RS06380
• Genome accession: NZ_CP167007
• Coordinates: 1246159..1247196 (-)
• Length: 345 a.a.
• NCBI ID: WP_010922499.1
• Uniprot ID: A0A4U9I5V9
• Organism: Streptococcus pyogenes strain Isolate 24
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 1241159..1252196

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ACB342_RS06360 (ACB342_06365)	-	1241910..1242536 (+)	627	WP_010922497.1	A24 family peptidase	-
ACB342_RS06365 (ACB342_06370)	rlmN	1242618..1243697 (-)	1080	WP_002992788.1	23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN	-
ACB342_RS06370 (ACB342_06375)	-	1243701..1244321 (-)	621	WP_011285637.1	YutD family protein	-
ACB342_RS06375 (ACB342_06380)	-	1244769..1245745 (-)	977	Protein_1210	LacI family DNA-binding transcriptional regulator	-
ACB342_RS06380 (ACB342_06385)	sepM	1246159..1247196 (-)	1038	WP_010922499.1	SepM family pheromone-processing serine protease	Regulator
ACB342_RS06385 (ACB342_06390)	coaD	1247183..1247674 (-)	492	WP_002983821.1	pantetheine-phosphate adenylyltransferase	-
ACB342_RS06390 (ACB342_06395)	rsmD	1247664..1248203 (-)	540	WP_002983819.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
ACB342_RS06395 (ACB342_06400)	asnA	1248326..1249318 (-)	993	WP_010922500.1	aspartate--ammonia ligase	-
ACB342_RS06400 (ACB342_06405)	arcC	1249631..1250581 (-)	951	WP_010922501.1	carbamate kinase	-
ACB342_RS06405 (ACB342_06410)	-	1250601..1251932 (-)	1332	WP_011285641.1	dipeptidase	-

Sequence

Protein

• Length: 345 a.a.
• Molecular weight: 37541.24 Da
• Isoelectric Point: 9.6692

>NTDB_id=1037207 ACB342_RS06380 WP_010922499.1 1246159..1247196(-) (sepM) [Streptococcus pyogenes strain Isolate 24]
MKRLKKIKWWLVGLLALISLLLALFFPLPYYIEMPGGAYDIRTVLQVNGKEDKRKGAYQFVAVGISRASLAQLLYAWLTP
FTEISTAEDTTGGYSDADFLRINQFYMETSQNAAIYQALSLAGKPVTLDYKGVYVLDVNNESTFKGTLHLADTVTGVNGK
QFTSSAELIDYVSHLKLGDEVTVQFTSDNKPKKGVGRIIKLKNGKNGIGIALTDHTSVNSEDTVIFSTKGVGGPSAGLMF
TLDIYDQITKEDLRKGRTIAGTGTIGKDGEVGDIGGAGLKVVAAAEAGADIFFVPNNPVDKEIKKVNPNAISNYEEAKRA
AKRLKTKMKIVPVTTVQEALVYLRK

Nucleotide

• Length: 1038 bp

>NTDB_id=1037207 ACB342_RS06380 WP_010922499.1 1246159..1247196(-) (sepM) [Streptococcus pyogenes strain Isolate 24]
ATGAAAAGACTTAAAAAAATCAAATGGTGGTTAGTGGGTCTGCTAGCTTTAATCTCTTTGTTGCTAGCGTTATTTTTTCC
GCTACCTTATTATATTGAAATGCCTGGAGGCGCTTACGATATTCGGACTGTCTTACAAGTCAATGGCAAAGAAGACAAAC
GAAAAGGAGCTTACCAGTTTGTTGCAGTGGGCATTAGTCGTGCCAGCCTCGCTCAGCTATTATATGCTTGGCTGACACCG
TTTACTGAAATTAGTACAGCAGAAGATACAACAGGCGGATACAGCGATGCTGATTTCCTTCGAATTAATCAATTTTACAT
GGAAACATCACAAAATGCAGCTATTTATCAAGCTTTATCCTTAGCTGGAAAACCAGTTACATTAGATTATAAAGGCGTAT
ATGTTTTAGACGTAAACAACGAATCTACTTTTAAAGGAACGCTACACTTAGCAGATACTGTAACAGGTGTAAATGGTAAA
CAGTTTACTAGTTCAGCAGAACTTATTGACTATGTTTCTCACCTAAAACTAGGGGATGAAGTTACGGTTCAGTTTACGAG
TGATAATAAGCCTAAAAAAGGAGTTGGCCGTATTATCAAACTGAAAAATGGGAAAAATGGGATTGGCATTGCCTTGACTG
ATCATACAAGTGTCAATTCAGAAGACACAGTGATCTTTAGTACTAAAGGAGTAGGAGGACCTAGTGCTGGTCTAATGTTT
ACTCTTGATATATATGATCAAATAACTAAAGAAGATTTACGCAAGGGCCGTACAATTGCAGGTACAGGAACTATTGGCAA
GGATGGCGAAGTAGGAGATATTGGTGGTGCAGGTCTTAAAGTAGTTGCAGCAGCTGAAGCTGGTGCAGATATATTTTTTG
TTCCGAATAATCCTGTTGATAAGGAAATTAAAAAAGTTAATCCAAATGCTATAAGTAATTACGAAGAAGCCAAACGGGCA
GCCAAACGACTAAAGACCAAAATGAAGATTGTTCCTGTTACGACTGTTCAAGAGGCACTGGTTTATCTTCGCAAATAA

Domains

Predicted by InterproScan.

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (233-309)

• PDZ domain (PDZ_2) (129-192)

3D structure

• AlphaFold DB: A0A4U9I5V9

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	69.275	100	0.693