Detailed information NTG1025889

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: AB3434_RS01435
• Genome accession: NZ_CP162454
• Coordinates: 266949..267992 (+)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain TUM20926
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 261949..272992

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
AB3434_RS01405 (AB3434_01405)	-	262256..262367 (+)	112	Protein_266	hypothetical protein	-
AB3434_RS01410 (AB3434_01410)	-	262396..262809 (+)	414	WP_001837236.1	hypothetical protein	-
AB3434_RS01415 (AB3434_01415)	-	263358..264344 (-)	987	WP_000999713.1	aromatic acid exporter family protein	-
AB3434_RS01420 (AB3434_01420)	map	264875..265633 (+)	759	WP_000636142.1	type I methionyl aminopeptidase	-
AB3434_RS01425 (AB3434_01425)	-	265850..266236 (+)	387	WP_001110179.1	hypothetical protein	-
AB3434_RS01430 (AB3434_01430)	liaF	266251..266952 (+)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
AB3434_RS01435 (AB3434_01435)	vraS	266949..267992 (+)	1044	WP_001017131.1	sensor histidine kinase	Regulator
AB3434_RS01440 (AB3434_01440)	vraR	267982..268611 (+)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
AB3434_RS01445 (AB3434_01445)	-	268723..269934 (-)	1212	WP_000037091.1	YihY/virulence factor BrkB family protein	-
AB3434_RS01450 (AB3434_01450)	-	270212..270487 (-)	276	WP_000428172.1	YtxH domain-containing protein	-
AB3434_RS01455 (AB3434_01455)	-	270494..270958 (-)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
AB3434_RS01460 (AB3434_01460)	-	271105..271305 (+)	201	WP_000180460.1	DUF1128 family protein	-
AB3434_RS01465 (AB3434_01465)	-	271308..272564 (+)	1257	WP_001793428.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=1025889 AB3434_RS01435 WP_001017131.1 266949..267992(+) (vraS) [Staphylococcus aureus strain TUM20926]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=1025889 AB3434_RS01435 WP_001017131.1 266949..267992(+) (vraS) [Staphylococcus aureus strain TUM20926]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTATTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCATACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAATTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCTCGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTTTCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCGATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1