Detailed information NTG1037038

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: ACB354_RS03570
• Genome accession: NZ_CP167004
• Coordinates: 656487..657524 (+)
• Length: 345 a.a.
• NCBI ID: WP_010922499.1
• Uniprot ID: A0A4U9I5V9
• Organism: Streptococcus pyogenes strain Isolate 28
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 651487..662524

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ACB354_RS03545 (ACB354_03545)	-	651751..653082 (+)	1332	WP_011184765.1	dipeptidase	-
ACB354_RS03550 (ACB354_03550)	arcC	653102..654052 (+)	951	WP_011018011.1	carbamate kinase	-
ACB354_RS03555 (ACB354_03555)	asnA	654365..655357 (+)	993	WP_011184764.1	aspartate--ammonia ligase	-
ACB354_RS03560 (ACB354_03560)	rsmD	655480..656019 (+)	540	WP_002983819.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
ACB354_RS03565 (ACB354_03565)	coaD	656009..656500 (+)	492	WP_002983821.1	pantetheine-phosphate adenylyltransferase	-
ACB354_RS03570 (ACB354_03570)	sepM	656487..657524 (+)	1038	WP_010922499.1	SepM family pheromone-processing serine protease	Regulator
ACB354_RS03575 (ACB354_03575)	-	657940..658916 (+)	977	Protein_642	LacI family DNA-binding transcriptional regulator	-
ACB354_RS03580 (ACB354_03580)	-	659364..659984 (+)	621	WP_002992791.1	YutD family protein	-
ACB354_RS03585 (ACB354_03585)	rlmN	659988..661067 (+)	1080	WP_011184761.1	23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN	-
ACB354_RS03590 (ACB354_03590)	-	661149..661775 (-)	627	WP_011184760.1	A24 family peptidase	-

Sequence

Protein

• Length: 345 a.a.
• Molecular weight: 37541.24 Da
• Isoelectric Point: 9.6692

>NTDB_id=1037038 ACB354_RS03570 WP_010922499.1 656487..657524(+) (sepM) [Streptococcus pyogenes strain Isolate 28]
MKRLKKIKWWLVGLLALISLLLALFFPLPYYIEMPGGAYDIRTVLQVNGKEDKRKGAYQFVAVGISRASLAQLLYAWLTP
FTEISTAEDTTGGYSDADFLRINQFYMETSQNAAIYQALSLAGKPVTLDYKGVYVLDVNNESTFKGTLHLADTVTGVNGK
QFTSSAELIDYVSHLKLGDEVTVQFTSDNKPKKGVGRIIKLKNGKNGIGIALTDHTSVNSEDTVIFSTKGVGGPSAGLMF
TLDIYDQITKEDLRKGRTIAGTGTIGKDGEVGDIGGAGLKVVAAAEAGADIFFVPNNPVDKEIKKVNPNAISNYEEAKRA
AKRLKTKMKIVPVTTVQEALVYLRK

Nucleotide

• Length: 1038 bp

>NTDB_id=1037038 ACB354_RS03570 WP_010922499.1 656487..657524(+) (sepM) [Streptococcus pyogenes strain Isolate 28]
ATGAAAAGACTTAAAAAAATCAAATGGTGGTTAGTGGGTCTGCTAGCTTTAATCTCTTTGTTGCTAGCGTTATTTTTTCC
GCTACCTTATTATATTGAAATGCCTGGAGGCGCTTACGATATTCGGACTGTCTTACAAGTCAATGGCAAAGAAGACAAAC
GAAAAGGAGCTTACCAGTTTGTTGCAGTGGGCATTAGTCGTGCCAGCCTCGCGCAGCTATTATATGCTTGGCTGACACCG
TTTACTGAAATTAGTACAGCAGAAGATACAACAGGCGGATACAGCGATGCTGATTTCCTTCGAATTAATCAATTTTACAT
GGAAACATCACAAAATGCAGCTATTTATCAAGCTTTATCCTTAGCTGGAAAACCAGTTACATTAGATTATAAAGGCGTAT
ATGTTTTAGACGTAAACAACGAATCTACTTTTAAAGGAACGTTACACTTAGCAGATACTGTAACAGGTGTAAATGGTAAA
CAGTTTACTAGTTCAGCAGAACTTATTGACTATGTTTCTCACCTAAAACTAGGGGATGAAGTTACGGTTCAGTTTACGAG
TGATAATAAGCCTAAAAAAGGAGTTGGCCGTATTATCAAACTGAAAAATGGGAAAAATGGGATTGGCATTGCCTTGACTG
ATCATACAAGTGTCAATTCAGAAGACACAGTGATCTTTAGTACTAAAGGAGTAGGAGGACCTAGTGCTGGTCTAATGTTT
ACTCTTGATATATATGATCAAATAACTAAAGAAGATTTACGCAAGGGCCGTACAATTGCAGGTACAGGAACTATTGGCAA
GGATGGCGAAGTAGGAGATATTGGTGGTGCAGGTCTTAAAGTAGTTGCAGCAGCTGAAGCTGGTGCAGATATATTTTTTG
TTCCGAATAATCCTGTTGATAAGGAAATTAAAAAAGTTAATCCAAATGCTATAAGTAATTACGAAGAAGCCAAACGGGCA
GCCAAACGACTAAAGACCAAAATGAAGATTGTTCCTGTTACGACTGTTCAAGAGGCACTGGTTTATCTTCGCAAATAA

Domains

Predicted by InterproScan.

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (233-309)

• PDZ domain (PDZ_2) (129-192)

3D structure

• AlphaFold DB: A0A4U9I5V9

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	69.275	100	0.693