Detailed information NTG1037157

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: ACB360_RS05545
• Genome accession: NZ_CP167006
• Coordinates: 1127685..1128722 (-)
• Length: 345 a.a.
• NCBI ID: WP_002989068.1
• Uniprot ID: Q1JKX2
• Organism: Streptococcus pyogenes strain Isolate 26
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 1122685..1133722

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ACB360_RS05520 (ACB360_05520)	-	1122689..1123216 (-)	528	WP_002983837.1	Dps family protein	-
ACB360_RS05525 (ACB360_05525)	-	1123444..1124070 (+)	627	WP_002989076.1	A24 family peptidase	-
ACB360_RS05530 (ACB360_05530)	rlmN	1124152..1125231 (-)	1080	WP_002989074.1	23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN	-
ACB360_RS05535 (ACB360_05535)	-	1125235..1125855 (-)	621	WP_032461520.1	YutD family protein	-
ACB360_RS05540 (ACB360_05540)	-	1126303..1127280 (-)	978	WP_002989070.1	LacI family DNA-binding transcriptional regulator	-
ACB360_RS05545 (ACB360_05545)	sepM	1127685..1128722 (-)	1038	WP_002989068.1	SepM family pheromone-processing serine protease	Regulator
ACB360_RS05550 (ACB360_05550)	coaD	1128709..1129200 (-)	492	WP_002983821.1	pantetheine-phosphate adenylyltransferase	-
ACB360_RS05555 (ACB360_05555)	rsmD	1129190..1129729 (-)	540	WP_002983819.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
ACB360_RS05560 (ACB360_05560)	asnA	1129852..1130844 (-)	993	WP_002983817.1	aspartate--ammonia ligase	-
ACB360_RS05565 (ACB360_05565)	arcC	1131158..1132108 (-)	951	WP_002989065.1	carbamate kinase	-
ACB360_RS05570 (ACB360_05570)	-	1132128..1133459 (-)	1332	WP_002989063.1	dipeptidase	-

Sequence

Protein

• Length: 345 a.a.
• Molecular weight: 37527.17 Da
• Isoelectric Point: 9.5788

>NTDB_id=1037157 ACB360_RS05545 WP_002989068.1 1127685..1128722(-) (sepM) [Streptococcus pyogenes strain Isolate 26]
MKRLNKIKWWLVGLLALISLLLALFFPLPYYIEMPGGAYDIRTVLQVNGKEDKRKGAYQFVAVGISRASLAQLLYAWLTP
FTEISTAEDTTGGYSDADFLRINQFYMETSQNAAIYQALSLAGKPVTLDYKGVYVLDVNNESTFKGTLHLADTVTGVNGK
QFTSSAELIDYVSHLKLGDEVTVQFTSDNKPKKGVGRIIKLKNGKNGIGIALTDHTSVNSEDTVIFSTKGVGGPSAGLMF
TLDIYDQITKEDLRKGRTIAGTGTIGKDGEVGDIGGAGLKVVAAAEAGADIFFVPNNPVDKEIKKVNPNAISNYEEAKRA
AKRLKTKMKIVPVTTVQEALVYLRK

Nucleotide

• Length: 1038 bp

>NTDB_id=1037157 ACB360_RS05545 WP_002989068.1 1127685..1128722(-) (sepM) [Streptococcus pyogenes strain Isolate 26]
ATGAAAAGACTTAACAAAATCAAATGGTGGTTAGTGGGTCTGCTAGCTTTAATCTCTTTGTTGCTAGCGTTATTTTTTCC
GCTACCTTATTATATTGAAATGCCTGGAGGCGCTTACGATATTCGGACTGTCTTACAAGTCAATGGCAAAGAAGACAAAC
GAAAAGGAGCTTACCAGTTTGTTGCAGTGGGCATTAGTCGTGCCAGCCTCGCTCAGCTATTATATGCTTGGCTGACACCG
TTTACTGAAATTAGTACAGCAGAAGATACAACAGGCGGATACAGCGATGCTGATTTCCTTCGAATTAATCAATTTTACAT
GGAAACATCACAAAATGCAGCTATTTATCAAGCTTTATCCTTAGCTGGAAAACCAGTTACATTAGATTATAAAGGCGTAT
ATGTTTTAGACGTAAACAACGAATCTACTTTTAAAGGAACGTTACACTTAGCAGATACTGTAACAGGTGTAAATGGTAAA
CAGTTTACTAGTTCAGCAGAACTTATTGACTATGTTTCTCACCTAAAACTAGGGGATGAAGTTACGGTTCAGTTTACGAG
TGATAATAAGCCTAAAAAAGGAGTTGGCCGTATTATCAAACTGAAAAATGGGAAAAATGGGATTGGCATTGCCTTGACTG
ATCATACAAGTGTCAATTCAGAAGACACAGTGATCTTTAGTACTAAAGGAGTAGGAGGACCTAGTGCTGGTCTAATGTTT
ACTCTTGATATATATGATCAAATAACTAAAGAAGATTTACGCAAGGGCCGTACAATTGCAGGTACAGGAACTATTGGCAA
GGATGGCGAAGTAGGAGATATTGGTGGTGCAGGTCTTAAAGTAGTTGCAGCAGCTGAAGCTGGTGCAGATATATTTTTTG
TTCCGAATAATCCTGTTGATAAGGAAATTAAAAAAGTTAATCCAAATGCTATAAGTAATTACGAAGAAGCCAAACGGGCA
GCCAAACGACTAAAGACCAAAATGAAGATTGTTCCTGTTACGACTGTTCAAGAGGCACTGGTTTATCTTCGCAAATAG

Domains

Predicted by InterproScan.

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (233-309)

• PDZ domain (PDZ_2) (129-192)

3D structure

• AlphaFold DB: Q1JKX2

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	68.986	100	0.69