Detailed information NTG1030345

Bioinformatically predicted

Overview

• Name: clpE
• Type: Regulator
• Locus tag: AB6M97_RS04345
• Genome accession: NZ_CP163514
• Coordinates: 911970..914234 (-)
• Length: 754 a.a.
• NCBI ID: WP_121834376.1
• Uniprot ID: A0A3L9DY85
• Organism: Streptococcus hillyeri strain S23-3001-1
• Function: repress competence development (at the early growth phase) (predicted from homology) Competence regulation

Genomic Context

Location: 906970..919234

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
AB6M97_RS04325 (AB6M97_04325)	-	908516..909919 (+)	1404	WP_369351129.1	6-phospho-beta-glucosidase	-
AB6M97_RS04330 (AB6M97_04330)	-	909999..910571 (+)	573	WP_121834373.1	DJ-1 family glyoxalase III	-
AB6M97_RS04335 (AB6M97_04335)	-	910564..911118 (+)	555	WP_121834374.1	DJ-1 family glyoxalase III	-
AB6M97_RS04340 (AB6M97_04340)	-	911131..911901 (+)	771	WP_121834375.1	MurR/RpiR family transcriptional regulator	-
AB6M97_RS04345 (AB6M97_04345)	clpE	911970..914234 (-)	2265	WP_121834376.1	ATP-dependent Clp protease ATP-binding subunit	Regulator
AB6M97_RS04350 (AB6M97_04350)	-	914576..914806 (+)	231	WP_121834377.1	DUF1797 family protein	-
AB6M97_RS04355 (AB6M97_04355)	-	915387..916067 (+)	681	WP_121834378.1	amino acid ABC transporter permease	-
AB6M97_RS04360 (AB6M97_04360)	-	916069..916803 (+)	735	WP_121834379.1	amino acid ABC transporter ATP-binding protein	-

Sequence

Protein

• Length: 754 a.a.
• Molecular weight: 83390.61 Da
• Isoelectric Point: 4.9679

>NTDB_id=1030345 AB6M97_RS04345 WP_121834376.1 911970..914234(-) (clpE) [Streptococcus hillyeri strain S23-3001-1]
MLCQNCNLNESSIHLYTNVNGQQKKVDLCQHCYQIMKSGSGEPDMFLHGGSLNPFLEDFFGDLNNFRAFNPDLPNAPKTQ
SGRFGGNGGAGNGGGNPNRPQGARQQAPQQPKGLLEEFGVNVTDIARNGDIDPVIGRDEEIVRVIEILNRRTKNNPVLIG
EPGVGKTAVVEGLAQKIVDGNVPQKLQGKQVIRLDVVSLVQGTGIRGQFEERMQKLMEEIRSRKDVILFIDEIHEIVGAG
SAGDGNMDAGNILKPALARGELQMVGATTLNEYRIIEKDAALERRMQPVKVDEPSVEETITILRGIQPKYQDYHHVKYTD
DAIVAAAELSNRYIQDRFLPDKAIDLLDEAGSKMNLTLNFVDPKDIDKRLVEAENLKAQATRDEDFEKAAYFRDQIAKYK
EMQQQTITDQDMPVITEKHIEAIIEQKTNIPVGDLKEKEQSQLINLASDLKSHVIGQDDAVDKIAKAIRRNRVGLGSPNR
PIGSFLFVGPTGVGKTELSKQLAIELFGSADSMIRFDMSEYMEKHAVAKLVGAPPGYVGYEEAGQLTEKVRRNPYSLILL
DEVEKAHPDVMHMFLQVLDDGRLTDGQGRTVSFKDTIIIMTSNAGTGKVEASVGFGAAREGRTNSVLGQLGDFFSPEFMN
RFDGIIEFSALSKENLLSIVDLMLDSVNERLSHNGLSLSVTDKVKEKLVDLGYDPKMGARPLRRTIQDHIEDAITDFYLE
NPTEKEFKAVMSSNGNIIIKSGKKVEVAETVIED

Nucleotide

• Length: 2265 bp

>NTDB_id=1030345 AB6M97_RS04345 WP_121834376.1 911970..914234(-) (clpE) [Streptococcus hillyeri strain S23-3001-1]
ATGCTATGTCAAAATTGTAACCTTAATGAATCTAGCATTCATCTCTATACTAATGTTAATGGCCAACAAAAAAAGGTTGA
CCTCTGCCAACATTGTTATCAAATCATGAAATCTGGTTCTGGGGAACCTGATATGTTCCTACACGGAGGTTCACTAAATC
CCTTCTTAGAAGATTTCTTTGGTGACCTCAATAACTTCCGCGCCTTCAATCCTGATTTGCCAAATGCGCCAAAAACTCAA
TCTGGACGTTTTGGTGGCAATGGCGGAGCAGGTAATGGCGGTGGGAATCCTAATCGCCCTCAAGGTGCACGCCAACAAGC
GCCTCAGCAGCCAAAAGGCCTTCTTGAGGAATTCGGTGTGAATGTGACTGACATTGCACGAAACGGAGACATTGATCCTG
TTATTGGACGTGACGAAGAAATTGTCCGTGTGATCGAAATTCTAAACCGTCGTACCAAAAACAACCCTGTCCTTATCGGT
GAGCCAGGGGTCGGTAAAACAGCCGTTGTCGAAGGCCTTGCTCAGAAAATCGTGGACGGTAACGTGCCACAAAAACTTCA
AGGTAAACAAGTGATTCGCCTTGATGTCGTTAGCCTCGTTCAAGGGACTGGTATCCGTGGGCAATTTGAAGAACGCATGC
AAAAATTGATGGAGGAAATCCGCAGTCGTAAGGATGTCATTCTCTTCATCGATGAAATTCATGAAATCGTTGGTGCTGGT
TCTGCTGGTGATGGCAATATGGACGCTGGCAACATCTTGAAACCAGCCCTTGCTCGCGGGGAATTGCAAATGGTTGGTGC
TACTACACTCAACGAGTACCGTATCATCGAAAAAGATGCTGCACTTGAACGCCGTATGCAACCTGTCAAAGTTGACGAAC
CTTCTGTTGAAGAAACCATCACCATCTTGCGTGGTATCCAACCAAAATATCAGGACTACCATCACGTCAAATATACCGAT
GATGCTATCGTTGCTGCAGCTGAATTATCAAACCGCTACATTCAAGACCGCTTCTTGCCTGATAAGGCAATTGACCTCTT
GGACGAAGCTGGTTCAAAAATGAATTTAACCCTCAACTTTGTTGATCCTAAAGATATTGACAAACGTCTTGTGGAAGCTG
AAAACCTCAAAGCTCAAGCAACACGCGATGAAGACTTTGAAAAAGCAGCCTACTTCCGTGATCAAATTGCTAAATACAAA
GAAATGCAGCAGCAAACCATTACCGACCAAGATATGCCAGTCATCACTGAAAAACACATTGAGGCTATTATTGAGCAAAA
AACCAATATCCCTGTCGGTGATTTGAAGGAGAAAGAACAAAGCCAGCTCATCAATCTTGCTAGTGATTTGAAATCACACG
TTATCGGTCAAGACGATGCCGTTGATAAGATTGCCAAAGCCATTCGCCGTAACCGTGTTGGTCTCGGTTCACCAAACCGT
CCAATCGGTAGCTTCCTCTTTGTCGGACCAACTGGGGTTGGTAAAACAGAACTTTCTAAGCAATTAGCAATTGAGCTCTT
TGGCTCTGCAGACAGCATGATTCGCTTTGATATGTCTGAATACATGGAAAAACATGCCGTTGCGAAACTCGTAGGAGCCC
CTCCAGGATATGTCGGTTATGAAGAAGCTGGACAACTCACTGAAAAAGTGCGCCGTAACCCTTATTCACTTATCCTTCTT
GACGAAGTTGAAAAAGCTCACCCAGATGTCATGCACATGTTCTTACAAGTCCTTGATGATGGTCGCCTCACAGATGGTCA
AGGACGTACGGTGAGCTTCAAGGATACCATTATCATCATGACCTCAAATGCTGGTACTGGTAAAGTCGAAGCTTCTGTTG
GCTTTGGTGCTGCTCGAGAAGGCCGTACCAATTCCGTTCTTGGACAACTTGGAGACTTCTTCAGCCCAGAATTCATGAAT
CGCTTTGACGGTATCATCGAATTCTCTGCCCTCAGCAAAGAAAACCTCCTTTCTATCGTTGACCTCATGCTTGATAGTGT
CAATGAACGCCTCAGCCACAACGGTCTCAGCCTTTCTGTAACAGATAAGGTCAAAGAAAAACTGGTTGACCTTGGCTACG
ATCCTAAGATGGGGGCACGTCCGCTGCGTCGCACCATTCAAGATCACATCGAAGATGCCATCACAGACTTCTATCTCGAA
AACCCAACTGAAAAAGAATTCAAAGCTGTAATGAGTTCAAATGGTAATATTATCATTAAATCTGGTAAAAAAGTTGAAGT
CGCTGAAACAGTGATTGAAGACTAA

Domains

Predicted by InterproScan.

• ATPase family associated with various cellular activities (AAA) (AAA) (157-270)

• AAA lid domain (AAA_lid_9) (295-393)

• C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small) (651-725)

• AAA domain (Cdc48 subfamily) (AAA_2) (480-643)

3D structure

• AlphaFold DB: A0A3L9DY85

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
clpE	Streptococcus mutans UA159	83.399	100	0.84
clpE	Streptococcus pneumoniae Rx1	81.423	100	0.82
clpE	Streptococcus pneumoniae D39	81.423	100	0.82
clpE	Streptococcus pneumoniae R6	81.423	100	0.82
clpE	Streptococcus pneumoniae TIGR4	81.423	100	0.82
clpC	Lactococcus lactis subsp. cremoris KW2	76.409	100	0.773
clpC	Bacillus subtilis subsp. subtilis str. 168	52.08	86.074	0.448
clpC	Lactococcus lactis subsp. lactis strain DGCC12653	47.193	87.401	0.412
clpC	Streptococcus pneumoniae TIGR4	47.36	82.891	0.393
clpC	Streptococcus pneumoniae Rx1	47.36	82.891	0.393
clpC	Streptococcus pneumoniae D39	47.36	82.891	0.393
clpC	Streptococcus thermophilus LMD-9	47.04	82.891	0.39
clpC	Streptococcus thermophilus LMG 18311	46.72	82.891	0.387
clpC	Streptococcus mutans UA159	46.486	83.024	0.386