Detailed information NTG1035822

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: ACA109_RS03150
• Genome accession: NZ_CP166872
• Coordinates: 598107..599150 (+)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain 24EBSta0529
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 593107..604150

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ACA109_RS03120 (ACA109_03120)	-	593664..593774 (+)	111	WP_001790257.1	hypothetical protein	-
ACA109_RS03125 (ACA109_03125)	-	593803..594216 (+)	414	WP_025174552.1	hypothetical protein	-
ACA109_RS03130 (ACA109_03130)	-	594405..595391 (-)	987	WP_000999715.1	aromatic acid exporter family protein	-
ACA109_RS03135 (ACA109_03135)	map	596033..596791 (+)	759	WP_000636142.1	type I methionyl aminopeptidase	-
ACA109_RS03140 (ACA109_03140)	-	597008..597394 (+)	387	WP_001110179.1	hypothetical protein	-
ACA109_RS03145 (ACA109_03145)	liaF	597409..598110 (+)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
ACA109_RS03150 (ACA109_03150)	vraS	598107..599150 (+)	1044	WP_001017131.1	sensor histidine kinase	Regulator
ACA109_RS03155 (ACA109_03155)	vraR	599140..599769 (+)	630	WP_000153526.1	two-component system response regulator VraR	Regulator
ACA109_RS03160 (ACA109_03160)	-	599882..601099 (-)	1218	WP_371257123.1	YihY/virulence factor BrkB family protein	-
ACA109_RS03165 (ACA109_03165)	-	601377..601652 (-)	276	WP_000428172.1	YtxH domain-containing protein	-
ACA109_RS03170 (ACA109_03170)	-	601659..602123 (-)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
ACA109_RS03175 (ACA109_03175)	-	602270..602470 (+)	201	WP_000180460.1	DUF1128 family protein	-
ACA109_RS03180 (ACA109_03180)	-	602473..603729 (+)	1257	WP_371257124.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=1035822 ACA109_RS03150 WP_001017131.1 598107..599150(+) (vraS) [Staphylococcus aureus strain 24EBSta0529]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=1035822 ACA109_RS03150 WP_001017131.1 598107..599150(+) (vraS) [Staphylococcus aureus strain 24EBSta0529]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAACGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTTGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTCAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1