Detailed information NTG1036777

Bioinformatically predicted

Overview

• Name: clpC
• Type: Regulator
• Locus tag: ACB350_RS08675
• Genome accession: NZ_CP166999
• Coordinates: 1714160..1716604 (-)
• Length: 814 a.a.
• NCBI ID: WP_030127370.1
• Uniprot ID: -
• Organism: Streptococcus pyogenes strain Isolate 34
• Function: degradation of ComX (predicted from homology) Competence regulation

Genomic Context

Location: 1709160..1721604

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ACB350_RS08650 (ACB350_08645)	-	1709331..1710830 (+)	1500	WP_030127368.1	C69 family dipeptidase	-
ACB350_RS08655 (ACB350_08650)	-	1711174..1711504 (+)	331	Protein_1645	NUDIX domain-containing protein	-
ACB350_RS08660 (ACB350_08655)	-	1711535..1711829 (-)	295	Protein_1646	helix-turn-helix domain-containing protein	-
ACB350_RS08665 (ACB350_08660)	groL	1712031..1713656 (-)	1626	WP_030127369.1	chaperonin GroEL	-
ACB350_RS08670 (ACB350_08665)	groES	1713692..1713982 (-)	291	WP_002991292.1	co-chaperone GroES	-
ACB350_RS08675 (ACB350_08670)	clpC	1714160..1716604 (-)	2445	WP_030127370.1	ATP-dependent Clp protease ATP-binding subunit	Regulator
ACB350_RS08680 (ACB350_08675)	-	1716604..1717065 (-)	462	WP_002982312.1	CtsR family transcriptional regulator	-
ACB350_RS08685 (ACB350_08680)	-	1717261..1717464 (-)	204	WP_002991299.1	cold-shock protein	-
ACB350_RS08695 (ACB350_08690)	ahpC	1718450..1719010 (+)	561	WP_002982304.1	alkyl hydroperoxide reductase subunit C	-
ACB350_RS08700 (ACB350_08695)	ahpF	1719031..1720563 (+)	1533	WP_030127371.1	alkyl hydroperoxide reductase subunit F	-

Sequence

Protein

• Length: 814 a.a.
• Molecular weight: 90714.45 Da
• Isoelectric Point: 6.9601

>NTDB_id=1036777 ACB350_RS08675 WP_030127370.1 1714160..1716604(-) (clpC) [Streptococcus pyogenes strain Isolate 34]
MIMYSTKMQDIFRQAQFQAARFDSHCLETWHVLLAMVAVDNSLANMILSEYDAQVAIEEYEAAAILAMGKTPKEQLSRVD
FRPQSKTLTNLLAFAQAISQITRDQEVGSEHVLFAILLNPDIMASRLLEIAGYQIKDNGNGQPRLADLRKAIERHAGYSK
EMIKAIHELRKPKKTKTQGTFSDMMKPPSTAGELSDFTRDLTEMARQGLLESVIGRDQEVSRMIQVLSRKTKNNPVLVGD
AGVGKTALAYGLAQRIANGAIPYELKEMRVLELDMMSVVAGTRFRGDFEERMNQIIDDIEADGQIILFVDELHTIMGSGS
GIDSTLDAANILKPALSRGTLHMVGATTQEEYQKHIEKDAALSRRFAKILIEEPNTEDAYQILMGLKLSYETYHNVSISN
EAVKTAVKMAHRYLTSKNLPDSAIDLLDEASAAVQNMVKKSAPETLTPIDQALINGDMKKVSRLLAKEAKGQMRKPTPVT
EDDILATLSKLSGIPLEKLTQADSKKYLNLEKELHKRVIGQDAAVTAISRAIRRNQSGIRTGKRPIGSFMFLGPTGVGKT
ELAKALAEVLFDDEAALIRFDMSEYMEKFAASRLNGAPPGYVGYDEGGELTQKVRNKPYSVLLFDEVEKAHPDIFNVLLQ
VLDDGILTDSRGRKVDFSNTIIIMTSNLGATALRDDKTVGFGVKGIHQDHQAMEKRILEELRKTYRPEFINRIDEKVVFH
SLTQDNMRDVVKIMVQPLITTLVEKGITLKIQPLALKHLSEVGYDEHMGARPLRRTLQTEIEDKLSELILSRELTSGHTL
KIGLSHSKLTFHIA

Nucleotide

• Length: 2445 bp

>NTDB_id=1036777 ACB350_RS08675 WP_030127370.1 1714160..1716604(-) (clpC) [Streptococcus pyogenes strain Isolate 34]
ATGATTATGTATTCAACGAAGATGCAAGACATTTTTAGACAGGCGCAGTTCCAAGCTGCTCGCTTTGATAGCCATTGCCT
GGAAACTTGGCATGTTTTGTTAGCTATGGTAGCTGTAGACAATTCTTTAGCAAATATGATTTTAAGTGAATATGATGCCC
AAGTCGCCATAGAAGAATATGAAGCTGCAGCTATTTTAGCCATGGGCAAAACCCCTAAGGAACAGTTGTCTCGTGTAGAC
TTCAGACCTCAATCTAAAACCTTGACTAACTTGTTAGCTTTTGCGCAGGCTATTAGCCAAATCACTAGGGATCAAGAAGT
CGGCTCTGAGCATGTCTTATTTGCTATTTTATTGAATCCAGATATTATGGCGAGTCGTTTGTTAGAAATAGCTGGCTATC
AGATAAAAGATAACGGCAATGGGCAGCCGCGATTAGCTGACTTGCGAAAAGCAATAGAACGTCATGCAGGTTACAGTAAG
GAAATGATCAAGGCTATTCACGAACTACGTAAGCCTAAAAAAACGAAAACACAAGGGACCTTTTCAGATATGATGAAGCC
ACCAAGTACAGCTGGTGAGTTGAGTGATTTCACAAGAGATTTGACTGAAATGGCAAGACAAGGTTTGTTAGAATCGGTGA
TTGGACGTGACCAAGAAGTATCTCGTATGATTCAGGTACTAAGTCGTAAAACGAAAAACAATCCTGTCTTGGTAGGTGAT
GCAGGTGTTGGTAAAACTGCGCTTGCTTATGGCCTTGCTCAACGGATTGCAAATGGCGCTATTCCTTATGAACTTAAGGA
GATGCGTGTCCTAGAATTAGACATGATGAGTGTGGTAGCAGGAACCCGTTTTCGTGGGGATTTTGAAGAGCGCATGAATC
AAATCATTGATGATATTGAAGCTGATGGTCAGATTATTCTTTTTGTTGATGAACTACATACTATTATGGGTTCTGGCAGT
GGTATTGACAGTACACTTGATGCGGCTAACATTTTAAAACCAGCATTATCGCGCGGCACTCTTCATATGGTTGGAGCAAC
AACTCAAGAAGAATACCAAAAACATATTGAAAAAGATGCAGCTCTTTCGCGTCGTTTTGCTAAAATATTAATTGAAGAAC
CTAATACAGAAGATGCTTATCAGATTTTGATGGGCCTAAAATTATCTTATGAGACCTACCATAATGTCTCGATATCAAAT
GAGGCAGTTAAAACAGCTGTAAAAATGGCACACCGTTATTTAACCAGTAAAAATCTCCCTGATTCAGCTATCGATTTATT
AGATGAAGCTAGTGCTGCTGTGCAAAACATGGTGAAAAAATCAGCACCTGAGACTTTAACACCAATAGACCAAGCTCTTA
TCAATGGTGATATGAAAAAAGTATCTCGCCTCTTAGCTAAAGAAGCAAAAGGTCAGATGAGAAAACCAACACCAGTCACA
GAAGATGATATTTTGGCAACCTTGAGTAAGTTATCGGGAATTCCACTTGAAAAACTGACGCAAGCTGATAGCAAAAAATA
CCTCAATTTAGAAAAAGAACTGCATAAGCGTGTGATTGGTCAGGATGCTGCTGTTACGGCTATTTCAAGAGCCATTCGTC
GCAATCAGTCAGGTATTCGAACAGGAAAACGTCCTATTGGATCATTTATGTTTCTTGGCCCAACAGGAGTAGGTAAGACA
GAACTAGCAAAGGCCCTTGCAGAAGTTCTCTTTGATGATGAAGCAGCGCTTATTCGTTTTGATATGTCTGAGTACATGGA
AAAATTCGCAGCGTCTAGGCTTAATGGAGCACCTCCTGGTTATGTCGGCTATGATGAAGGAGGTGAACTGACACAGAAAG
TTAGAAATAAACCTTATTCAGTCTTGCTTTTTGATGAAGTGGAAAAAGCACATCCTGATATTTTTAACGTTCTCCTTCAA
GTATTAGATGATGGTATATTGACTGATAGTCGTGGGCGTAAGGTCGATTTTTCAAATACTATTATTATCATGACCAGCAA
TCTTGGCGCAACAGCCCTGCGTGATGATAAAACGGTCGGTTTTGGGGTCAAAGGCATTCACCAAGACCATCAAGCTATGG
AGAAACGTATCTTAGAAGAATTAAGAAAAACTTACCGCCCAGAATTTATCAATCGTATTGATGAAAAAGTGGTCTTTCAT
AGTCTGACCCAAGATAACATGCGCGATGTGGTTAAAATCATGGTACAGCCCCTGATTACTACATTGGTAGAAAAAGGTAT
TACCCTTAAAATTCAGCCTTTGGCCTTGAAACATTTGTCCGAGGTCGGCTATGATGAGCATATGGGGGCAAGACCATTAC
GTCGAACGCTGCAAACTGAGATAGAAGATAAGCTATCAGAGCTTATCCTTTCTCGAGAATTGACAAGTGGGCATACGCTA
AAAATTGGATTATCACATAGCAAATTAACGTTTCACATAGCTTAA

Domains

Predicted by InterproScan.

• AAA domain (Cdc48 subfamily) (AAA_2) (544-715)

• AAA lid domain (AAA_lid_9) (376-459)

• Clp amino terminal domain, pathogenicity island component (Clp_N) (95-130)

• C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small) (722-801)

• ATPase family associated with various cellular activities (AAA) (AAA) (236-368)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
clpC	Streptococcus mutans UA159	75.031	99.877	0.749
clpC	Streptococcus thermophilus LMG 18311	71.201	100	0.714
clpC	Streptococcus thermophilus LMD-9	71.078	100	0.713
clpC	Streptococcus pneumoniae TIGR4	65.848	100	0.658
clpC	Streptococcus pneumoniae Rx1	65.725	100	0.657
clpC	Streptococcus pneumoniae D39	65.725	100	0.657
clpC	Lactococcus lactis subsp. lactis strain DGCC12653	47.733	100	0.491
clpC	Bacillus subtilis subsp. subtilis str. 168	42.77	100	0.432