Detailed information    

insolico Bioinformatically predicted

Overview

Name   cinA   Type   Machinery gene
Locus tag   ACB354_RS09435 Genome accession   NZ_CP167004
Coordinates   1817862..1819133 (-) Length   423 a.a.
NCBI ID   WP_011185061.1    Uniprot ID   Q5X9H9
Organism   Streptococcus pyogenes strain Isolate 28     
Function   require for competence (predicted from homology)   
Unclear

Genomic Context

Location: 1812862..1824133
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ACB354_RS09410 (ACB354_09415) - 1814833..1815138 (-) 306 WP_002982199.1 DUF1292 domain-containing protein -
  ACB354_RS09415 (ACB354_09420) ruvX 1815150..1815569 (-) 420 WP_002982196.1 Holliday junction resolvase RuvX -
  ACB354_RS09420 (ACB354_09425) - 1815566..1815835 (-) 270 WP_002982194.1 IreB family regulatory phosphoprotein -
  ACB354_RS09425 (ACB354_09430) spx 1815948..1816346 (-) 399 WP_002982188.1 transcriptional regulator Spx -
  ACB354_RS09430 (ACB354_09435) recA 1816637..1817773 (-) 1137 WP_002982186.1 recombinase RecA Machinery gene
  ACB354_RS09435 (ACB354_09440) cinA 1817862..1819133 (-) 1272 WP_011185061.1 competence/damage-inducible protein A Machinery gene
  ACB354_RS09440 (ACB354_09445) - 1819202..1819762 (-) 561 WP_021340449.1 DNA-3-methyladenine glycosylase I -
  ACB354_RS09445 (ACB354_09450) ruvA 1819772..1820368 (-) 597 WP_011185063.1 Holliday junction branch migration protein RuvA -
  ACB354_RS09450 (ACB354_09455) - 1820370..1821590 (-) 1221 WP_011018316.1 MFS transporter -
  ACB354_RS09455 (ACB354_09460) mutL 1821601..1823583 (-) 1983 WP_027968888.1 DNA mismatch repair endonuclease MutL -

Sequence

Protein


Download         Length: 423 a.a.        Molecular weight: 45895.59 Da        Isoelectric Point: 4.7648

>NTDB_id=1037063 ACB354_RS09435 WP_011185061.1 1817862..1819133(-) (cinA) [Streptococcus pyogenes strain Isolate 28]
MKAELIAVGTEILTGQIVNTNAQFLSEKMAELGIDVYFQTAVGDNEERLLSVITTASQRSDLVILCGGLGPTKDDLTKQT
LAKYLRKDLVYDEQACQKLDDFFAKRKPSSRTPNNERQAQVIEGSIPLPNKTGLAVGGFITVDGISYVVLPGPPSELKSM
VNEELVPLLSKQYSTLYSKVLRFFGVGESQLVTVLSDFIENQTDPTIAPYAKTGEVTLRLSTKTENQALADKKLGQLEAQ
LLSRKTLEGQPLADVFYGYGEDNSLARETFELLVKYDKTITAAESLTAGLFQSTLASFPGASQVFNGGFVAYSMEEKAKM
LGLPLEELKSHGVVSAYTAEGMAEQARLLTGADIGVSLTGVAGPDMLEEQPAGTVFIGLATQTKVESIKVLISGQSRLDV
RYIATLHAFNMVRKTLLKLENLL

Nucleotide


Download         Length: 1272 bp        

>NTDB_id=1037063 ACB354_RS09435 WP_011185061.1 1817862..1819133(-) (cinA) [Streptococcus pyogenes strain Isolate 28]
ATGAAAGCTGAACTGATTGCAGTAGGTACCGAAATTTTGACTGGTCAAATTGTGAATACCAATGCTCAATTTCTGTCGGA
AAAAATGGCAGAGCTAGGTATTGATGTCTATTTTCAAACGGCTGTTGGGGACAACGAGGAGCGTTTACTTTCAGTGATTA
CAACTGCTAGTCAGCGTAGTGACTTGGTGATTTTATGTGGTGGCCTTGGTCCAACGAAAGATGATTTAACCAAACAAACT
TTAGCAAAGTACCTTAGGAAAGACTTGGTTTATGATGAGCAAGCTTGTCAGAAACTAGATGACTTTTTTGCTAAGCGCAA
GCCTTCATCACGGACACCAAATAATGAGCGACAGGCACAAGTGATTGAAGGGTCAATCCCTTTGCCAAATAAAACTGGTC
TTGCGGTTGGTGGGTTCATCACAGTCGATGGTATTAGTTATGTTGTCTTACCGGGTCCTCCAAGTGAATTGAAGTCGATG
GTAAATGAAGAATTGGTACCACTTCTGTCAAAACAATACAGTACATTGTATTCAAAGGTACTACGCTTTTTTGGTGTTGG
GGAAAGTCAGTTGGTAACAGTTTTGTCAGATTTTATTGAGAATCAAACTGATCCAACCATTGCTCCGTATGCTAAGACTG
GCGAAGTGACTCTTCGCTTATCAACAAAAACTGAAAACCAAGCTCTGGCAGATAAAAAGTTAGGTCAGCTAGAAGCGCAG
CTACTATCCCGAAAAACTCTTGAAGGTCAACCCTTAGCTGATGTCTTTTATGGCTATGGGGAGGATAATTCCTTAGCGCG
TGAGACATTTGAGCTCTTAGTAAAATATGATAAGACAATTACAGCAGCAGAAAGTCTAACCGCGGGATTATTTCAGTCAA
CTTTGGCGAGTTTTCCAGGAGCTTCTCAAGTATTCAATGGAGGCTTTGTGGCTTATAGCATGGAAGAAAAAGCGAAAATG
CTAGGCCTTCCTTTAGAGGAGTTGAAATCGCATGGCGTTGTTAGTGCTTATACAGCCGAGGGGATGGCGGAGCAAGCAAG
GTTATTGACTGGTGCTGATATTGGGGTAAGTTTAACAGGTGTTGCCGGACCAGATATGTTGGAGGAACAGCCTGCAGGTA
CAGTTTTCATTGGCCTTGCCACTCAAACTAAGGTAGAATCAATAAAGGTTTTGATTAGCGGGCAAAGTCGTTTGGATGTG
CGCTATATCGCCACTTTACATGCCTTTAATATGGTCCGTAAAACTTTATTAAAACTTGAGAATTTGCTATAA

Domains

Predicted by InterproScan.

Competence-damaged protein (CinA)

(263-416)

Damage-inducible protein CinA KH domain (CinA_KH)

(178-243)

Probable molybdopterin binding domain (MoCF_biosynth)

(5-170)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB Q5X9H9

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  cinA Streptococcus mutans UA159

68.794

100

0.688
  cinA Streptococcus mitis SK321

69.065

98.582

0.681
  cinA Streptococcus mitis NCTC 12261

68.585

98.582

0.676
  cinA Streptococcus pneumoniae TIGR4

67.626

98.582

0.667
  cinA Streptococcus pneumoniae Rx1

67.626

98.582

0.667
  cinA Streptococcus pneumoniae R6

67.626

98.582

0.667
  cinA Streptococcus pneumoniae D39

67.386

98.582

0.664
  cinA Streptococcus suis isolate S10

52.885

98.345

0.52
  cinA Bacillus subtilis subsp. subtilis str. 168

46.172

98.818

0.456

Multiple sequence alignment