Detailed information NTG1036713

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: ACB356_RS05865
• Genome accession: NZ_CP166998
• Coordinates: 1173476..1174513 (-)
• Length: 345 a.a.
• NCBI ID: WP_002989068.1
• Uniprot ID: Q1JKX2
• Organism: Streptococcus pyogenes strain Isolate 35
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 1168476..1179513

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ACB356_RS05840 (ACB356_05840)	-	1168480..1169007 (-)	528	WP_002983837.1	Dps family protein	-
ACB356_RS05845 (ACB356_05845)	-	1169235..1169861 (+)	627	WP_002989076.1	A24 family peptidase	-
ACB356_RS05850 (ACB356_05850)	rlmN	1169943..1171022 (-)	1080	WP_002989074.1	23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN	-
ACB356_RS05855 (ACB356_05855)	-	1171026..1171646 (-)	621	WP_032461520.1	YutD family protein	-
ACB356_RS05860 (ACB356_05860)	-	1172094..1173071 (-)	978	WP_002989070.1	LacI family DNA-binding transcriptional regulator	-
ACB356_RS05865 (ACB356_05865)	sepM	1173476..1174513 (-)	1038	WP_002989068.1	SepM family pheromone-processing serine protease	Regulator
ACB356_RS05870 (ACB356_05870)	coaD	1174500..1174991 (-)	492	WP_002983821.1	pantetheine-phosphate adenylyltransferase	-
ACB356_RS05875 (ACB356_05875)	rsmD	1174981..1175520 (-)	540	WP_002983819.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
ACB356_RS05880 (ACB356_05880)	asnA	1175643..1176635 (-)	993	WP_002983817.1	aspartate--ammonia ligase	-
ACB356_RS05885 (ACB356_05885)	arcC	1176949..1177899 (-)	951	WP_002989065.1	carbamate kinase	-
ACB356_RS05890 (ACB356_05890)	-	1177919..1179250 (-)	1332	WP_002989063.1	dipeptidase	-

Sequence

Protein

• Length: 345 a.a.
• Molecular weight: 37527.17 Da
• Isoelectric Point: 9.5788

>NTDB_id=1036713 ACB356_RS05865 WP_002989068.1 1173476..1174513(-) (sepM) [Streptococcus pyogenes strain Isolate 35]
MKRLNKIKWWLVGLLALISLLLALFFPLPYYIEMPGGAYDIRTVLQVNGKEDKRKGAYQFVAVGISRASLAQLLYAWLTP
FTEISTAEDTTGGYSDADFLRINQFYMETSQNAAIYQALSLAGKPVTLDYKGVYVLDVNNESTFKGTLHLADTVTGVNGK
QFTSSAELIDYVSHLKLGDEVTVQFTSDNKPKKGVGRIIKLKNGKNGIGIALTDHTSVNSEDTVIFSTKGVGGPSAGLMF
TLDIYDQITKEDLRKGRTIAGTGTIGKDGEVGDIGGAGLKVVAAAEAGADIFFVPNNPVDKEIKKVNPNAISNYEEAKRA
AKRLKTKMKIVPVTTVQEALVYLRK

Nucleotide

• Length: 1038 bp

>NTDB_id=1036713 ACB356_RS05865 WP_002989068.1 1173476..1174513(-) (sepM) [Streptococcus pyogenes strain Isolate 35]
ATGAAAAGACTTAACAAAATCAAATGGTGGTTAGTGGGTCTGCTAGCTTTAATCTCTTTGTTGCTAGCGTTATTTTTTCC
GCTACCTTATTATATTGAAATGCCTGGAGGCGCTTACGATATTCGGACTGTCTTACAAGTCAATGGCAAAGAAGACAAAC
GAAAAGGAGCTTACCAGTTTGTTGCAGTGGGCATTAGTCGTGCCAGCCTCGCTCAGCTATTATATGCTTGGCTGACACCG
TTTACTGAAATTAGTACAGCAGAAGATACAACAGGCGGATACAGCGATGCTGATTTCCTTCGAATTAATCAATTTTACAT
GGAAACATCACAAAATGCAGCTATTTATCAAGCTTTATCCTTAGCTGGAAAACCAGTTACATTAGATTATAAAGGCGTAT
ATGTTTTAGACGTAAACAACGAATCTACTTTTAAAGGAACGTTACACTTAGCAGATACTGTAACAGGTGTAAATGGTAAA
CAGTTTACTAGTTCAGCAGAACTTATTGACTATGTTTCTCACCTAAAACTAGGGGATGAAGTTACGGTTCAGTTTACGAG
TGATAATAAGCCTAAAAAAGGAGTTGGCCGTATTATCAAACTGAAAAATGGGAAAAATGGGATTGGCATTGCCTTGACTG
ATCATACAAGTGTCAATTCAGAAGACACAGTGATCTTTAGTACTAAAGGAGTAGGAGGACCTAGTGCTGGTCTAATGTTT
ACTCTTGATATATATGATCAAATAACTAAAGAAGATTTACGCAAGGGCCGTACAATTGCAGGTACAGGAACTATTGGCAA
GGATGGCGAAGTAGGAGATATTGGTGGTGCAGGTCTTAAAGTAGTTGCAGCAGCTGAAGCTGGTGCAGATATATTTTTTG
TTCCGAATAATCCTGTTGATAAGGAAATTAAAAAAGTTAATCCAAATGCTATAAGTAATTACGAAGAAGCCAAACGGGCA
GCCAAACGACTAAAGACCAAAATGAAGATTGTTCCTGTTACGACTGTTCAAGAGGCACTGGTTTATCTTCGCAAATAG

Domains

Predicted by InterproScan.

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (233-309)

• PDZ domain (PDZ_2) (129-192)

3D structure

• AlphaFold DB: Q1JKX2

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	68.986	100	0.69