Detailed information NTG1026192

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: AB3433_RS00870
• Genome accession: NZ_CP162469
• Coordinates: 153559..154602 (+)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain TUM20820
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 148559..159602

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
AB3433_RS00840 (AB3433_00840)	-	148867..148977 (+)	111	WP_001790257.1	hypothetical protein	-
AB3433_RS00845 (AB3433_00845)	-	149006..149419 (+)	414	WP_001837236.1	hypothetical protein	-
AB3433_RS00850 (AB3433_00850)	-	149968..150954 (-)	987	WP_000999713.1	aromatic acid exporter family protein	-
AB3433_RS00855 (AB3433_00855)	map	151485..152243 (+)	759	WP_000636142.1	type I methionyl aminopeptidase	-
AB3433_RS00860 (AB3433_00860)	-	152460..152846 (+)	387	WP_001110179.1	hypothetical protein	-
AB3433_RS00865 (AB3433_00865)	liaF	152861..153562 (+)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
AB3433_RS00870 (AB3433_00870)	vraS	153559..154602 (+)	1044	WP_001017131.1	sensor histidine kinase	Regulator
AB3433_RS00875 (AB3433_00875)	vraR	154592..155221 (+)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
AB3433_RS00880 (AB3433_00880)	-	155333..156544 (-)	1212	WP_000037091.1	YihY/virulence factor BrkB family protein	-
AB3433_RS00885 (AB3433_00885)	-	156822..157097 (-)	276	WP_000428172.1	YtxH domain-containing protein	-
AB3433_RS00890 (AB3433_00890)	-	157104..157568 (-)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
AB3433_RS00895 (AB3433_00895)	-	157715..157915 (+)	201	WP_000180460.1	DUF1128 family protein	-
AB3433_RS00900 (AB3433_00900)	-	157918..159174 (+)	1257	WP_001793428.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=1026192 AB3433_RS00870 WP_001017131.1 153559..154602(+) (vraS) [Staphylococcus aureus strain TUM20820]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=1026192 AB3433_RS00870 WP_001017131.1 153559..154602(+) (vraS) [Staphylococcus aureus strain TUM20820]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTATTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCATACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAATTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCTCGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTTTCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCGATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1