Detailed information NTG1030278

Bioinformatically predicted

Overview

• Name: clpC
• Type: Regulator
• Locus tag: AB6M99_RS01160
• Genome accession: NZ_CP163513
• Coordinates: 227013..229457 (+)
• Length: 814 a.a.
• NCBI ID: WP_121835005.1
• Uniprot ID: A0A3L9DVP4
• Organism: Streptococcus hillyeri strain S23-3001-2
• Function: degradation of ComX (predicted from homology) Competence regulation

Genomic Context

Location: 222013..234457

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
AB6M99_RS01145 (AB6M99_01145)	-	224796..224954 (+)	159	WP_121835002.1	LPXTG cell wall anchor domain-containing protein	-
AB6M99_RS01150 (AB6M99_01150)	-	225242..225607 (+)	366	WP_121835003.1	DUF1033 family protein	-
AB6M99_RS01155 (AB6M99_01155)	-	226555..227010 (+)	456	WP_121835004.1	CtsR family transcriptional regulator	-
AB6M99_RS01160 (AB6M99_01160)	clpC	227013..229457 (+)	2445	WP_121835005.1	ATP-dependent Clp protease ATP-binding subunit	Regulator
AB6M99_RS01165 (AB6M99_01165)	-	229745..230893 (+)	1149	WP_121835006.1	cobalamin-independent methionine synthase II family protein	-
AB6M99_RS01170 (AB6M99_01170)	-	231344..231955 (-)	612	WP_121835007.1	DUF6287 domain-containing protein	-
AB6M99_RS01175 (AB6M99_01175)	-	232346..232912 (+)	567	WP_121835008.1	TetR/AcrR family transcriptional regulator	-
AB6M99_RS01180 (AB6M99_01180)	dusB	233193..234170 (-)	978	WP_369350980.1	tRNA dihydrouridine synthase DusB	-

Sequence

Protein

• Length: 814 a.a.
• Molecular weight: 90111.69 Da
• Isoelectric Point: 5.8934

>NTDB_id=1030278 AB6M99_RS01160 WP_121835005.1 227013..229457(+) (clpC) [Streptococcus hillyeri strain S23-3001-2]
MVKYSLKMQEVFRLGQEQAARYESLYLETWHLLLGMVALHDSVAGLSFSEYEDEFPLEEYEAAAILAMGKAPQDDVKRTD
FLRPSSKALKEVLDYALAIAQVMANDEVGTEHVLFAMLVNADLLATRILELVGFKVKDDGNSLRLIDLRKTLERHAGITK
EDLKAIHELRKPKKAKSAGNFSDMMKPPSTAGELSDFTRDLTAMAEQGLLDPVIGRDKEVTRMIQVLSRKTKNNPVLVGD
AGVGKTALAYGLAQRIATGEIPYELQDMRVLELDMMSVVAGTRFRGDFEERMNQIIEDIETDGKIILFIDELHTIMGTGS
GVDGTLDAANILKPALSRGTLHMVGATTQAEYQKHLEKDAALSRRFAKIIIEEPSQADAIAILKGLRPSYEAFHNVSISD
EAIATAVKAAHRYLTTKQLPDSAIDLLDEASATVQVMTKKEVQETLSPVDQALLAGDLKRVSQLLKVSQKETLRPAIPVT
EDHILTTLSRLSGIPVEKLSQKDSQKYLNLETELHKRVVGQDAAVSAISRAIRRNQSGIRTGKRPIGSFMFLGPTGVGKT
ELAKALAEVLFDDESALIRFDMSEYMEKFAASRLNGAPPGYVGYDEGGELTEKVRNKPYSVLLFDEVEKAHPDIFNVLLQ
VLDDGVLTDSRGRKVDFSNTIIIMTSNLGATALRDDKTVGFGAQAISHDHKAMEKRILEELKKAYRPEFINRIDEKVVFH
SLEEVHMREIVTIMVQPLVKALADKGVTLKFQPAALKHLAQDGYDIEMGARPLRRTIQTEVEDKLSELILAGELAQGQTL
KIGFSKGKLKFDMA

Nucleotide

• Length: 2445 bp

>NTDB_id=1030278 AB6M99_RS01160 WP_121835005.1 227013..229457(+) (clpC) [Streptococcus hillyeri strain S23-3001-2]
ATGGTTAAATATTCGTTAAAAATGCAGGAAGTCTTTCGCTTAGGACAAGAGCAGGCAGCCCGCTATGAAAGTCTTTACCT
AGAGACTTGGCATTTGCTTTTAGGGATGGTGGCCCTCCATGATTCTGTAGCAGGTCTTAGTTTTTCAGAGTATGAGGATG
AATTTCCTTTAGAGGAGTATGAAGCGGCAGCTATTTTAGCCATGGGAAAAGCTCCGCAGGATGATGTGAAAAGGACTGAT
TTTCTGCGTCCATCGTCTAAAGCCTTAAAAGAGGTTCTTGACTATGCGTTAGCTATTGCTCAAGTGATGGCTAATGATGA
AGTCGGAACAGAGCACGTTCTTTTTGCTATGTTAGTGAATGCTGACTTACTGGCAACGAGAATTTTAGAGTTAGTGGGCT
TCAAGGTCAAGGATGATGGGAATTCTCTTCGCTTAATTGATCTGCGCAAGACTTTGGAGCGTCATGCGGGAATCACTAAA
GAAGATTTGAAAGCCATTCATGAATTGAGAAAACCTAAAAAAGCAAAATCTGCTGGCAACTTCTCTGATATGATGAAGCC
ACCTTCAACAGCAGGGGAACTTTCTGATTTTACACGTGATTTGACGGCAATGGCAGAGCAGGGATTGTTAGATCCTGTTA
TCGGACGCGACAAAGAAGTAACACGCATGATTCAGGTATTGAGCCGTAAGACAAAAAATAATCCTGTCCTAGTTGGGGAT
GCCGGTGTCGGAAAAACAGCTCTAGCTTACGGCCTTGCCCAGCGTATTGCTACTGGAGAAATCCCATATGAGCTCCAAGA
CATGAGAGTCTTAGAACTTGATATGATGTCTGTGGTTGCAGGAACACGTTTTCGAGGTGACTTTGAAGAGCGAATGAATC
AAATCATCGAAGACATCGAAACAGATGGGAAAATCATTCTCTTTATTGATGAACTTCATACTATTATGGGGACTGGTAGC
GGTGTTGATGGGACGCTTGATGCAGCCAATATCTTGAAACCTGCCCTTTCACGTGGAACCCTTCACATGGTTGGAGCTAC
CACACAGGCTGAGTACCAAAAACATCTTGAAAAAGATGCCGCTCTCTCTCGTCGATTTGCAAAAATTATCATTGAAGAGC
CAAGCCAAGCTGACGCTATTGCCATTTTAAAAGGACTTAGACCAAGTTACGAGGCTTTTCACAATGTTTCTATCTCAGAT
GAAGCGATTGCGACGGCTGTCAAAGCTGCGCATCGTTACTTAACAACGAAACAGTTACCAGATTCGGCTATTGATTTGCT
TGATGAGGCTAGTGCTACTGTTCAGGTCATGACTAAAAAAGAAGTCCAAGAGACTCTTAGCCCAGTTGACCAAGCTCTGC
TTGCAGGAGACTTAAAACGTGTTAGCCAGTTATTAAAAGTCTCACAAAAAGAGACCCTTCGTCCAGCAATCCCTGTGACC
GAAGACCATATTTTAACAACTCTAAGTCGCCTATCAGGGATTCCTGTGGAAAAATTAAGTCAGAAAGACAGCCAGAAATA
CTTGAACCTAGAGACGGAGTTACACAAACGTGTTGTTGGTCAAGATGCCGCTGTTTCAGCTATTAGTCGTGCCATTCGTC
GCAATCAATCAGGCATTCGTACAGGGAAACGACCAATTGGTTCCTTCATGTTCCTAGGCCCAACGGGTGTTGGTAAGACG
GAGTTGGCAAAAGCTTTAGCAGAAGTGCTCTTTGATGATGAATCAGCTCTTATTCGCTTTGACATGTCTGAGTACATGGA
AAAATTTGCGGCAAGTCGTCTTAACGGTGCCCCTCCAGGTTATGTTGGTTACGATGAGGGTGGCGAATTGACTGAGAAAG
TTCGTAATAAACCTTATTCAGTTTTACTCTTTGATGAGGTTGAAAAAGCCCATCCAGACATTTTCAATGTGCTGTTACAG
GTTCTCGATGACGGTGTTCTGACAGATAGTCGTGGACGTAAAGTTGACTTTTCAAATACCATTATCATCATGACCTCAAA
TCTTGGGGCAACCGCTCTCCGTGATGATAAGACCGTTGGATTTGGAGCGCAAGCCATTTCCCACGACCATAAGGCTATGG
AGAAACGTATCCTGGAGGAATTGAAAAAGGCTTACCGCCCAGAGTTTATCAACCGTATAGATGAAAAAGTGGTCTTCCAC
AGTCTTGAAGAGGTGCATATGCGTGAGATTGTGACGATCATGGTTCAACCTTTGGTGAAAGCTTTGGCAGACAAGGGAGT
GACCTTGAAGTTCCAACCAGCAGCTCTGAAACATCTGGCCCAAGATGGCTATGATATTGAAATGGGAGCTCGCCCACTGC
GTCGCACCATCCAAACAGAAGTTGAGGATAAACTATCTGAACTCATCTTAGCTGGTGAGCTAGCCCAAGGACAAACTCTA
AAAATCGGTTTCTCTAAAGGAAAATTAAAATTTGATATGGCTTGA

Domains

Predicted by InterproScan.

• AAA domain (Cdc48 subfamily) (AAA_2) (544-715)

• C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small) (722-802)

• AAA lid domain (AAA_lid_9) (375-450)

• Clp amino terminal domain, pathogenicity island component (Clp_N) (96-137)

• ATPase family associated with various cellular activities (AAA) (AAA) (236-370)

3D structure

• AlphaFold DB: A0A3L9DVP4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
clpC	Streptococcus thermophilus LMG 18311	74.233	100	0.743
clpC	Streptococcus thermophilus LMD-9	74.233	100	0.743
clpC	Streptococcus mutans UA159	74.293	99.877	0.742
clpC	Streptococcus pneumoniae TIGR4	66.993	100	0.673
clpC	Streptococcus pneumoniae Rx1	66.504	100	0.668
clpC	Streptococcus pneumoniae D39	66.504	100	0.668
clpC	Lactococcus lactis subsp. lactis strain DGCC12653	48.865	100	0.502
clpC	Bacillus subtilis subsp. subtilis str. 168	45.444	100	0.466
clpE	Streptococcus mutans UA159	47.717	78.01	0.372