Detailed information
Bioinformatically predicted
Overview
| Name | pepF | Type | Regulator |
| Locus tag | ACB354_RS04250 | Genome accession | NZ_CP167004 |
| Coordinates | 773202..775007 (+) | Length | 601 a.a. |
| NCBI ID | WP_002995768.1 | Uniprot ID | A0A660A6L4 |
| Organism | Streptococcus pyogenes strain Isolate 28 | ||
| Function | degradation of XIP; competence shut-off (predicted from homology) Competence regulation |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| ICE | 739843..792838 | 773202..775007 | within | 0 |
Gene organization within MGE regions
Location: 739843..792838
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| ACB354_RS04080 (ACB354_04080) | - | 740150..740671 (+) | 522 | WP_011017960.1 | transcription repressor NadR | - |
| ACB354_RS04085 (ACB354_04085) | - | 740832..741374 (+) | 543 | WP_011017959.1 | hypothetical protein | - |
| ACB354_RS04090 (ACB354_04090) | - | 741498..742277 (+) | 780 | WP_021340400.1 | formate/nitrite transporter family protein | - |
| ACB354_RS04095 (ACB354_04095) | - | 742837..743019 (+) | 183 | WP_011888786.1 | penicillin-binding protein | - |
| ACB354_RS04100 (ACB354_04100) | recR | 743066..743662 (+) | 597 | WP_002983939.1 | recombination mediator RecR | - |
| ACB354_RS04105 (ACB354_04105) | - | 743763..744809 (+) | 1047 | WP_002994369.1 | D-alanine--D-alanine ligase | - |
| ACB354_RS04110 (ACB354_04110) | murF | 745008..746399 (+) | 1392 | WP_011184722.1 | UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase | - |
| ACB354_RS04115 (ACB354_04115) | - | 746479..747174 (+) | 696 | WP_011017956.1 | TIGR02206 family membrane protein | - |
| ACB354_RS04120 (ACB354_04120) | - | 747422..748966 (+) | 1545 | WP_011017955.1 | peptide chain release factor 3 | - |
| ACB354_RS04125 (ACB354_04125) | - | 749273..750892 (+) | 1620 | WP_011184720.1 | DEAD/DEAH box helicase | - |
| ACB354_RS04130 (ACB354_04130) | - | 751020..753020 (+) | 2001 | WP_011184719.1 | potassium transporter Kup | - |
| ACB354_RS04135 (ACB354_04135) | - | 753044..753322 (-) | 279 | WP_011017953.1 | GIY-YIG nuclease family protein | - |
| ACB354_RS04140 (ACB354_04140) | - | 753312..754088 (-) | 777 | WP_021340248.1 | tRNA1(Val) (adenine(37)-N6)-methyltransferase | - |
| ACB354_RS04145 (ACB354_04145) | - | 754206..754946 (+) | 741 | WP_021340247.1 | 1-acyl-sn-glycerol-3-phosphate acyltransferase | - |
| ACB354_RS04150 (ACB354_04150) | - | 755145..755807 (+) | 663 | WP_011184716.1 | ComEA family DNA-binding protein | - |
| ACB354_RS04155 (ACB354_04155) | - | 755788..757341 (+) | 1554 | Protein_758 | ComEC/Rec2 family competence protein | - |
| ACB354_RS04160 (ACB354_04160) | - | 757338..757754 (-) | 417 | Protein_759 | IS982-like element ISSpy2 family transposase | - |
| ACB354_RS04165 (ACB354_04165) | - | 758174..758323 (+) | 150 | WP_168637291.1 | hypothetical protein | - |
| ACB354_RS04170 (ACB354_04170) | - | 758310..762182 (+) | 3873 | WP_371399123.1 | adhesin | - |
| ACB354_RS04175 (ACB354_04175) | - | 762443..762844 (+) | 402 | WP_011184713.1 | hypothetical protein | - |
| ACB354_RS04180 (ACB354_04180) | - | 762864..762929 (+) | 66 | WP_371399130.1 | hypothetical protein | - |
| ACB354_RS04185 (ACB354_04185) | - | 762989..763477 (+) | 489 | WP_345770114.1 | recombinase zinc beta ribbon domain-containing protein | - |
| ACB354_RS04190 (ACB354_04190) | - | 763766..764191 (+) | 426 | WP_126409737.1 | hypothetical protein | - |
| ACB354_RS04195 (ACB354_04195) | - | 764222..764803 (+) | 582 | Protein_766 | ComEC/Rec2 family competence protein | - |
| ACB354_RS04200 (ACB354_04200) | holA | 764884..765924 (+) | 1041 | WP_011184669.1 | DNA polymerase III subunit delta | - |
| ACB354_RS04205 (ACB354_04205) | sodA | 766021..766626 (+) | 606 | WP_011184668.1 | superoxide dismutase SodA | - |
| ACB354_RS04210 (ACB354_04210) | - | 766793..766939 (+) | 147 | WP_011017947.1 | hypothetical protein | - |
| ACB354_RS04215 (ACB354_04215) | - | 766995..767234 (+) | 240 | WP_011184667.1 | hypothetical protein | - |
| ACB354_RS04220 (ACB354_04220) | - | 767231..767821 (+) | 591 | WP_371399124.1 | serine hydrolase | - |
| ACB354_RS04225 (ACB354_04225) | - | 767935..769155 (-) | 1221 | WP_011184665.1 | DUF3114 domain-containing protein | - |
| ACB354_RS04230 (ACB354_04230) | queA | 769162..770190 (-) | 1029 | WP_011184664.1 | tRNA preQ1(34) S-adenosylmethionine ribosyltransferase-isomerase QueA | - |
| ACB354_RS04235 (ACB354_04235) | nagB | 770392..771096 (+) | 705 | WP_021340443.1 | glucosamine-6-phosphate deaminase | - |
| ACB354_RS04240 (ACB354_04240) | - | 771215..771931 (+) | 717 | WP_011184662.1 | pseudouridine synthase | - |
| ACB354_RS04245 (ACB354_04245) | - | 772227..773189 (+) | 963 | WP_002983995.1 | competence protein CoiA | - |
| ACB354_RS04250 (ACB354_04250) | pepF | 773202..775007 (+) | 1806 | WP_002995768.1 | oligoendopeptidase F | Regulator |
| ACB354_RS04255 (ACB354_04255) | - | 775383..776579 (+) | 1197 | WP_002995765.1 | OFA family MFS transporter | - |
| ACB354_RS04260 (ACB354_04260) | - | 776645..777352 (+) | 708 | WP_011017939.1 | O-methyltransferase | - |
| ACB354_RS04265 (ACB354_04265) | prsA | 777415..778470 (+) | 1056 | WP_011184661.1 | peptidylprolyl isomerase PrsA | - |
| ACB354_RS04270 (ACB354_04270) | alaS | 778857..781475 (+) | 2619 | WP_011184660.1 | alanine--tRNA ligase | - |
| ACB354_RS04275 (ACB354_04275) | - | 781836..782051 (+) | 216 | WP_002989220.1 | helix-turn-helix transcriptional regulator | - |
| ACB354_RS04280 (ACB354_04280) | - | 782048..782809 (+) | 762 | WP_011184659.1 | DUF3169 family protein | - |
| ACB354_RS04285 (ACB354_04285) | - | 782828..783523 (+) | 696 | WP_011184658.1 | CPBP family intramembrane glutamic endopeptidase | - |
| ACB354_RS04290 (ACB354_04290) | - | 783620..784770 (-) | 1151 | Protein_785 | IS3 family transposase | - |
| ACB354_RS04295 (ACB354_04295) | - | 784908..786134 (-) | 1227 | WP_021733864.1 | chloride channel protein | - |
| ACB354_RS04300 (ACB354_04300) | nrdF | 786196..787155 (-) | 960 | WP_011017933.1 | class 1b ribonucleoside-diphosphate reductase subunit beta | - |
| ACB354_RS04305 (ACB354_04305) | nrdE | 787359..789518 (-) | 2160 | WP_011184652.1 | class 1b ribonucleoside-diphosphate reductase subunit alpha | - |
| ACB354_RS04310 (ACB354_04310) | - | 789538..789756 (-) | 219 | WP_002989242.1 | redoxin NrdH | - |
| ACB354_RS04315 (ACB354_04315) | - | 790149..790412 (+) | 264 | WP_002984031.1 | phosphocarrier protein HPr | - |
| ACB354_RS04320 (ACB354_04320) | ptsP | 790417..792150 (+) | 1734 | WP_002984033.1 | phosphoenolpyruvate--protein phosphotransferase | - |
Sequence
Protein
Download Length: 601 a.a. Molecular weight: 69394.45 Da Isoelectric Point: 4.8408
>NTDB_id=1037042 ACB354_RS04250 WP_002995768.1 773202..775007(+) (pepF) [Streptococcus pyogenes strain Isolate 28]
MTDNRSHLEEKYTWDLSTIFATDKDWEAEVSDLATEVEASKGFAGHLLDSSANLLKVTKTYLELARRVEKVYVYAHMKND
QDTTVAKYQEYQAKASGLYAKFSEVFSFYDPEVMMLHQEDYQAFLTETPELKVYNHFFDKLFQAREHVLSQAEEELLAGA
QEIFNGAEETFSILDNADIVFPIVRNDKGENVELTHGNFISLMESKDRSVRQAAYEAMYSTYEQFQHTYAKTLQTNVKVQ
NYKARVHKYDSARQAAMAANFIPEAVYDTLLETVNKHLPLLHRYLKLRQEVLGLDDLKMYDVYTPLSETDLAIGYDEALE
KAEKVLAVFGKDYADRVHRAFTERWIDVHVNKGKRSGAYSGGSYDTNAFMLLNWQDTLDNLYTLVHETGHSLHSTFTRET
QPYVYGDYSIFLAEIASTTNENIMTEALLNEVQDEKERFAILNHYLDGFRGTVFRQTQFAEFEHAIHQADQKGEVLTSEY
LNQLYADLNEKYYGLSKKDNHFIQYEWARIPHFYYNYYVYQYATGFAAASYLADKIVHGTQDDIDHYLAYLKSGNSDYPL
EVIAKAGVDMAKGDYLEAAFKVFDERLTELEVLVSKGIHKS
MTDNRSHLEEKYTWDLSTIFATDKDWEAEVSDLATEVEASKGFAGHLLDSSANLLKVTKTYLELARRVEKVYVYAHMKND
QDTTVAKYQEYQAKASGLYAKFSEVFSFYDPEVMMLHQEDYQAFLTETPELKVYNHFFDKLFQAREHVLSQAEEELLAGA
QEIFNGAEETFSILDNADIVFPIVRNDKGENVELTHGNFISLMESKDRSVRQAAYEAMYSTYEQFQHTYAKTLQTNVKVQ
NYKARVHKYDSARQAAMAANFIPEAVYDTLLETVNKHLPLLHRYLKLRQEVLGLDDLKMYDVYTPLSETDLAIGYDEALE
KAEKVLAVFGKDYADRVHRAFTERWIDVHVNKGKRSGAYSGGSYDTNAFMLLNWQDTLDNLYTLVHETGHSLHSTFTRET
QPYVYGDYSIFLAEIASTTNENIMTEALLNEVQDEKERFAILNHYLDGFRGTVFRQTQFAEFEHAIHQADQKGEVLTSEY
LNQLYADLNEKYYGLSKKDNHFIQYEWARIPHFYYNYYVYQYATGFAAASYLADKIVHGTQDDIDHYLAYLKSGNSDYPL
EVIAKAGVDMAKGDYLEAAFKVFDERLTELEVLVSKGIHKS
Nucleotide
Download Length: 1806 bp
>NTDB_id=1037042 ACB354_RS04250 WP_002995768.1 773202..775007(+) (pepF) [Streptococcus pyogenes strain Isolate 28]
ATGACTGATAATCGCAGCCATTTAGAAGAAAAATACACTTGGGATTTGAGCACTATTTTTGCAACAGATAAGGATTGGGA
AGCTGAAGTCAGTGACTTAGCTACTGAAGTTGAGGCATCTAAAGGTTTTGCTGGTCATTTGCTGGATTCTAGTGCTAATT
TGTTAAAGGTTACAAAAACATATTTAGAATTGGCTCGTCGTGTGGAGAAAGTCTATGTTTATGCTCACATGAAAAATGAC
CAAGACACTACTGTTGCCAAGTATCAAGAATACCAAGCTAAGGCTTCAGGCTTGTATGCAAAGTTTAGCGAAGTCTTTTC
ATTCTATGATCCAGAAGTGATGATGCTTCATCAAGAAGACTATCAGGCTTTCCTTACTGAAACCCCTGAGTTGAAAGTGT
ACAACCATTTCTTTGACAAATTATTCCAAGCCCGCGAACATGTTCTTAGTCAAGCAGAAGAGGAATTATTAGCAGGAGCT
CAAGAAATTTTCAATGGTGCGGAAGAAACCTTTAGTATTCTTGATAACGCTGACATTGTTTTCCCGATAGTCAGAAATGA
TAAAGGTGAAAACGTTGAATTAACCCATGGTAACTTCATTAGCCTAATGGAATCTAAGGACCGTAGCGTTCGCCAAGCTG
CTTATGAAGCCATGTATAGTACTTATGAACAGTTCCAACATACTTACGCTAAAACCTTGCAAACCAATGTGAAAGTGCAA
AACTATAAGGCGCGTGTTCATAAATACGATTCAGCACGTCAAGCTGCCATGGCTGCTAACTTTATTCCAGAAGCTGTTTA
CGACACTTTATTAGAAACGGTTAACAAACATTTACCACTCTTGCACCGTTATTTGAAATTGCGTCAAGAGGTTCTTGGTT
TAGACGATTTGAAGATGTATGATGTTTACACACCATTATCTGAAACAGATCTAGCCATTGGTTATGATGAGGCTTTGGAA
AAGGCTGAGAAGGTTTTGGCTGTTTTTGGTAAAGATTACGCAGATCGTGTGCATCGTGCTTTTACCGAACGTTGGATTGA
TGTTCATGTCAATAAAGGGAAGCGTTCTGGAGCTTATTCGGGTGGTTCCTATGATACCAATGCCTTTATGCTATTAAACT
GGCAAGATACCTTAGACAATCTATACACTTTAGTTCATGAAACTGGGCACAGTTTGCATTCTACTTTCACTCGTGAAACA
CAGCCTTATGTGTATGGAGATTACAGTATTTTCTTGGCAGAAATTGCATCCACAACGAATGAAAATATTATGACAGAAGC
TCTCTTAAATGAGGTTCAAGATGAGAAAGAACGCTTTGCCATTTTAAACCATTACCTCGATGGTTTCCGTGGAACAGTTT
TCCGTCAAACCCAATTTGCTGAGTTTGAACATGCCATTCATCAAGCTGATCAAAAAGGAGAAGTGTTAACAAGTGAATAC
CTTAACCAGCTATACGCTGATTTAAATGAAAAATATTATGGTTTAAGTAAAAAAGATAATCATTTTATTCAGTATGAATG
GGCACGTATTCCTCATTTCTATTACAATTATTATGTTTACCAATATGCAACAGGTTTTGCAGCTGCAAGCTATTTAGCGG
ATAAGATTGTGCATGGCACACAAGATGATATCGATCATTACTTGGCCTACCTCAAGTCAGGAAATTCTGATTACCCACTT
GAAGTGATTGCTAAAGCAGGCGTTGATATGGCAAAAGGTGATTATTTGGAAGCCGCCTTTAAAGTCTTTGACGAACGTCT
AACAGAACTTGAAGTACTCGTGTCCAAAGGCATACACAAAAGCTAA
ATGACTGATAATCGCAGCCATTTAGAAGAAAAATACACTTGGGATTTGAGCACTATTTTTGCAACAGATAAGGATTGGGA
AGCTGAAGTCAGTGACTTAGCTACTGAAGTTGAGGCATCTAAAGGTTTTGCTGGTCATTTGCTGGATTCTAGTGCTAATT
TGTTAAAGGTTACAAAAACATATTTAGAATTGGCTCGTCGTGTGGAGAAAGTCTATGTTTATGCTCACATGAAAAATGAC
CAAGACACTACTGTTGCCAAGTATCAAGAATACCAAGCTAAGGCTTCAGGCTTGTATGCAAAGTTTAGCGAAGTCTTTTC
ATTCTATGATCCAGAAGTGATGATGCTTCATCAAGAAGACTATCAGGCTTTCCTTACTGAAACCCCTGAGTTGAAAGTGT
ACAACCATTTCTTTGACAAATTATTCCAAGCCCGCGAACATGTTCTTAGTCAAGCAGAAGAGGAATTATTAGCAGGAGCT
CAAGAAATTTTCAATGGTGCGGAAGAAACCTTTAGTATTCTTGATAACGCTGACATTGTTTTCCCGATAGTCAGAAATGA
TAAAGGTGAAAACGTTGAATTAACCCATGGTAACTTCATTAGCCTAATGGAATCTAAGGACCGTAGCGTTCGCCAAGCTG
CTTATGAAGCCATGTATAGTACTTATGAACAGTTCCAACATACTTACGCTAAAACCTTGCAAACCAATGTGAAAGTGCAA
AACTATAAGGCGCGTGTTCATAAATACGATTCAGCACGTCAAGCTGCCATGGCTGCTAACTTTATTCCAGAAGCTGTTTA
CGACACTTTATTAGAAACGGTTAACAAACATTTACCACTCTTGCACCGTTATTTGAAATTGCGTCAAGAGGTTCTTGGTT
TAGACGATTTGAAGATGTATGATGTTTACACACCATTATCTGAAACAGATCTAGCCATTGGTTATGATGAGGCTTTGGAA
AAGGCTGAGAAGGTTTTGGCTGTTTTTGGTAAAGATTACGCAGATCGTGTGCATCGTGCTTTTACCGAACGTTGGATTGA
TGTTCATGTCAATAAAGGGAAGCGTTCTGGAGCTTATTCGGGTGGTTCCTATGATACCAATGCCTTTATGCTATTAAACT
GGCAAGATACCTTAGACAATCTATACACTTTAGTTCATGAAACTGGGCACAGTTTGCATTCTACTTTCACTCGTGAAACA
CAGCCTTATGTGTATGGAGATTACAGTATTTTCTTGGCAGAAATTGCATCCACAACGAATGAAAATATTATGACAGAAGC
TCTCTTAAATGAGGTTCAAGATGAGAAAGAACGCTTTGCCATTTTAAACCATTACCTCGATGGTTTCCGTGGAACAGTTT
TCCGTCAAACCCAATTTGCTGAGTTTGAACATGCCATTCATCAAGCTGATCAAAAAGGAGAAGTGTTAACAAGTGAATAC
CTTAACCAGCTATACGCTGATTTAAATGAAAAATATTATGGTTTAAGTAAAAAAGATAATCATTTTATTCAGTATGAATG
GGCACGTATTCCTCATTTCTATTACAATTATTATGTTTACCAATATGCAACAGGTTTTGCAGCTGCAAGCTATTTAGCGG
ATAAGATTGTGCATGGCACACAAGATGATATCGATCATTACTTGGCCTACCTCAAGTCAGGAAATTCTGATTACCCACTT
GAAGTGATTGCTAAAGCAGGCGTTGATATGGCAAAAGGTGATTATTTGGAAGCCGCCTTTAAAGTCTTTGACGAACGTCT
AACAGAACTTGAAGTACTCGTGTCCAAAGGCATACACAAAAGCTAA
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| pepF | Streptococcus salivarius strain HSISS4 |
70.715 |
100 |
0.707 |