Detailed information NTG1036922

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: ACB348_RS03460
• Genome accession: NZ_CP167002
• Coordinates: 644280..645317 (+)
• Length: 345 a.a.
• NCBI ID: WP_010922499.1
• Uniprot ID: A0A4U9I5V9
• Organism: Streptococcus pyogenes strain Isolate 30
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 639280..650317

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ACB348_RS03435 (ACB348_03435)	-	639544..640875 (+)	1332	WP_111704983.1	dipeptidase	-
ACB348_RS03440 (ACB348_03440)	arcC	640895..641845 (+)	951	WP_076634519.1	carbamate kinase	-
ACB348_RS03445 (ACB348_03445)	asnA	642158..643150 (+)	993	WP_023611792.1	aspartate--ammonia ligase	-
ACB348_RS03450 (ACB348_03450)	rsmD	643273..643812 (+)	540	WP_002983819.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
ACB348_RS03455 (ACB348_03455)	coaD	643802..644293 (+)	492	WP_002983821.1	pantetheine-phosphate adenylyltransferase	-
ACB348_RS03460 (ACB348_03460)	sepM	644280..645317 (+)	1038	WP_010922499.1	SepM family pheromone-processing serine protease	Regulator
ACB348_RS03465 (ACB348_03465)	-	645722..646699 (+)	978	WP_111704984.1	LacI family DNA-binding transcriptional regulator	-
ACB348_RS03470 (ACB348_03470)	-	647147..647767 (+)	621	WP_002992791.1	YutD family protein	-
ACB348_RS03475 (ACB348_03475)	rlmN	647771..648850 (+)	1080	WP_020905325.1	23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN	-
ACB348_RS03480 (ACB348_03480)	-	648932..649558 (-)	627	WP_111704985.1	A24 family peptidase	-
ACB348_RS03485 (ACB348_03485)	-	649786..650313 (+)	528	WP_002983837.1	Dps family protein	-

Sequence

Protein

• Length: 345 a.a.
• Molecular weight: 37541.24 Da
• Isoelectric Point: 9.6692

>NTDB_id=1036922 ACB348_RS03460 WP_010922499.1 644280..645317(+) (sepM) [Streptococcus pyogenes strain Isolate 30]
MKRLKKIKWWLVGLLALISLLLALFFPLPYYIEMPGGAYDIRTVLQVNGKEDKRKGAYQFVAVGISRASLAQLLYAWLTP
FTEISTAEDTTGGYSDADFLRINQFYMETSQNAAIYQALSLAGKPVTLDYKGVYVLDVNNESTFKGTLHLADTVTGVNGK
QFTSSAELIDYVSHLKLGDEVTVQFTSDNKPKKGVGRIIKLKNGKNGIGIALTDHTSVNSEDTVIFSTKGVGGPSAGLMF
TLDIYDQITKEDLRKGRTIAGTGTIGKDGEVGDIGGAGLKVVAAAEAGADIFFVPNNPVDKEIKKVNPNAISNYEEAKRA
AKRLKTKMKIVPVTTVQEALVYLRK

Nucleotide

• Length: 1038 bp

>NTDB_id=1036922 ACB348_RS03460 WP_010922499.1 644280..645317(+) (sepM) [Streptococcus pyogenes strain Isolate 30]
ATGAAAAGACTTAAAAAAATCAAATGGTGGTTAGTGGGTCTGCTAGCTTTAATCTCTTTGTTGCTAGCGTTATTTTTTCC
GCTACCTTATTATATTGAAATGCCTGGAGGCGCTTACGATATTCGGACTGTCTTACAAGTCAATGGTAAAGAAGACAAAC
GAAAAGGAGCTTACCAGTTTGTTGCAGTGGGCATTAGTCGTGCCAGCCTCGCTCAGCTATTATATGCTTGGCTGACACCG
TTTACTGAAATTAGTACAGCAGAAGATACAACAGGCGGATACAGCGATGCTGATTTCCTTCGAATTAATCAATTTTACAT
GGAAACATCACAAAATGCAGCTATTTATCAAGCTTTATCCTTAGCTGGAAAACCAGTTACATTAGATTATAAAGGCGTAT
ATGTTTTAGACGTAAACAACGAATCTACTTTTAAAGGAACGTTACACTTAGCAGATACTGTAACAGGTGTAAATGGTAAA
CAGTTTACTAGTTCAGCAGAACTTATTGACTATGTTTCTCACCTAAAACTAGGGGATGAAGTTACGGTTCAGTTTACGAG
TGATAATAAGCCTAAAAAAGGAGTTGGCCGTATTATCAAACTGAAAAATGGGAAAAATGGGATTGGCATTGCCTTGACTG
ATCATACAAGTGTCAATTCAGAAGACACAGTGATCTTTAGTACTAAAGGAGTAGGAGGACCTAGTGCTGGTCTAATGTTT
ACTCTTGATATATATGATCAAATAACTAAAGAAGATTTACGCAAGGGCCGTACAATTGCAGGTACAGGAACTATTGGCAA
GGATGGCGAAGTAGGAGATATTGGTGGTGCAGGTCTTAAAGTAGTTGCAGCAGCTGAAGCTGGTGCAGATATATTTTTTG
TTCCGAATAATCCTGTTGATAAGGAAATTAAAAAAGTTAATCCAAATGCTATAAGTAATTACGAAGAAGCCAAACGGGCA
GCCAAACGACTAAAGACCAAAATGAAGATTGTTCCTGTTACGACTGTTCAAGAGGCACTGGTTTATCTTCGCAAATAG

Domains

Predicted by InterproScan.

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (233-309)

• PDZ domain (PDZ_2) (129-192)

3D structure

• AlphaFold DB: A0A4U9I5V9

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	69.275	100	0.693